Salivary levels of calcium and phosphorus in children with and without early childhood caries: A pilot study

Aruna, S.; Meenakshi, B; Kv, Rama; Valarmathi, S

doi:10.4103/srmjrds.srmjrds_5_20

Cited by 5 publications

(7 citation statements)

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“…Other investigators have reported a slightly higher expression in caries-free children compared to those with this disease. These authors include [ 40 ], who analysed saliva samples from 75 children between 3 and 5 years of age, [ 31 ], in saliva from 40 children and adolescents, and [ 41 ], in 90 children from 3 to 6 years of age. [ 7 ], detected a significantly higher expression of this component in caries-free adults after rinsing with a sugar solution.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of possible biomarkers for caries risk in children 6 to 12 years of age

Díaz

Simón-Soro

Forero

et al. 2021

Journal of Oral Microbiology

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Background: Electrolytes, proteins, and other salivary molecules play an important role in tooth integrity and can serve as biomarkers associated with caries. Objective: To determine the concentration of potential biomarkers in children without caries (CF) and children with caries (CA). Methods: Unstimulated saliva was collected, and the biomarkers quantified in duplicate, using commercial Enzyme Linked Immunosorbent Assay (ELISA) kits to determine IgA, fibronectin, cathelicidin LL-37, and statherin levels, as well as colorimetric tests to detect formate and phosphate. Results: Significantly higher concentrations of statherin was detected in the CF group (Median: 94,734.6; IQR: 92,934.6–95,113.7) compared to the CA2 group (90,875.0; IQR: 83,580.2–94,633.4) (p = 0.03). Slightly higher median IgA (48,250.0; IQR: 31,461.9–67,418.8) and LL-37 levels (56.1; IQR 43.6–116.2) and a lower concentration of formate were detected in the CF group (0.02; IQR 0.0034–0.15) compared to the group with caries (IgA: 37,776.42; IQR: 33,383.9–44,128.5; LL-37: 46.3; IQR: 40.1011–67.7; formate: 0.10; IQR: 0.01–0.18), but these differences were not statistically significant. Conclusion: The fact that these compounds have been identified as good markers for caries among European adults highlights the difficulty of identifying universal biomarkers that are applicable to all ages or to different populations.

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Section: Discussionmentioning

confidence: 99%

Evaluation of possible biomarkers for caries risk in children 6 to 12 years of age

Díaz

Simón-Soro

Forero

et al. 2021

Journal of Oral Microbiology

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“…Also, lower calcium and phosphorus levels have been seen in previous studies in children with high caries incidence. 8,33 After the cariogenic challenge, the consumption of paneer showed a significant rise in calcium and phosphorus values in our study after 10 minutes itself which could be due to the higher levels of calcium and phosphorus in paneer. This correlates with the study by Ravishankar et al 32 and Moynihan et al 18 Kashket and DePaola stated that milk products increase the calcium and phosphorus level in plaque thus diminishing demineralization and favoring remineralization.…”

Section: Discussionmentioning

confidence: 52%

“…Also, lower calcium and phosphorus levels have been seen in previous studies in children with high caries incidence. 8 33…”

Section: Discussionmentioning

confidence: 99%

“…7 Research has shown that reduced calcium, phosphorus, and pH levels are associated with a higher prevalence of caries. 8,9 Saliva has various protective antioxidant mechanisms which prevent formation of free radicals and repair oxidative damage caused by bacteria. Imbalance in levels of free radicals, reactive oxygen species, and antioxidants in saliva play an essential role in the onset and development of dental caries.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Cariogenic Potential and Total Antioxidant Capacity of Saliva after the Consumption of Candies and Paneer: An In Vivo Study

Shah

Manju

Joshi³

et al. 2022

Journal of Health and Allied Sciences NU

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Aim The present study was performed to assess and compare the changes in pH, calcium, phosphorus, alkaline phosphatase, and the total antioxidant capacity (TAC) of saliva after consuming candies, followed by rinsing with water and consumption of paneer. Materials and Methods Baseline saliva of 5 mL was collected from 60 children and they were asked to chew on candies. After 10 minutes of intake of candies, 5 mL of saliva was collected. They were then divided into two groups of 30 each and test products were given. Group 1: rinse with water and group 2: chew 20 g of paneer and swallow. Saliva of % mL was collected after 10, 20, and, 30 minutes from the study groups. The saliva samples collected were assessed for pH, calcium, phosphorus, alkaline phosphatase, and TAC. The data were analyzed using the paired t-test and post hoc Tukey's test. Results The pH, calcium, phosphorus, and alkaline phosphatase decreased from baseline values after consuming candies significantly (p < 0.001). These increased after rinsing with water and consumption of paneer which was statistically significant (p < 0.001). The TAC values increased significantly after consuming candies and decreased after rinsing with water and consumption of paneer which was substantial for both the groups. Conclusion Consumption of candies created a cariogenic milieu. Both the study groups were effective in the reversal of the cariogenic potential. The consumption of paneer caused remineralizing properties and showed superior results than rinsing with water.

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“…Additionally, Aruna et al (31) , reported that the levels of calcium were found to be higher in patients who were free from caries as compared to those children with severe early childhood caries. This agreed with the results of this study whereas a significant difference in calcium level between the children with ECC and children with caries-free.…”

Section: Discussionmentioning

confidence: 99%

Relation between Serum level of calcium, phosphorus, and vitamin D and early childhood caries.

Abdel-Hay

Ismai

Abbas

et al. 2021

Al-Azhar Journal of Dental Science

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Objective: Early Childhood Caries (ECC) considers a multifactorial disease. Vitamin D, calcium, and phosphorus have a crucial role in mineralized tissue formation and mineralization. The purpose of this study was to evaluate the association between the serum level of vitamin D, calcium, and phosphorus, and ECC in healthy preschool children. Subject and methods: Thirtysix preschool children with ages from 1 to 6 years old were selected for this clinical study. Enrolled children were randomly divided into two equal groups (n=18); group I; children with ECC, group II; children with caries-free. Clinical examination was carried out to assess decay, missing, filled teeth (dmft) caries index using World Health Organization (WHO) criteria. 25-hydroxyvitamin D "25(OH)D", calcium, and phosphorus in serum had been measured for all enrolled children. Results:The results of this study showed a significant decrease in serum level of vitamin D, calcium, and phosphorus in children with ECC when compared to children with caries-free. However, the result of the dmft index revealed that the filled tooth due to caries showed a higher mean followed by decay and missing teeth. Conclusion: There is a relation between the deficiency in serum level of vitamin D, calcium, and phosphorus and the incidence of ECC.

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Salivary levels of calcium and phosphorus in children with and without early childhood caries: A pilot study

Cited by 5 publications

References 1 publication

Evaluation of possible biomarkers for caries risk in children 6 to 12 years of age

Evaluation of possible biomarkers for caries risk in children 6 to 12 years of age

Evaluation of the Cariogenic Potential and Total Antioxidant Capacity of Saliva after the Consumption of Candies and Paneer: An In Vivo Study

Relation between Serum level of calcium, phosphorus, and vitamin D and early childhood caries.

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