Renoprotective Effect ofSpirulina fusiformison Cisplatin-Induced Oxidative Stress and Renal Dysfunction in Rats

Abstract

Cisplatin is an effective chemotherapeutic agent used in the treatment of a wide array of both pediatric and adult malignancies. Dose-dependent and cumulative nephrotoxicity is the major toxicity of this compound, sometimes requiring a reduction in dose or discontinuation of treatment. Recent evidences have implicated oxidative and nitrosative stress in cisplatin-induced nephrotoxicity. Spirulina fusiformis, blue-green algae, is claimed to be a potential antioxidant. The present study was designed to explore the renoprotective potential of Spirulina fusiformis against cisplatin-induced oxidative stress and renal dysfunction. Spirulina fusiformis (500,1000,1500 mg/kg(-1) p.o.) was administered 2 days before and until 3 days after cisplatin challenge (5 mg/kg(-1) i.p.). Renal injury was assessed by measuring serum creatinine, blood urea nitrogen, creatinine and urea clearance, and serum nitrite levels. Renal oxidative stress was determined by renal TBARS levels, reduced glutathione levels, and by enzymatic activity of superoxide dismutase and catalase. A single dose of cisplatin produced marked renal oxidative and nitrosative stress and significantly deranged renal functions. Chronic Spirulina fusiformis treatment significantly and dose-dependently restored renal functions, reduced lipid peroxidation, and enhanced reduced glutathione levels, superoxide dismutase, and catalase activities. The results of the present study clearly demonstrate the pivotal role of reactive oxygen species and their relation to renal dysfunction and point to the therapeutic potential of Spirulina fusiformis in cisplatin-induced nephrotoxicity.

Quality Standardization and Nephroprotective Effect of Garcinia pedunculata Roxb. Fruit rind

“…Despites its wide spread use in different solid tumors, its side effect on normal tissues like kidney, liver and neuronal tissues limits its use. 25 There are many strategies used to prevent its nephrotoxicity such as development of novel platinum based chemotherapeutic agent which causes less side effect on normal tissues such as carboplatin, hydration during cisplatin treatment, use of antioxidants, suppression of inflammatory process, inhibition of cell death pathways, decreased cisplatin uptake by renal cells etc. [26][27][28] The present study was designed to investigate renoprotective effect of aqueous extract of fruits of Garcinia pedunculata against cisplatin induced nephrotoxicity.…”

Role of losartan on the renal cortex damage induced by cisplatin in adult male albino rats

“…Dose-dependent and cumulative renal damage is the major toxicity of this compound, sometimes requiring a reduction in dose or discontinuation of treatment. Recent evidence suggests that reactive oxygen molecules are involved in the nephrotoxicity of the anticancer drug cisplatin [1][2][3].…”

Antidepressants as a New Approach for Protective Interventions of Cisplatin-Induced Nephrotoxicity

“…After a single dose of CP (50-100 mg/m 2 ), approximately onethird of the patients develop nephrotoxicity [3]. The CP chief doselimiting nephrotoxic side effect requires a reduction of the dose or discontinuation of treatment [4]. Inflammation, endoplasmic reticulum stress and oxidative stress contribute to CP-induced kidney toxicity.…”