6‐Gingerol prevents cisplatin‐induced acute renal failure in rats

Kuhad, Anurag; Tirkey, Naveen; Sah, Sangeeta Pilkhwal; Chopra, Kanwaljit

doi:10.1002/biof.5520260304

Cited by 57 publications

(43 citation statements)

References 53 publications

(89 reference statements)

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“…The interaction of ROS with cellular components may result in damage to biomolecules, including DNA, proteins, and lipids. Cisplatin treatment also induces a significant increase in the activity of calcium-independent nitric oxide synthase in rat kidney and liver tissues, resulting in an increase in serum NO levels as well as in tissue NO formation (40,41). Peroxynitrite, which is generated by the reaction between nitric oxide and superoxide anion, also oxidizes biomolecules.…”

Section: Discussionmentioning

confidence: 99%

Isoliquiritigenin Inhibits Tumor Growth and Protects the Kidney and Liver Against Chemotherapy-Induced Toxicity in a Mouse Xenograft Model of Colon Carcinoma

et al. 2008

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Abstract. A growing amount of attention has been focused on the investigation of the effects of chemopreventive agents on the inhibition of cancer cell growth and toxicity in combination with chemotherapeutics. The objective of this study was to determine whether isoliquiritigenin (ISL) has the potential to serve as a beneficial supplement during cisplatin chemotherapy. We found that the administration of ISL alone significantly reduced the size of the solid tumors in CT-26 cell-inoculated BALB / c mice, without any detectable induction of nephrotoxicity, hepatotoxicity, and oxidative stress, and ISL reduced the viability and DNA synthesis of CT-26 murine colon cancer cells in a dose-dependent manner. ISL did not affect the therapeutic efficacy of cisplatin. Furthermore, ISL suppressed cisplatin-induced kidney damage characterized by increases in serum creatinine and blood urea nitrogen, as well as cisplatin-induced liver damage characterized by increases in serum alanine aminotransferase and aspartate aminotransferase. The repeated oral administration of ISL prior to cisplatin treatment exerted a preventive effect on cisplatin-mediated increases in serum nitric oxide and tissue lipid peroxidation levels, and it recovered depleted GSH levels in the tissues. Therefore, supplementation with ISL may be an effective approach to counteracting the side effects of cisplatin therapy in cancer patients.

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Section: Discussionmentioning

confidence: 99%

Isoliquiritigenin Inhibits Tumor Growth and Protects the Kidney and Liver Against Chemotherapy-Induced Toxicity in a Mouse Xenograft Model of Colon Carcinoma

et al. 2008

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“…Cisplatin treatment also causes a significant increase in the activity of the calcium-independent nitric oxide synthase (NOS) in rat kidney and liver, leading to an increase in serum NO level as well as in tissue NO formation. 30,31) Peroxynitrite, generated by the reaction between nitric oxide and superoxide anion, oxidizes biomolecules such as DNA, proteins and lipids. In the present study, the oral administration of the licorice extract in combination with the cisplatin treatment prevented the increases in the serum nitric oxide and tissue lipid peroxidation levels, and significantly recovered the tissue GSH level and antioxidant enzyme activities in the cisplatin-treated mice.…”

Section: Discussionmentioning

confidence: 99%

Effects of the Licorice Extract against Tumor Growth and Cisplatin-Induced Toxicity in a Mouse Xenograft Model of Colon Cancer

Lee

Park

Lim

et al. 2007

Biological & Pharmaceutical Bulletin

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Cisplatin (cis-diamminedichloroplatinum II) is a platinum coordinated complex that is widely used as an antineoplastic agent for the treatment of many solid tumors, including cancers of the ovary, testis, lung, bladder, head and neck, cervix and endometrium.1) Despite its excellent anticancer activity, the clinical use of cisplatin is often limited by its undesirable side effects, such as severe nephrotoxicity and hepatotoxicity. 2,3) Although the precise mechanism for this cisplatin-induced toxicity is not well understood, cisplatin is taken up preferentially and accumulates in the human liver and kidney cells, 4) resulting in the enhanced production of reactive oxygen species (ROS) and the decrease in the antioxidant enzymes.5,6) Therefore, antioxidants have been administered before a cisplatin treatment to protect against nephrotoxicity. 7)Licorice is an esteemed crude drug in both the Orient and Occident that is originated from the dried roots of several Glycyrrhiza species, including Glycyrrhiza uralensis FISCHER, G. glabra LINNE and G. inflata BATALIN. 8,9) In Chinese traditional medicine, licorice remains one of the most commonly prescribed herbs and has been used in the treatment of various ailments ranging from tuberculosis to peptic ulcers.10) Licorice has also been employed as a flavoring and sweetening agent, as well as a demulcent and expectorant in Western countries.11) The chemical constituents of licorice include glycyrrhizin and its aglycone, glycyrrhetinic acid, which are originally isolated from aqueous extracts and are used in the treatment of hyperlipemia, atherosclerosis, viral diseases, allergic inflammation and hepatotoxicity.12,13) The acetone or ethanol extract of licorice has species-specific flavonoids, such as liquiritin, isoliquiritin and their corresponding aglycones, glabridin, glabrol, glabrene, hispaglabridin A and hispaglabridin B.14,15) These flavonoids exhibit antioxidative, 16) superoxide scavenging 16) and anticarcinogenic activities.17) However, in vivo antitumor activity of a licorice extract and its protective activity on cisplatin-induced toxicity have not yet been studied.In the present study to assess the antitumor activity of a licorice extract and whether it has the potential to serve as a beneficial supplement during cisplatin chemotherapy, we examined the inhibitory effect of the licorice extract alone and in combination with cisplatin on the tumor growth, and its protective effect against cisplatin-induced nephrotoxicity and hepatotoxicity in mice xenografted with mouse colon carcinoma cells. MATERIALS AND METHODSChemical Cisplatin, phenylmethylsulfonyl fluoride (PMSF), sodium nitrite, 1,1,3,3-tetramethoxypropane, reduced glutathione (GSH), 5,5Ј-dithiobis(2-nitrobenzoic acid) (DTNB), glutathione reductase, reduced nicotinamide adenine dinucleotide phosphate (NADPH), superoxide dismutase (SOD), xanthine oxidase, a-naphthylamine, sulfanilic acid, xanthine, catalase and 4-amino-3-hydrazino-5-mercapto-1,2,4-triazole (purpald ® ) were purchased from SigmaAldrich Chem...

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“…This result suggests that the preventive effects of TJ-19 on BLM-induced pulmonary fibrosis, at least in part, can be ascribed to antioxidative potential. The 3D-HPLC data indicated that TJ-19 contains anti-oxidative constituents including catechin, 6-gingerol, and glycyrrhizin, [14][15][16][17] further supporting the above suggestion. However, in addition to ROS, other inflammatory mediators and mechanisms are involved in the development of BLM-induced pulmonary fibrosis, and these may also affect the inhibitory effects of TJ-19 against BLM-induced pulmonary fibrosis.…”

Section: Discussionmentioning

confidence: 52%

The Ethical Kampo Formulation Sho-Seiryu-To (TJ-19) Prevents Bleomycin-Induced Pulmonary Fibrosis in Rats

Yang

Sun

Ding

et al. 2010

Biological & Pharmaceutical Bulletin

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6‐Gingerol prevents cisplatin‐induced acute renal failure in rats

Abstract: The present study demonstrates the renoprotective potential of 6-gingerol against cisplatin-induced oxidative stress and renal dysfunction in rats. Hence, 6-gingerol has a potential to be used as therapeutic adjuvant in cisplatin nephrotoxicity.

Cited by 57 publications

References 53 publications

Isoliquiritigenin Inhibits Tumor Growth and Protects the Kidney and Liver Against Chemotherapy-Induced Toxicity in a Mouse Xenograft Model of Colon Carcinoma

Isoliquiritigenin Inhibits Tumor Growth and Protects the Kidney and Liver Against Chemotherapy-Induced Toxicity in a Mouse Xenograft Model of Colon Carcinoma

Effects of the Licorice Extract against Tumor Growth and Cisplatin-Induced Toxicity in a Mouse Xenograft Model of Colon Cancer

The Ethical Kampo Formulation Sho-Seiryu-To (TJ-19) Prevents Bleomycin-Induced Pulmonary Fibrosis in Rats

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