SALMONELLA MENINGITIS<subtitle>Recovery from Meningitis Due to Salmonella Sp. (Type Montevideo), with Consideration of the Problem of Salmonella Meningitis</subtitle>

Salmonella Meningitis: Report of Three Cases in Adults and Literature Review

“…In a review of data from the New York Salmonella Center from 1939-1955 by Saphra and Winter [9], only 74 of 9,518 isolates were from the CSF and several extensive reviews of bacterial meningitis reported no cases of Salmonella infection [10,11]. Almost all reported cases have occurred in children, especially infants [1,6,12,13]. In two series of patients with typhoid fever, Osler [14] reported 11 of 2,000 patients with meningitis and Osuntokun [15] noted confusional states in 57% of 959 cases, although meningitis occurred in only 0.2% of cases.…”

“…19 patients were treated with sulfadiazine, of whom 52% recovered, while of those untreated only 6% recovered. Beene et al's review in 1951 [12] reported a 83% mortality for patients treated with chloramphenicol and tetracycline. In the 1960's and 1970's mortality declined to 59-62% in developing countries [1,15] and 30-37% in America and Europe [22,27], as more effective diagnostic and therapeutic agents became available.…”

Salmonella Meningitis in Infancy

“…Only 10 cases were found in the English literature f which were not included in the last comprehensive survey, in 1951. 2 The six cases that were found at this hospital occurred over a 10-year period, during which time approximately 330 cases of purulent meningitis were diagnosed bacteriologically. This makes the incidence of Salmonella menin¬ gitis here 1 to every 55 cases of meningitis.…”

“…However, it was pointed out that the sulfonamides had favorably affected the course of the illness in that there were 10 survivals in 19 cases that had received the drug. In the group cited by Beene,2 in 1951, the majority of which had occurred subsequent to the advent of antibiotics, there was an 82.7% mortality. However, the most recent cases seemed to show an increase in the survival rate with the use of broad antibiotic coverage.…”

Salmonella meningitis following treatment of enteritis with neomycin

“…It is now recognized that meningitis is a rare complication of infection with salmonella organisms and occurs almost exclusively in infants (Beene, Hansen and Fulton, 1951;Saphra and Winter, 1957). We report a case of salmonella meningitis in an adult.…”