Salivary Proteins—A Barrier on Enamel Demineralization: An <i>in vitro</i> Study

Hegde, Mithra N; Sajnani, Ankit Rajesh

doi:10.5005/jp-journals-10005-1398

Cited by 9 publications

(6 citation statements)

References 21 publications

(27 reference statements)

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“…In the artificial saliva and acetic acid control group, dental hardness is increased, but not as high as those in the presence of nano chitosan and calcium pretreatment. This is because of the fact that saliva itself can affect the remineralization of enamel (Hegde and Sajnani, 2017). This is proven by the value of dental hardness in the group given acetic acid which was also increased, but not as high as the saliva group.…”

Section: Discussionmentioning

confidence: 99%

Pretreatment Of Nano Chitosan And Nano Calcium (X. gideon) In The Application Of Acetic Acid To Enamel Hardness

Komariah

Parcelia

Trenggono

2019

Int. J. Adv. Biol. Biomed. Res.

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Background: Chitosan and Calcium can be regarded as the natural polymeric materials obtained from the exoskeleton of Xylotrupes gideon through demineralization, deproteinization and deacetylation processes. Nano chitosan and calcium can inhibit the demineralization process, which is caused by the consumption of acetic acid. This study aims at determining the effect of nano chitosan pretreatment and nano calcium X. gideon on the application of acetic acid toward tooth enamel hardness. Methods: The study used 36 upper teeth premolars divided into 4 groups; the first group was artificial saliva control, the second group was acetic acid application without pretreatment with nano chitosan and nano calcium, the third group was given pretreatment with nano chitosan and the fourth group was given pretreatment with nano chitosan and nano calcium (5:1). Results: The results showed that there were significant differences in all groups both without or with nano chitosan pretreatment and combination nano chitosan and nano calcium X. gideon on the application of acetic acid to hardness of tooth enamel (p <0.05). Conclusions: Research using combination of nano chitosan and nano calcium proved to be more effective in inhibiting the demineralization process by increasing the hardness of tooth enamel as compared to other groups.

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Section: Discussionmentioning

confidence: 99%

Pretreatment Of Nano Chitosan And Nano Calcium (X. gideon) In The Application Of Acetic Acid To Enamel Hardness

Komariah

Parcelia

Trenggono

2019

Int. J. Adv. Biol. Biomed. Res.

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“…Besides saliva, dental pellicle is another key biological factor that can influence oral hygiene, the mucins, firmly settle on the crystal surface, and create a protective layer. This protective layer of mucous molecules binds water and ions and holds them in place [ 24 , 25 ]. The noncellular glycoprotein film layer of adsorbed salivary proteins and other macromolecules on the dental enamel surface protects the enamel and serves as a diffusion barrier.…”

Section: Discussionmentioning

confidence: 99%

Association of Salivary Statherin, Calcium, and Proline-Rich Proteins on Oral Hygiene: A Cross-Sectional Study

Pateel

Gunjal

Fong

et al. 2021

International Journal of Dentistry

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Background. Saliva, as a complex biofluid, plays a pivotal role in maintaining oral health and tooth integrity. There has been inconsistent data available on the relationship between salivary parameters and oral health. This study aims to investigate the association between salivary statherin, acidic proline-rich proteins (aPRP), and calcium with oral hygiene status. Methods. One hundred and eighty-eight healthy subjects aged between 18 and 50 years with varying oral hygiene status who gave consent to participate were included in this cross-sectional study. The subjects were recruited from primary oral health care of MAHSA University. Oral hygiene of all the participants was measured using Oral Hygiene Index–Simplified (OHI-S). Stimulated saliva collected using paraffin wax was analyzed for salivary statherin, aPRP, and calcium. The relationship between salivary statherin, aPRP, and calcium levels with OHI-S was assessed using Spearman’s Rank correlation coefficient; the strength of relationship was assessed by multiple linear regression analysis. Results. The study found a weak positive correlation (r = 0.179, p = 0.014) between salivary statherin and OHI-S; weak negative correlation (r = −0.187, p = 0.010) between salivary aPRP and OHI-S; and moderate negative correlation between salivary statherin and salivary aPRP levels (r = −0.50, p < 0.001) which were statistically significant. Conclusion. Poor oral hygiene is associated with increased statherin and reduced aPRP levels in saliva. Thus, these salivary components may have a role in predicting oral hygiene status.

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“…Saliva plays a protective role against the demineralization process, which can be in the form of reduction in tooth surface demineralization rate, and enhances the remineralization [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…The remineralization process can be achieved by replacing the minerals in a demineralized enamel or producing amorphous mineral precipitates in the interrod and intercrystal spaces [ 14 ]. Also, remineralization can happen naturally via saliva or be induced by using therapeutic agents [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

A Comparison between Two Different Remineralizing Agents against White Spot Lesions: An In Vitro Study

Alsubhi

Gabbani

Alsolami

et al. 2021

International Journal of Dentistry

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Enamel demineralization and white-spot lesions (WSLs) around the orthodontic brackets are common clinical complications after orthodontic fixed appliance therapy. WSLs form mainly due to plaque deposition around the brackets during the orthodontic treatment period. This study was designed to compare and evaluate the efficacy of two different remineralization agents on WSLs, which are “Clinpro 5000 and Colgate Sensitive Pro-Relief”. 27 caries-free human premolar teeth were collected after extraction for orthodontic purposes. The crowns were set in acrylic resin, and the entire surfaces were coated with nail varnish apart from an area of 4 × 4 mm on the buccal surface. The surface microhardness (SMH) was measured using the Vickers microhardness testing machine at baseline, after demineralization, and after treatment. Then, the different SMH values were statistically analyzed using mixed-effects linear regression. All samples were immersed in demineralizing solution for ten days to create WSLs, and then the teeth were allocated randomly into one of the three groups: Group 1 (control group-immersed in artificial saliva), Group 2 (treated with Colgate sensitive Pro-Relief toothpaste), and Group 3 (Clinpro 5000 toothpaste). Cycles of treatment were done for 5 minutes every 12 hours for 14 days. The samples were stored in freshly prepared artificial saliva between cycles. The mixed-effects model was used to quantify the effect of different remineralization agents. All statistics were computed using STATA software (version14.1; Stata, College Station, TX). All statistical tests were two-tailed and interpreted at the 0.05 significance level. Both agents improved the surface hardness. Clinpro 5000 improved the surface hardness by 12.7 ( P value 0.012), and Colgate Sensitive Pro-Relief improved surface hardness by 18.2 ( P value <0.0001), However when both treatments are compared with each other, there was no statistical significance among them. When compared to the control group, both treatments “Clinpro™ 5000 and Colgate Sensitive Pro-Relief” have significantly improved enamel’s SMH.

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Salivary Proteins—A Barrier on Enamel Demineralization: An in vitro Study

Cited by 9 publications

References 21 publications

Pretreatment Of Nano Chitosan And Nano Calcium (X. gideon) In The Application Of Acetic Acid To Enamel Hardness

Pretreatment Of Nano Chitosan And Nano Calcium (X. gideon) In The Application Of Acetic Acid To Enamel Hardness

Association of Salivary Statherin, Calcium, and Proline-Rich Proteins on Oral Hygiene: A Cross-Sectional Study

A Comparison between Two Different Remineralizing Agents against White Spot Lesions: An In Vitro Study

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