Salmonella meningitis following treatment of enteritis with neomycin

Hardy, C. C.; Bansal, Ankit; Lowes, J. A.; George, C. F.

doi:10.1136/pgmj.60.702.284

Cited by 12 publications

(9 citation statements)

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“…Our review of the English language medical literature reveals a number of case series and case reports of salmonella meningitis, totaling approximately 40 adult, probably immunocompetent patients, many of whom had risk factors for developing non-enteric salmonella infection (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). In 1979, Kauffmann and St. Hilaire reviewed the existing literature in their case report of a man who developed salmonella meningitis after steroid treatment for a lumbar spine fracture complicated by paraplegia.…”

Section: Discussionmentioning

confidence: 99%

“…Almost half of all patients (48%) with bacterial meningitis present within 24 h of onset of symptoms (4). Salmonella has been recognized as the etiology of meningitis only rarely, and almost exclusively in neonates and young infants (Ͻ 4 months old) (5). In adults, salmonella meningitis has almost exclusively been reported in patients with co-morbid diseases, including human immunodeficiency virus (HIV) (6,7).…”

Section: Introductionmentioning

confidence: 99%

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Salmonella Meningitis in an Immunocompetent Adult

Carr

Weisbein

Gaieski

2011

The Journal of Emergency Medicine

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Salmonella Meningitis in an Immunocompetent Adult

Carr

Weisbein

Gaieski

2011

The Journal of Emergency Medicine

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“…26 The documented relapse rate of NTS meningitis is up to 60%. 27 The rate of relapse declined, however, with increasing length of antibiotic therapy. Our five patients who experienced relapse supposedly received appropriate treatment with ceftriaxone for 3 to 4 weeks, but meningitis relapsed 5 to 14 days after discontinuing treatment.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics, Acute Complications, and Neurologic Outcomes of Salmonella Meningitis in Saudi Infants and Children

Alsubaie

Alrabiaah

2019

J Pediatr Infect Dis

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Objective This study aimed to clarify the clinical presentations, acute complications, and long-term sequelae of Salmonella meningitis in Saudi infants and children. Methods This retrospective study, conducted from 1999 to 2016, evaluated the neurological complications and long-term outcomes of children 14 years of age and younger diagnosed with Salmonella meningitis at King Khalid University Hospital. All affected children had 3 years of follow-up to assess neurologic complications and mortality. Results Invasive Salmonella infection occurred in 141 patients. Of those, 14 (10%) had meningitis. The median age of onset of infection was 4.7 months. The most frequent symptoms at presentation included fever (100%), seizures (71%), diarrhea, and vomiting (43%). Nontyphoidal Salmonella species were isolated in all (but one) cerebrospinal fluid samples. Relapse occurred in four patients owing to inadequate antibiotic duration, although the organisms were susceptible to ceftriaxone. The majority of patients (86%) developed acute neurologic complications, including subdural empyema and multiple cerebral infarcts (57%), hydrocephalus (36%), ventriculitis (29%), and cerebral venous sinus thrombosis (21%). Four patients (28.5%) died due to Salmonella meningitis complications. Four patients survived with full recovery. Six patients (60%) had long-term neurologic complications. Hydrocephalus, cerebral palsy, developmental delay, and epilepsy occurred in five, four, three, and three patients, respectively. Conclusion Salmonella meningitis results in significant mortality and adverse neurodevelopmental outcomes. The probability of relapse after an apparent recovery should be considered. Consensus on antibiotic treatment for Salmonella meningitis is needed.

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“…are a facultative intracellular bacteria and the wrong penetration of the antimicrobial into cells promotes the spread of the organism and the emergence of antibiotic resistance. Due to its bioavailability characteristics, third-generation cephalosporins such as cefotaxime, ceftriaxone, or ceftazidime are considered the treatment of choice, with a minimum duration of 3-4 weeks to prevent relapses, which have been described in 60% of cases [13]. Use of fluoroquinolones has also been documented, especially in cases of treatment failure or relapse after initial treatment with cephalosporins, both associated with them or as monotherapy [14, 15].…”

Section: Discussionmentioning

confidence: 99%

Meningitis Caused by Salmonella Newport in a Five-Year-Old Child

Malet¹,

Ingerto²,

Nieto-Gañán

2016

Case Reports in Infectious Diseases

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Salmonella Newport is a Gram-negative bacillus belonging to the Enterobacteria family and the nontyphi Salmonella (NTS), usually related to gastroenteritis. Main difference between NTS and Salmonella typhi is that the last one evolves to an invasive disease easier than NTS. These can progress to bacteremias in around 5% of cases and secondary focuses can appear occasionally, as in meningitis. An infection of the central nervous system is uncommon, considering its incidence in 0.6–8% of the cases; most of them are described in developing countries and mainly in childhood, especially neonates. Bacterial meningitis by NTS mostly affects immunosuppressed people in Europe. Prognosis is adverse, with a 50% mortality rate, mainly due to complications of infection: hydrocephalus, ventriculitis, abscesses, subdural empyema, or stroke. Choice antibiotic treatments are cefotaxime, ceftriaxone, or ceftazidime. The aim of this paper is to present a case of meningitis caused by Salmonella Newport diagnosed in a five-year-old girl living in a rural area of the province of Ourense (Spain), with favorable evolution and without neurological disorders.

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Salmonella meningitis following treatment of enteritis with neomycin

Abstract: SummaryA case of salmonella meningitis with accompanying septicaemia and pericarditis is reported in an adult following an episode of enteritis.

Cited by 12 publications

References 9 publications

Salmonella Meningitis in an Immunocompetent Adult

Salmonella Meningitis in an Immunocompetent Adult

Clinical Characteristics, Acute Complications, and Neurologic Outcomes of Salmonella Meningitis in Saudi Infants and Children

Meningitis Caused by Salmonella Newport in a Five-Year-Old Child

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