Immunological and epidemiological factors affecting candidiasis in HIV patients beginning antiretroviral therapy in an Asian clinic

Wulandari, Endah; Saraswati, Henny; Adawiyah, Robiatul; Djauzi, Samsuridjal; Wahyuningsih, Retno; Price, Patricia

doi:10.1016/j.archoralbio.2017.05.021

Cited by 6 publications

(9 citation statements)

References 29 publications

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“…Overall, the three most common oral thrush lesions reported in SEA studies (13 cohorts; Consistent with other studies, several SEA studies reported the detection of pseudomembranous candidiasis as a prognostic indicator for advancing HIV infection. 7,26 These findings are almost similar to studies in other geographical region, 9 whereby erythematous candidiasis (24%), pseudomembranous candidiasis (14%) and angular cheilitis (6%) have been identified as the most prevalent oral thrush manifestations in HIV-infected individuals.…”

Section: Clini C Al Fe Ature S Of or Al Thrus H Le S I On Ssupporting

confidence: 88%

“…The speciation of Candida yeasts in oral thrush patients was only reported in three out of 22 SEA studies reviewed in this paper (Table 1). 18,24,26 C. albicans was identified as the most common species in all studies, except in a Cambodian study, whereby C. tropicalis and C. krusei were identified as the most common oral pathogens in HIV-infected patients with and without antifungal treatment, and healthy individuals. 24 C. tropicalis, C. glabrata and C. krusei were regarded as rare isolates obtained from prenatally HIV-infected and HIV-negative children with oral candidiasis.…”

Section: De Termination Of or Al Ca Nd Ida C Arriag E R Ate Smentioning

confidence: 98%

“…An Indonesian study described no significant association between oral pharyngeal candidiasis and oral hygiene. 26 Interestingly, it was found that the levels of salivary β-defensin-2 might have an association with oral pharyngeal candidiasis in HIV-infected patients responding to HAART. In another study, tuberculosis (TB) and HIV coinfections were common risk factors for oral candidiasis (53.7%).…”

Section: In Ciden Ce Of or Al Thrus Hmentioning

confidence: 99%

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Revisiting oral thrush in South‐East Asian patients: A review of published studies (2000–2020)

Karajacob

Al-Maleki

Tay

2021

J Oral Pathology Medicine

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The human oral cavity is a niche for abundant and distinct microbial communities, and the second most microbial-complex anatomic site after the gut system. 1 The oral microbiome has been linked to a variety of oral diseases that affect over 3-5 billion people globally. 2 Surveillance for oral diseases has increased with the growing burden of non-communicable diseases (eg diabetes and cancer). 3 In the current human immunodeficiency virus (HIV) epidemic, 30%-80% of HIV-positive individuals still develop oral manifestations, despite the

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Section: Clini C Al Fe Ature S Of or Al Thrus H Le S I On Ssupporting

confidence: 88%

Section: De Termination Of or Al Ca Nd Ida C Arriag E R Ate Smentioning

confidence: 98%

Section: In Ciden Ce Of or Al Thrus Hmentioning

confidence: 99%

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Revisiting oral thrush in South‐East Asian patients: A review of published studies (2000–2020)

Karajacob

Al-Maleki

Tay

2021

J Oral Pathology Medicine

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“…The JakCCANDO study conducted in Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia ( Wulandari et al., 2017 ) recruited 82 adults with horizontally-acquired HIV infection ( Estiasari et al., 2015 , 2020 ), with <200 CD4 T-cells/μl, a Karnofsky performance score 70–100, living in Jakarta, and providing written and informed consent to participate in the study. Participants with a history of head injury, stroke, recurrent seizures, severe depression (Hamilton Depression Scale) ( Estiasari et al., 2015 ), neurological deficits which may interfere with neurocognitive evaluation, pregnancy, breastfeeding and current use of illicit drugs were excluded.…”

Section: Methodsmentioning

confidence: 99%

Neurocognitive outcomes in indonesians living with HIV are influenced by polymorphisms in the gene encoding purinergic P2X receptor 7

Gaff

Estiasari

Diafiri

et al. 2021

Brain, Behavior, & Immunity - Health

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The advent of effective antiretroviral therapy (ART) has decreased the prevalence and severity of HIV-associated neurocognitive disorders (HAND), but milder forms of HAND remain despite optimal treatment. Neuronal injury and loss due to inflammation may mediate HAND. P2X7R encodes purinergic P2X receptor 7 which influences neuroinflammatory pathways and carries polymorphisms associated with sensory neuropathy in HIV patients. We assessed associations between P2X7R polymorphisms and neurocognitive outcomes in Indonesian patients (n = 59) as they commenced ART and after 3, 6 and 12 months. Z-scores were calculated over 5 domains using local controls and evaluated as continuous variables. Optimal linear regression models identified polymorphisms influencing attention, memory, executive function, motor speed and total cognitive function at each time point. rs504677 was associated with lower executive and motor speed Z-scores at 0, 3, 6, and 12 months, and with memory at 0 and 12 months. Memory was positively influenced by carriage of the rs208296 minor allele at 0, 3 and 6 months and by carriage of the rs208307 minor allele at 0 and 12 months. Higher attention Z-scores associated with carriage of minor alleles of rs1653598 after 0 and 12 months. These also positively influenced executive function and motor speed after 0–6 months. This study identifies polymorphisms in P2X7R which influence domain-specific neurocognitive outcomes in HIV+ Indonesians prior to and shortly after commencing ART. This implicates purinergic P2X receptor 7 in the pathogenesis of HAND.

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“…Candida infection in HIV patients is one of the so-called AIDS-defining illnesses. In absence of antiretroviral therapy, 57% of patients develop oropharyngeal candidiasis, typically when T cell CD4 + count is below 200 cells/m 3 [ 62 ].…”

Section: Mucocutaneous Candidiasismentioning

confidence: 99%

Patient Susceptibility to Candidiasis—A Potential for Adjunctive Immunotherapy

Davidson

Netea

Kullberg

2018

JoF

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Candida spp. are colonizing fungi of human skin and mucosae of the gastrointestinal and genitourinary tract, present in 30-50% of healthy individuals in a population at any given moment. The host defense mechanisms prevent this commensal fungus from invading and causing disease. Loss of skin or mucosal barrier function, microbiome imbalances, or defects of immune defense mechanisms can lead to an increased susceptibility to severe mucocutaneous or invasive candidiasis. A comprehensive understanding of the immune defense against Candida is essential for developing adjunctive immunotherapy. The important role of underlying genetic susceptibility to Candida infections has become apparent over the years. In most patients, the cause of increased susceptibility to fungal infections is complex, based on a combination of immune regulation gene polymorphisms together with other non-genetic predisposing factors. Identification of patients with an underlying genetic predisposition could help determine which patients could benefit from prophylactic antifungal treatment or adjunctive immunotherapy. This review will provide an overview of patient susceptibility to mucocutaneous and invasive candidiasis and the potential for adjunctive immunotherapy.

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Immunological and epidemiological factors affecting candidiasis in HIV patients beginning antiretroviral therapy in an Asian clinic

Abstract: ART reduces the prevalence of OPC, and the total fungal and C. albicans burden. Levels of salivary β-defensin-2 may associate with OPC in HIV patients responding to ART.

Cited by 6 publications

References 29 publications

Revisiting oral thrush in South‐East Asian patients: A review of published studies (2000–2020)

Revisiting oral thrush in South‐East Asian patients: A review of published studies (2000–2020)

Neurocognitive outcomes in indonesians living with HIV are influenced by polymorphisms in the gene encoding purinergic P2X receptor 7

Patient Susceptibility to Candidiasis—A Potential for Adjunctive Immunotherapy

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