Salivary Fusobacterium nucleatum serves as a potential biomarker for colorectal cancer

Zhang, Xin; Zhang, Yaping; Gui, Xinru; Zhang, Zhenhong; Chen, Wendan; Zhang, Xiaowei; Wang, Yanxiang; Zhang, Mengjiao; Shang, Ziqi; Xin, Yiwei; Zhang, Yi

doi:10.1016/j.isci.2022.104203

Cited by 15 publications

(22 citation statements)

References 50 publications

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“…Another recent study in CRC found that F. nucleatum DNA was increased in saliva of CRC patients compared to healthy controls. Receiver operating characteristic curves revealed that F. nucleatum DNA was superior in diagnosing CRC compared to carcinoembryonic antigen and carbohydrate antigen 19-9, the most frequently used noninvasive biomarkers for CRC diagnosis [54 ▪▪ ]. Similar results were observed in gastric cancer, where a recent study reported that salivary F. nucleatum could be used as a potential biomarker for gastric cancer diagnosis [55 ▪ ].…”

Section: Fusobacteria As a Biomarker For Cancer Diagnosis And Prognosismentioning

confidence: 59%

The role of Fusobacteria in oral cancer and immune evasion

Harrandah

2023

Current Opinion in Oncology

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Purpose of reviewThere is growing evidence that suggests a possible role for bacteria in the progression of cancer. Fusobacteria have been detected in different types of cancers, including colorectal and oral cancers. Fusobacteria are common opportunistic oral bacteria known to cause various infections. In this review, we focus on the association between Fusobacteria and cancer, specifically oral cancer, and provide insight into the role of Fusobacteria in carcinogenesis and immune evasion.Recent findingsRecently, it has been suggested that Fusobacteria are among the bacteria that contribute to the progression of cancer and might affect disease prognosis and treatment outcome. Moreover, Fusobacteria might alter tumor microenvironment and have an impact on tumor immune response. Thus, understanding the effect of Fusobacteria on cancer cells and tumor microenvironment is crucial to improve treatment outcome.SummeryRecent evidences suggest that Fusobacteria not only have an impact on tumor progression, but might also affect tumor immune response. Moreover, Fusobacteria presence in the tumor microenvironment might have an impact on treatment outcome and might be used as a prognostic factor.

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Section: Fusobacteria As a Biomarker For Cancer Diagnosis And Prognosismentioning

confidence: 59%

The role of Fusobacteria in oral cancer and immune evasion

Harrandah

2023

Current Opinion in Oncology

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“…Secondly, reliable and rapid measurement methods to validate the feasibility of Fn as a biomarker are lacking. Considering that Fn may originate from the oral cavity and that saliva is readily available through non-invasive routes, Zhang et al [ 86 ] reported that salivary Fn DNA could be used as a biomarker for colorectal cancer diagnosis and prognosis. In their research, they discovered that CRC patients with regional lymph node metastasis and distant metastasis had increasing levels of salivary Fn DNA (median: 4.662 IQR, 5.856 IQR, respectively).…”

Section: Discussionmentioning

confidence: 99%

“…The sensitivity and specificity levels for CRC in the test cohort were 86.7% and 67.2%, respectively, when the cutoff value was 0.437. Zhang et al [ 86 ] also identified a total of 1287 differentially expressed mRNAs based on different Fn DNA concentrations. Measuring the levels of salivary Fn DNA and related mRNAs appears to be more sensitive and suitable model than in vitro experiments and animal models.…”

Section: Discussionmentioning

confidence: 99%

The Role of Fusobacterium nucleatum in Colorectal Cancer Cell Proliferation and Migration

Guo

et al. 2022

Cancers

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Colorectal cancer (CRC) is a common cancer worldwide with poor prognosis. The presence of Fusobacterium nucleatum (Fn) in the intestinal mucosa is associated with the progression of CRC. In this review, we explore the mechanisms by which Fn contributes to proliferation and migration of CRC cells from the following four aspects: induction of the epithelial–mesenchymal transition (EMT), regulation of the tumor microenvironment (TME), expression of oncogenic noncoding RNAs, and DNA damage. This review outlines the scientific basis for the use of Fn as a biomarker and therapeutic target in CRC.

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“…Compared to healthy controls, over-abundance of F . nucleatum was found in colorectal tissue biopsies [ 120 ] and saliva [ 121 ] in CRC patients. Identical strains of F. nucleatum were detected in their colorectal cancer and oral cavity, suggesting that F .…”

Section: Oral Microbiota Gut Microbiota and Systemic Diseasesmentioning

confidence: 99%

The interplay between oral microbiota, gut microbiota and systematic diseases

Tan

Wang²,

Gong

2023

Journal of Oral Microbiology

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Over the past two decades, the importance of microbiota in health and disease has become evident. The human gut microbiota and oral microbiota are the largest and second-largest microbiome in the human body, respectively, and they are physically connected as the oral cavity is the beginning of the digestive system. Emerging and exciting evidence has shown complex and important connections between gut microbiota and oral microbiota. The interplay of the two microbiomes may contribute to the pathological processes of many diseases, including diabetes, rheumatoid arthritis, nonalcoholic fatty liver disease, inflammatory bowel disease, pancreatic cancer, colorectal cancer, and so on. In this review, we discuss possible routes and factors of oral microbiota to affect gut microbiota, and the contribution of this interplay between oral and gut microbiota to systemic diseases. Although most studies are association studies, recently, there have been increasing mechanistic investigations. This review aims to enhance the interest in the connection between oral and gut microbiota, and shows the tangible impact of this connection on human health.

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Salivary Fusobacterium nucleatum serves as a potential biomarker for colorectal cancer

Cited by 15 publications

References 50 publications

The role of Fusobacteria in oral cancer and immune evasion

The role of Fusobacteria in oral cancer and immune evasion

The Role of Fusobacterium nucleatum in Colorectal Cancer Cell Proliferation and Migration

The interplay between oral microbiota, gut microbiota and systematic diseases

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