Salmonella Typhimurium U32 peptidase, YdcP, promotes bacterial survival by conferring protection against in vitro and in vivo oxidative stress

Hajra, Dipasree; Nair, Abhilash Vijay; Chowdhury, Atish Roy; Mukherjee, Soumyadeep; Chatterjee, Ritika; Chakravortty, Dipshikha

doi:10.1016/j.micpath.2022.105862

Cited by 4 publications

(3 citation statements)

References 43 publications

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“…Salmonella typhimurium (STM), one of the leading causes of self-limiting gastroenteritis and diarrhea in humans, 6 , 7 has been used as a model system in the present study. However, the proposed experimental methodology is suitable for investigating any naturally dried bacterial droplets.…”

Section: Introductionmentioning

confidence: 99%

phoP maintains the environmental persistence and virulence of pathogenic bacteria in mechanically stressed desiccated droplets

Hariharan¹,

Chowdhury²,

S³

et al. 2023

iScience

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Section: Introductionmentioning

confidence: 99%

phoP maintains the environmental persistence and virulence of pathogenic bacteria in mechanically stressed desiccated droplets

Hariharan¹,

Chowdhury²,

S³

et al. 2023

iScience

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“…A study conducted by He et al implicated that pR ST98 , a hybrid resistance–virulence plasmid of S. Typhi, is responsible for suppressing autophagy and promoting the survival of the bacteria in infected macrophages . Recent studies demonstrated that nontyphoidal Salmonella serovars widely use numerous novel virulence factors, such as outer membrane proteins (OmpA and PgtE), YdcP, and a novel putative collagenase, to interact with host macrophages. − High sequential homology for these novel virulence factors between Salmonella Typhi and Typhimurium indicated their involvement during typhoid fever. However, thorough and detailed research is required to annotate their exact functions in S. Typhi.…”

Section: Virulence Determinants Of Salmonella Pathogenesismentioning

confidence: 99%

From Eberthella typhi to Salmonella Typhi: The Fascinating Journey of the Virulence and Pathogenicity of Salmonella Typhi

et al. 2023

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Salmonella Typhi (S. Typhi), the invasive typhoidal serovar of Salmonella enterica that causes typhoid fever in humans, is a severe threat to global health. It is one of the major causes of high morbidity and mortality in developing countries. According to recent WHO estimates, approximately 11–21 million typhoid fever illnesses occur annually worldwide, accounting for 0.12–0.16 million deaths. Salmonella infection can spread to healthy individuals by the consumption of contaminated food and water. Typhoid fever in humans sometimes is accompanied by several other critical extraintestinal complications related to the central nervous system, cardiovascular system, pulmonary system, and hepatobiliary system. Salmonella Pathogenicity Island-1 and Salmonella Pathogenicity Island-2 are the two genomic segments containing genes encoding virulent factors that regulate its invasion and systemic pathogenesis. This Review aims to shed light on a comparative analysis of the virulence and pathogenesis of the typhoidal and nontyphoidal serovars of S. enterica.

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“…Phagocytes sequentially employ specific oxygen-derived antimicrobial effectors to clear off the infection. ROS can pervade through the bacterial membrane and cause damage to proteins and nucleic acids (Chanana et al, 2006;Hajra et al, 2022;van der Heijden et al, 2016). This stimulates a change in the membrane permeability so that the antimicrobial agents cannot penetrate the bacterial cell.…”

Section: S Typhi Virulence Overlaps With Amrmentioning

confidence: 99%

Defying the odds: Determinants of the antimicrobial response of Salmonella Typhi and their interplay

Chowdhury,

Mukherjee,

Chatterjee

et al. 2023

Molecular Microbiology

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Salmonella Typhi, the invasive serovar of S. enterica subspecies enterica, causes typhoid fever in healthy human hosts. The emergence of antibiotic‐resistant strains has consistently challenged the successful treatment of typhoid fever with conventional antibiotics. Antimicrobial resistance (AMR) in Salmonella is acquired either by mutations in the genomic DNA or by acquiring extrachromosomal DNA via horizontal gene transfer. In addition, Salmonella can form a subpopulation of antibiotic persistent (AP) cells that can survive at high concentrations of antibiotics. These have reduced the effectiveness of the first and second lines of antibiotics used to treat Salmonella infection. The recurrent and chronic carriage of S. Typhi in human hosts further complicates the treatment process, as a remarkable shift in the immune response from pro‐inflammatory Th1 to anti‐inflammatory Th2 is observed. Recent studies have also highlighted the overlap between AP, persistent infection (PI) and AMR. These incidents have revealed several areas of research. In this review, we have put forward a timeline for the evolution of antibiotic resistance in Salmonella and discussed the different mechanisms of the same availed by the pathogen at the genotypic and phenotypic levels. Further, we have presented a detailed discussion on Salmonella antibiotic persistence (AP), PI, the host and bacterial virulence factors that can influence PI, and how both AP and PI can lead to AMR.

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Salmonella Typhimurium U32 peptidase, YdcP, promotes bacterial survival by conferring protection against in vitro and in vivo oxidative stress

Cited by 4 publications

References 43 publications

phoP maintains the environmental persistence and virulence of pathogenic bacteria in mechanically stressed desiccated droplets

phoP maintains the environmental persistence and virulence of pathogenic bacteria in mechanically stressed desiccated droplets

From Eberthella typhi to Salmonella Typhi: The Fascinating Journey of the Virulence and Pathogenicity of Salmonella Typhi

Defying the odds: Determinants of the antimicrobial response of Salmonella Typhi and their interplay

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