Salviae Radix Extract Prevents Cisplatin-Induced Acute Renal Failure in Rabbits

Abstract

The present study was carried out to determine if salviae radix extract (SRE) exerts a beneficial effect against cisplatin-induced renal failure in rabbits. Rabbits were pretreated with SRE orally for 7 days, followed by cisplatin injection (5 mg/kg i.p.). Cisplatin injection caused a reduction in GFR, which was accompanied by an increase in serum creatinine levels. The fractional Na⁺ excretion was increased by cisplatin injection. PAH uptake by renal cortical slices was inhibited by the administration of cisplatin. Such changes were prevented by SRE pretreatment. Cisplatin injection increased lipid peroxidation, which was prevented by SRE pretreatment. The protective effect of SRE was supported by morphological studies. Cisplatin injection reduced renal blood flow that was not affected by SRE pretreatment. Cisplatin treatment in vitro in renal cortical slices increased LDH release and lipid peroxidation, which were prevented by 0.05% SRE. These results indicate that lipid peroxidation plays a critical role in cisplatin-induced acute renal failure. SRE exerts a protective effect against renal cell injury induced by cisplatin, and its effect may be attributed to its antioxidant action. However, the underlying mechanism by which SRE has antioxidant action remains to be defined.

6‐Gingerol prevents cisplatin‐induced acute renal failure in rats

“…Srivastava et al [49] reported that CPT admnistration results in a significant increase in the activity of calcium-independent nitric oxide synthase (NOS) in rat kidney and liver leading to enhanced NO formation. Thus 6-gingerol might have inhibited inducible nitric oxide synthase and thus reduced the nitrosative stress in rat kidney It has been suggested that ROS may lead to tubular damage in CPT-treated rats [27,45]. Administration of 6-gingerol significantly and dosedependently ameliorated this CPT-induced nitrosative stress.…”

“…Earlier studies had shown that [5]-Gingerol exhibited dose-dependent inhibition of NO production and significant reduction of inducible NO synthase (iNOS) in LPS-stimulated J774.1 cells [32]. Thus 6-gingerol might have inhibited inducible nitric oxide synthase and thus reduced the nitrosative stress in rat kidney It has been suggested that ROS may lead to tubular damage in CPT-treated rats [27,45]. ROS can induce either sub-lethal or lethal cell injury that culminates in either necrosis or apoptosis.…”

Renoprotective Effect ofSpirulina fusiformison Cisplatin-Induced Oxidative Stress and Renal Dysfunction in Rats

“…[51,52] It has been suggested that ROS may lead to tubular damage in CPT-treated rats. [53,54] ROS can induce either sublethal or lethal cell injury, which culminates in either necrosis or apoptosis. The kidneys of CPT-treated rats showed marked histological alterations, especially in the outer cortex and medullary region of the kidneys, compared with the kidneys of the control group.…”

Butein Ameliorates Renal Concentrating Ability in Cisplatin-Induced Acute Renal Failure in Rats

“…11,29) In the previous study, various antioxidant agents showed protective effect against renal injury induced by cisplatin in rats. [30][31][32] In summary, butein, a plant polyphenol, ameliorates renal concentrating ability via up-regulation of renal AQP 2 water channel in rats with cisplatin-induced ARF.…”