Salivary secretory IgA concentration and dental caries in children with Down syndrome

Hashizume, Lina Naomi; Schwertner, Carolina; Moreira, Maurício José Santos; Coitinho, Adriana Simon; Schüler‐Faccini, Lavínia

doi:10.1111/scd.12222

Cited by 14 publications

(31 citation statements)

References 24 publications

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“…The present analysis was undertaken to explicate on the investigation and possible determination of sIgA as a useful biomarker for dental caries in DS children. Various studies have predicated a lower prevalence of dental caries in DS children as compared with their normal counterparts, [2][3][4][5]8,17,25 included in this analysis. [2][3][4]8,10 The occurrence of dental caries and levels of sIgA in children with DS is ascertained, compared with matching controls to balance for confounders.…”

Section: Discussionmentioning

confidence: 99%

“…All studies (n = 9) included in systematic review were observational studies, in which one study was cross-sectional study, 21 one was interventional study, 22 and seven were case-control studies. 2,3,8,10,[23][24][25] These studies were from Israel, 21,23,24 Korea, 10 Turkey, 2 Portugal, 3 Spain, 22 New Zealand, 25 and Brazil. 8 In all of these studies, the number of participants ranged from 23 to 143 individuals with age range of 2 to 26 years.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…[5][6][7] It has also been determined that this could be due to various environmental factors 8 and a different salivary composition with altering flow rates. [8][9][10] Saliva plays a major role in the prevention of dental caries, essentially being one of its functions. Salivary pH ranges between 6.2 and 7.6, maintained near neutrality with the average pH of saliva being 6.7.…”

Section: Introductionmentioning

confidence: 99%

“…15,16 Saliva contains a host of antimicrobial factors including enzymes and antibodies such as salivary immunoglobulin A (sIgA). 8 It is reported that sIgA is one of the main immunoglobulins in the line of defense against pathogens invading mucosal surfaces, 17 enhancing oral immunity by preventing microbial adhesion and bacterial colonization. 5,8 Several studies have similarly demonstrated that the presence of high numbers of sIgA correlates with a low incidence of dental caries.…”

Section: Introductionmentioning

confidence: 99%

“…8 It is reported that sIgA is one of the main immunoglobulins in the line of defense against pathogens invading mucosal surfaces, 17 enhancing oral immunity by preventing microbial adhesion and bacterial colonization. 5,8 Several studies have similarly demonstrated that the presence of high numbers of sIgA correlates with a low incidence of dental caries. [17][18][19] To the best of our knowledge, however, there has been no previous review investigating the role of sIgA as an indicator for dental caries in patients of DS, as it can be a very useful biomarker for dental caries occurrence in individuals of DS moving toward prevention and oral care.…”

Section: Introductionmentioning

confidence: 99%

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Salivary IgA as a Useful Biomarker for Dental Caries in Down Syndrome Patients: A Systematic Review and Meta-analysis

et al. 2020

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The objective of this systematic review and meta-analysis is to critically analyze and summarize studies reporting association of salivary immunoglobulin A (IgA) levels as a biomarker for dental caries in Down syndrome (DS) patients. Using the keywords salivary [All Fields] AND IgA [All Fields] AND (“down syndrome” [MeSH Terms] OR (“down”[All Fields] AND “syndrome” [All Fields]) OR “down syndrome” [All Fields]), an electronic search was conducted via PubMed and Scopus databases by two authors, H. H. and Z. K. independently. Retrieved studies were screened against the predefined exclusion and inclusion criteria. To estimate the risk of bias, quality assessment of included studies was carried using the Newcastle–Ottawa quality assessment scale for observational studies. Primary search resulted in 10 articles from PubMed and 13 articles from Scopus. Ten studies fulfilled the defined selection criteria and evaluated the salivary IgA (sIgA) level in DS patients with dental caries. Five articles were further analyzed in a quantitative synthesis presented in the meta-analysis. Due to a modified lifestyle and compromised oral hygiene in DS patients, understandably, it is still postulated in the literature that the presence of sIgA can have a protective effect on the occurrence of dental caries as compared with healthy counterparts. As indicated by the present meta-analysis, no conclusions can be drawn as to definitively label sIgA as a biomarker for dental caries. Further, well-designed longitudinal clinical studies and translational research are therefore required before the benchmarking of sIgA as a useful biomarker for dental caries in DS patients with preferable molecular insights.

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