Salivary enzymatic antioxidant activity and dental caries: A cross-sectional study

Vahabzadeh, Zakaria; Hashemi, Zahra Moaven; Nouri, Bijan; Zamani, Fatemeh; Shafiee, Faranak

doi:10.17219/dmp/126179

Cited by 7 publications

(6 citation statements)

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“…The drooling method was often preferred because of its high acceptance rate for unstimulated saliva collection, and was considered as a simple and reproducible method [ 32 ]. In certain studies, the patients were instructed to rinse with water to eliminate any food debris and swallow the remaining saliva prior to the sampling [ 33 – 35 ]. Patients were asked to remain silent, to sit upright on the edge of their chair, keep their mouths open, and tilt their head slightly downward so that saliva could passively drain from the oral cavity and lower lip into a sterile collection device [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

Saliva Collection Methods Among Children and Adolescents: A Scoping Review

Fey,

Bikker,

Hesse

2023

Mol Diagn Ther

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Objective Saliva can be used for screening and diagnostic purposes. Although multiple saliva collection methods are available, their use in children can be limited due to lack of cooperation, developmental stage, and age. The aim of this scoping review was to comprehensively appraise the different methods of saliva collection among both children and adolescents by assessing the available scientific literature. Methods A literature search was performed using the databases PubMed, Embase, and Web of Science. Eligible studies on saliva collection methods among children and adolescents were included for this review. Results The literature search identified 249 eligible articles, of which 205 had a cross-sectional study design. Four distinct saliva collection methods have surfaced: the drooling method, the absorption method, the spitting method, and the suction method. Among infants or children under the age of 6 years, the suction and absorption methods were most preferred. The drooling and spitting methods were only applicable among children above the age of 3 years. When children were not willing to cooperate, the absorption method was most feasible. In adolescents and older children, no specific method was found to be preferred over another method. Conclusion Overall, saliva collection is well tolerated by children and adolescents, with the absorption and suction methods being preferred with young and uncooperative children. Supplementary Information The online version contains supplementary material available at 10.1007/s40291-023-00684-9.

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Section: Resultsmentioning

confidence: 99%

Saliva Collection Methods Among Children and Adolescents: A Scoping Review

Fey,

Bikker,

Hesse

2023

Mol Diagn Ther

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“…Catalase is able to transform H 2 O 2 , produced by SOD, in water and oxygen thanks to the help of manganese or iron, two types of cofactors [ 38 , 40 ]. GPX is capable of transforming H 2 O 2 in water and lipid peroxides [ 41 ]. The oral peroxidase activity is performed by salivary lactoperoxidase (LPO) and myeloperoxidase (MPO).…”

Section: Antioxidants In the Oral Cavitymentioning

confidence: 99%

The Emerging Role of Salivary Oxidative Stress Biomarkers as Prognostic Markers of Periodontitis: New Insights for a Personalized Approach in Dentistry

Viglianisi

Tartaglia

Santonocito

et al. 2023

JPM

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Periodontitis is a multifactorial and infective oral disease that leads to the destruction of periodontal tissues and tooth loss. Although the treatment of periodontitis has improved recently, the effective treatment of periodontitis and the periodontitis-affected periodontal tissues is still a challenge. Therefore, exploring new therapeutic strategies for a personalized approach is urgent. For this reason, the aim of this study is to summarize recent advances and the potential of oxidative stress biomarkers in the early diagnosis and personalized therapeutic approaches in periodontitis. Recently, ROS metabolisms (ROMs) have been studied in the physiopathology of periodontitis. Different studies show that ROS plays a crucial role in periodontitis. In this regard, the reactive oxygen metabolites (ROMs) started to be searched for the measures of the oxidizing capacity of the plasma understood as the total content of oxygen free radicals (ROS). The oxidizing capacity of plasma is a significant indicator of the body’s oxidant state as well as homocysteine (Hcy), sulfur amino acid, which has pro-oxidant effects as it favors the production of superoxide anion. More specifically, the thioredoxin (TRX) and peroxiredoxin (PRX) systems control reactive oxygen species (ROS), such as superoxide and hydroxyl species, to transduce redox signals and change the activities of antioxidant enzymes to remove free radicals. Superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx), among other antioxidant enzymes, change their activity when ROS are produced in order to neutralize free radicals. The TRX system is triggered and transduces redox signals to do this.

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“…Saliva plays an important role in the protection against oxidative stress. The oral cavity and saliva may form the first line of defense against oxidative stress, thereby providing protective effects against microorganisms, toxins, and oxidants [ 54 , 57 , 58 ].…”

Section: Salivary Antioxidant Systemmentioning

confidence: 99%

“…It plays an essential role in neutralizing hydrogen peroxide (H 2 O 2 ) produced through the SOD dismutation process. It is mainly found in mitochondria, and sometimes in the cytosol [ 58 ].…”

Section: Salivary Antioxidant Systemmentioning

confidence: 99%

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Salivary Redox Homeostasis in Human Health and Disease

Čižmárová

Tomečková

Hubková

et al. 2022

IJMS

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Homeostasis is a self-regulatory dynamic process that maintains a stable internal environment in the human body. These regulations are essential for the optimal functioning of enzymes necessary for human health. Homeostasis elucidates disrupted mechanisms leading to the development of various pathological conditions caused by oxidative stress. In our work, we discuss redox homeostasis and salivary antioxidant activity during healthy periods and in periods of disease: dental carries, oral cavity cancer, periodontal diseases, cardiovascular diseases, diabetes mellitus, systemic sclerosis, and pancreatitis. The composition of saliva reflects dynamic changes in the organism, which makes it an excellent tool for determining clinically valuable biomarkers. The oral cavity and saliva may form the first line of defense against oxidative stress. Analysis of salivary antioxidants may be helpful as a diagnostic, prognostic, and therapeutic marker of not only oral, but also systemic health.

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Salivary enzymatic antioxidant activity and dental caries: A cross-sectional study

Cited by 7 publications

References 0 publications

Saliva Collection Methods Among Children and Adolescents: A Scoping Review

Saliva Collection Methods Among Children and Adolescents: A Scoping Review

The Emerging Role of Salivary Oxidative Stress Biomarkers as Prognostic Markers of Periodontitis: New Insights for a Personalized Approach in Dentistry

Salivary Redox Homeostasis in Human Health and Disease

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