Salusins promote cardiomyocyte growth but does not affect cardiac function in rats

Yu, Fang; Zhao, Jing; Yang, Jinghui; Gen, Bin; Wang, Shuheng; Feng, Xing; Tang, Chaoshu; Chang, Lin

doi:10.1016/j.regpep.2004.06.013

Cited by 49 publications

(24 citation statements)

References 10 publications

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“…Noriko SUZUKI 1) , Masayoshi SHICHIRI 1) , Takumi AKASHI 2) , Kengo SATO 3) , Maya SAKURADA 1) , Yuki HIRONO 1) , Takanobu YOSHIMOTO 1) , Takatoshi KOYAMA 3)…”

Section: Systemic Distribution Of Salusin Expression In the Ratunclassified

“…Salusin-β 's effects are mediated mainly by parasympathetic stimulation rather than direct suppression of cardiac contractility ( 2 ). Human salusins have been shown to promote cardiomyocyte hypertrophy ( 3 ) as well as the growth of vascular smooth muscle cells and fibroblasts ( 1 ), and to protect against apoptotic death of cardiomyocytes ( 4 ). However, the exact mechanisms underlying these actions by exogenous human salusin peptides are largely unknown, and salusin receptors have not yet been identified ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

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Systemic Distribution of Salusin Expression in the Rat

et al. 2007

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“…Noriko SUZUKI 1) , Masayoshi SHICHIRI 1) , Takumi AKASHI 2) , Kengo SATO 3) , Maya SAKURADA 1) , Yuki HIRONO 1) , Takanobu YOSHIMOTO 1) , Takatoshi KOYAMA 3)…”

Section: Systemic Distribution Of Salusin Expression In the Ratunclassified

Section: Introductionmentioning

confidence: 99%

Systemic Distribution of Salusin Expression in the Rat

et al. 2007

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“…A previous study reported the detection of salusin-α and salusin-β immunoreactivity in the stomach and in the intestines [17]. Salusins play important roles in the proliferation of the vascular smooth muscle fibroblast cells and are also capable of inhibiting the apoptosis of cardiomyocytes [18]. Moreover, salusin-α and salusin-β applications have been reported to decrease the infarct size in the heart tissue after ischemia [19].…”

Section: Introductionmentioning

confidence: 99%

Protective effect of salusin-α and salusin-β against ethanol-induced gastric ulcer in rats

Tanyeli

Eraslan

Polat

et al. 2017

Journal of Basic and Clinical Physiology and Pharmacology

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Background: Alcohol consumption has been found to be associated with gastric ulcers, including gastric mucosal lesions. Salusin-α and salusin-β are bioactive peptides having 28 and 20 amino acids, respectively. Salusin-α and salusin-β immunoreactivity has been detected in the stomach and in the intestines. It has been reported that the salusins regulate the cytokine levels and decrease the infarct area in the heart tissue after ischemia. In this study, we investigated the effects of the salusins in the gastric injury formed with ethanol. Methods: Thirty-two sprague Dawley male rats were randomly divided into four groups, including eight rats in each group as follows: Group 1: control; Group 2: ethanol 5 mL/kg; Group 3: ethanol 5 mL/kg + 5 nmol/kg salusin-α; Group 4: ethanol 5 mL/kg + 5 nmol/kg salusin-β. Results: The salusin-α level increased at a significant level in the ulcer group formed with ethanol (p < 0.001); the change in the salusin-β level is not significant. As for malondialdehyde (p < 0.05) and myeloperoxidase (p < 0.001), when compared with the control group, tumor necrosis factor-α (p < 0.05) levels increased in the group to which ethanol was applied and decreased significantly with the application of salusins. Levels of GSH and IL-1β did not change at a significant level. In addition, histopathologic analysis demonstrated that, in salusin-administered groups, mucosal injury and caspase-3 expressions were reduced. Conclusions: The suppression of salusin-α and salusin-β on caspase-3 expression by means of their effects on

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“…Salusins mainly affect the cardiovascular system (5)(6)(7)(8). Salusin-β is the most hypotensive peptide: its infusion rapidly and profoundly decreases blood pressure (BP) and heart rate (5).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, it is demonstrated to cause cardiac dysfunction via a cholinergic mechanism in rats (5). Yu et al (6) have reported that salusins may have important roles in myocardial growth and hypertrophy. Salusin-α and salusin-β show inverse actions on atherosclerosis due to their opposite regulatory effects on acyl-coenzyme A: cholesterol acyltransferases-1 (ACAT-1) (7).…”

Section: Introductionmentioning

confidence: 99%

Serum salusin-α levels in systemic lupus erythematosus and systemic sclerosis

Koca¹,

Özgen²,

Işık³

et al. 2014

Eur J Rheum

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Objective: Systemic lupus erythematosus (SLE) and systemic sclerosis (SSc), chronic inflammatory diseases, demonstrate an increased incidence of cardiovascular manifestations and subclinical atherosclerotic disease. Salusin-α is a novel bioactive peptide that suppresses the formation of macrophage foam cells, and its serum level is significantly lower in patients with angiographically proven coronary artery disease. The aims of the study were to assess serum salusin-α level and its potential association with the predictors of atherosclerosis in SLE and SSc. Material and Methods:The study included 20 SLE and 22 SSc patients and 23 healthy controls (HC). All of the participants were female. Tumour necrosis factor-α (TNF-α), IL-6 and salusin-α levels, homeostasis model assessment for insulin resistance (HOMA-IR) index and common carotid intima-media thickness (IMT) were determined.Results: Salusin-α levels were lower and the IMTs were higher in the SLE and SSc groups than in the HC group. The salusin-α level was correlated with neither the disease activity scores nor cytokine levels and IMT in the SLE and SSc groups, although it was correlated with triglyceride level in the SLE group (r=-0.564, p=0.012), and with HOMA-IR index in the HC group (r=0.485, p=0.019). Conclusion:The present preliminary study may support the idea that SSc leads to subclinical atherosclerosis, as in SLE. Moreover, it can be concluded that the decreased salusin-α levels in SLE and SSc may contribute to subclinical atherosclerosis. However, further studies with larger sample size are needed to demonstrate this contribution in SLE and SSc.

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Salusins promote cardiomyocyte growth but does not affect cardiac function in rats

Cited by 49 publications

References 10 publications

Systemic Distribution of Salusin Expression in the Rat

Systemic Distribution of Salusin Expression in the Rat

Protective effect of salusin-α and salusin-β against ethanol-induced gastric ulcer in rats

Serum salusin-α levels in systemic lupus erythematosus and systemic sclerosis

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