Salivary stimulation-could it play a role in GERD management?

Burgess, Jamie

doi:10.15406/joentr.2018.10.00328

Cited by 3 publications

(3 citation statements)

References 27 publications

(16 reference statements)

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“…63 Furthermore, various chronic medical disorders and medications that reduce salivary secretion have been associated with increased reflux episodes and subsequent development of esophageal reflux disease. 64 Esophageal dysmotility. The relationship between esophageal dysmotility and GERD has been well studied, with findings that suggest a bidirectional influence.…”

Section: Salivary Gland Secretionsmentioning

confidence: 99%

Pathophysiology and treatment options for gastroesophageal reflux disease: looking beyond acid

Sharma

Yadlapati

2020

Annals of the New York Academy of Sciences

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Gastroesophageal reflux disease (GERD) is a disorder due to the retrograde flow of refluxate into the esophagus. Although GERD is a common clinical diagnosis, its pathogenesis is quite complex. As a result of its multifactorial development, many patients continue to experience adverse symptoms due to GERD despite prolonged acid suppression with proton pump inhibitor therapy. The pathogenesis of GERD involves an interplay of chemical, mechanical, psychologic, and neurologic mechanisms, which contribute to symptom presentation, diagnosis, and treatment. As such, GERD should be approached as a disorder beyond acid. This review will investigate the major factors that contribute to the development of GERD, including factors related to the refluxate, esophageal defenses, and factors that promote pathologic reflux into the esophagus. In reviewing GERD pathogenesis, this paper will highlight therapeutic advances, with mention of future opportunities of study when approaching GERD.

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Section: Salivary Gland Secretionsmentioning

confidence: 99%

Pathophysiology and treatment options for gastroesophageal reflux disease: looking beyond acid

Sharma

Yadlapati

2020

Annals of the New York Academy of Sciences

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“…The quantity of stimulated saliva at 5 min we found in our study was lower in GERD patients then in healthy individuals, although the mean value was in the normal range of 5–15 mL (1–3 mL/min) [ 33 ]. These results are consistent with current data from the literature.…”

Section: Discussionmentioning

confidence: 97%

“…Collaboration between physicians and dentists is strongly advocated to prevent or ameliorate possible adverse oral effects from both endogenous and exogenous acids, and to promote adequate saliva production in patients with GERD [ 41 ]. Numerous researches present the correlation between the values of salivary pH, the disturbances in salivary quantity, and the GERD symptoms [ 33 , 34 , 35 , 42 , 43 ]. Oral cavity diseases may be developed as a result of changes in the oral fluid characteristics, including pH, which can modify the properties of dental materials [ 1 , 44 , 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of Salivary pH, Buffer Capacity, and Flow in Patients with and without Gastroesophageal Reflux Disease

Bechir

Cuc

Tohati

et al. 2021

IJERPH

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The oral cavity has specific and individualized characteristics, with pH, saliva flow, buffer capacity, temperature, and microorganisms content influencing oral health. Currently, the prevalence of gastroesophageal reflux disease (GERD) is constantly increasing. The objective of this study was to evaluate and compare the saliva quantity at 5 min, salivary pH, and salivary buffer capacity in patients with and without GERD, necessary for establishing the correct dental treatment plan. A Saliva-Check Buffer (GC) kit was used for the determination of salivary variables. The total number of 80 patients included in the study were divided into a study group and a control group, each containing 40 patients. Saliva quantity at 5 min was lower in patients suffering from GERD. The salivary pH of these patients turned to acid values compared to the salivary pH of controls, where the values were within the normal range. In patients with GERD, the determined salivary buffer capacity was low or very low. The use of the Saliva-Check Buffer (GC) kit is a simple, easy, non-invasive and patient-accepted method, which can also be used in the dentist’s office to assess the saliva buffer capacity and pH, variables that are important for establishing a correct dental treatment plan.

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Extraesophageal Manifestations and Symptoms of Esophageal Diseases

Širić¹,

Rosso²,

Včev³

2021

Esophagitis and Gastritis - Recent Updates

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Esophageal diseases are diagnosed by gastroenterological processing indicated due to typical gastrointestinal symptoms, but typical gastrointestinal symptoms are not the only possible manifestation of esophageal disease. There are also external symptoms such as chronic cough, laryngitis, pharyngitis, oropharyngeal dysphagia, odynophagia, laryngopharyngeal reflux, dysphonia, sinusitis, ear pain, and changes in laryngopharyngeal mucosa (erythema, edema, ventricular obliteration, cricoid hyperplasia and pseudosulcus). Extraesophageal symptoms are common in esophagitis and GERD, and studies show increasing prevalence of LPR in patients with GERD, as well as an association of reflux disease with cough and dysphonia symptoms. The aim of the chapter is to describe these extraesophageal symptoms of esophageal disease and how to recognize and treat them, in order to facilitate gastroenterologists’ diagnostic processing of patients with these symptoms, improve their treatment and assessment of the therapy effectiveness, prevent the development of stronger symptoms, and encourage multidisciplinary cooperation and exchange of knowledge, scientific and clinical work.

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Salivary stimulation-could it play a role in GERD management?

Cited by 3 publications

References 27 publications

Pathophysiology and treatment options for gastroesophageal reflux disease: looking beyond acid

Pathophysiology and treatment options for gastroesophageal reflux disease: looking beyond acid

Comparative Study of Salivary pH, Buffer Capacity, and Flow in Patients with and without Gastroesophageal Reflux Disease

Extraesophageal Manifestations and Symptoms of Esophageal Diseases

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