Salivary levels of calcium, phosphorus, potassium, albumin and correlation with serum biomarkers in hemodialysis patients

Salivary levels of phosphorus and urea as indices of their plasma levels in nephropathic patients

“…Data in the group of CKD patients together with the subset of pre‐dialysis and post‐dialysis data coherently indicated that saliva phosphorus was several times higher than plasma phosphorus and positively correlated with plasma phosphorus. The finding of a positive correlation between saliva phosphorus and plasma phosphorus was in accordance with the conclusions of the study by Savica et al where samples were collected after an overnight fast but was in contrast with the conclusions of the study by Rodrigues et al where samples were collected after 1‐hour fast . The past observation of absent correlation using samples collected after 1‐hour fast together with the present observation of reduced saliva phosphorus three hours after breakfast supported the interpretation that the lack of correlation in the study of Rodrigues et al could reflect the confounding of a short fasting before the collection of saliva samples.…”

“…The use of saliva for laboratory tests has been investigated in various medical areas because saliva could be used as a noninvasive diagnostic tool . An important prerequisite for the use of saliva in diagnostic workup is that the salivary levels of the marker associated with a given disorder should mirror the profile of the marker in biological samples used as gold standard in medical practice.…”

“…An important prerequisite for the use of saliva in diagnostic workup is that the salivary levels of the marker associated with a given disorder should mirror the profile of the marker in biological samples used as gold standard in medical practice. Previous observations indicated that correlations between plasma concentrations and saliva concentrations are detectable for some but not for all analytes . It is well established that small molecules as phosphorus and urea are measurable in saliva .…”

“…As part of a project about the use of saliva tests in space medicine, this study investigated methodological aspects in saliva measurements (duplicate samples, saliva from different sites of collection, day‐to‐day variability, time of collection, effects of freezing/thawing) and correlations between plasma concentrations and saliva concentrations. Methodological aspects were investigated in healthy volunteers, whereas plasma‐saliva correlations were investigated in patients with kidney disease because low kidney function increases the levels of phosphorus and urea not only in plasma but also in saliva …”

Differences in Dental Calculus Indices and Salivary Calcium and Phosphate Levels in Children With Chronic Kidney Disease Undergoing Hemodialysis and Peritoneal Dialysis Therapy

“…The type of dialysis may also be an important factor in the adequacy of Ca and P control in dialysis patients [9]. Alteration of the composition of salivary secretion may be correlated with serum biomarkers in dialysis patients [10]. The present study aimed to analyze dental calculus indices and salivary Ca and P levels in a group of children with CKD undergoing HD therapy and another group undergoing PD therapy.…”