Salivary lactoferrin in HIV-infected children: Correlation with Candida albicans carriage, oral manifestations, HIV infection and its antifungal activity

Alves, Thais Pinto; Simões, Ana Clara Duarte Correa; Soares, Rosângela Maria de Araújo; Moreno, Daniela; Portela, Maristela Barbosa; Castro, Glória Fernanda Barbosa de Araújo

doi:10.1016/j.archoralbio.2014.04.010

Cited by 18 publications

(18 citation statements)

References 30 publications

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“…The significant differences established in present study in the salivary LF concentration in patients with different levels of Candida spp. before prosthetic treatment are corresponding with the results reported by Alves et al (10). Our results did not establish relation between level of LF and species of Candida.…”

Section: Discussionsupporting

confidence: 86%

Levels of sIgA and LF against Candida spp. in the saliva of patients with complete dentures, lined with silicone-based elastic materials

Yankova¹,

Lozanova²,

Vasileva³

et al. 2018

MedInform

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Introduction: Totally edentulous patients require a specific approach to prosthetic treatment, due to presence of excessive bone resorption, painful neurogenic spots and thin mucosa. One possible approach to treatment is application of complete dentures, lined with elastic materials. The porous structure of these materials is a prerequisite for bacterial and fungal colonization in oral cavity. The saliva flow, through its cleansing and antibacterial action, partly regulates this process due to the presence of histidine-rich peptides, peroxidase system, lysozyme, lactoferrin, slgA etc. Aim: Investigation of the relation between sIgA or LF levels and the type and amount of Candida spp. in saliva of totally edentulous patients, treated with conventional and two-layer complete dentures. Material and methods: 43 totally edentulous patients at the average age of 68.4 ± 9.94 years were treated with conventional complete dentures and with complete dentures, lined with silicone-based elastic materials. In relation to Candida spp. presence in the saliva, the patients were divided into three groups, as follows: without Candida presence, with norm/light presence and with moderate/heavy presence of Candida spp. The salivary levels of LF, sIgA, and the amount and type of Candida spp. were examined before and after prosthetic treatment. Results: We found dependence between LF levels and the type and amount of Candida spp. in saliva. The increase of LF concentration was established in the presence of non-albicans Candida and in the presence of Candida spp in levels below and above 10 4 CFU/ml in saliva. Such dependence at sIgA levels was not detected. Conclusion: Despite the major role of sIgA in the mucosal immune system, its levels were not dependent on the type and amount of Candida spp. in saliva, unlike those of LF.

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Section: Discussionsupporting

confidence: 86%

Levels of sIgA and LF against Candida spp. in the saliva of patients with complete dentures, lined with silicone-based elastic materials

Yankova¹,

Lozanova²,

Vasileva³

et al. 2018

MedInform

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“…Moreover, Alves et al. () found that HIV‐infected pediatric patients with Candida species oral infection had elevated salivary LF levels (Alves et al., ). However, in 2014, Ferreira et al.…”

Section: Lf Snps and Hiv1mentioning

confidence: 99%

Role of lactoferrin and lactoferrin‐derived peptides in oral and maxillofacial diseases

et al. 2018

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The oral cavity harbors different taxonomic groups, the evolutionary coexistence of which develops the oral ecosystem. These resident microorganisms can alter the balance between the physiologic and pathologic conditions that affect the host, both locally and systemically. This highly sophisticated nature of the oral cavity poses a significant therapeutic challenge. Numerous human and animal studies have been conducted to potentiate the efficacy and competence of current treatments of pathologic conditions as well as to develop novel therapeutic modalities. One of these studies is the use of the potent antimicrobial agent lactoferrin (LF), which was originally derived from the host immune system. LF is an 80-kDa glycoprotein that has a free iron sequestration mechanism with evident antimicrobial, anti-tumor, and immunomodulatory properties. A wide range of active peptides have been isolated from the N-terminal region of LF, which possess antimicrobial activities. In this review, we discuss the role of LF and LF-derived peptides under a heterogeneous group of oral and maxillofacial conditions, including bacterial, fungal, viral infections; head and neck cancers; xerostomia; and implantology-bone-related manifestations.

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“…Saliva contains antimicrobial proteins which inhibit microbial colonization (Alves et al, 2014;(Nittayananta, Kemapunmanus, Amornthatree, Talungchit, & Sriplung, 2014); Khan et al, 2013). Human β-defensins (hBD) are produced by epithelial cells in the buccal mucosa, gingiva, tongue, salivary glands and other parts of the mouth (Diamond & Ryan, 2012;Chung, Dommisch, Yin, & Dale, 2007;Abiko, Nishimura, & Kaku, 2003).…”

Section: Introductionmentioning

confidence: 99%

Immunological and epidemiological factors affecting candidiasis in HIV patients beginning antiretroviral therapy in an Asian clinic

Wulandari

Saraswati

Adawiyah

et al. 2017

Archives of Oral Biology

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Salivary lactoferrin in HIV-infected children: Correlation with Candida albicans carriage, oral manifestations, HIV infection and its antifungal activity

Cited by 18 publications

References 30 publications

Levels of sIgA and LF against Candida spp. in the saliva of patients with complete dentures, lined with silicone-based elastic materials

Levels of sIgA and LF against Candida spp. in the saliva of patients with complete dentures, lined with silicone-based elastic materials

Role of lactoferrin and lactoferrin‐derived peptides in oral and maxillofacial diseases

Immunological and epidemiological factors affecting candidiasis in HIV patients beginning antiretroviral therapy in an Asian clinic

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