2007
DOI: 10.2223/jped.1598
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Salivary cortisol to assess the hypothalamic-pituitary-adrenal axis in healthy children under 3 years old

Abstract: ResumoObjetivo: Estabelecer intervalos de concentrações referenciais de cortisol salivar em crianças saudáveis, nos períodos matutino e vespertino, verificando os fatores de interferência nessa dosagem e a possibilidade de presença de ritmo circadiano. Métodos:Pesquisa observacional controlada, incluindo aleatoriamente 91 crianças com idade de 45 dias a 36 meses, residentes em comunidade de Santo André (SP). Critérios de inclusão: nutridas, saudáveis, sem febre ou uso de corticóide, subdivididas em faixas etár… Show more

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Cited by 22 publications
(30 citation statements)
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“…Inadequate sleep is more common among children living with parents who argue frequently [2] and family conflict has been reported to precede elevated cortisol levels in children [53]. Sleep deprivation in infants is associated with higher cortisol levels the next morning [10]. Caregiver stress in early life has been associated with increased levels of TNF-a in infants [51]; this proinflammatory cytokine is responsible for sleep control [30].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Inadequate sleep is more common among children living with parents who argue frequently [2] and family conflict has been reported to precede elevated cortisol levels in children [53]. Sleep deprivation in infants is associated with higher cortisol levels the next morning [10]. Caregiver stress in early life has been associated with increased levels of TNF-a in infants [51]; this proinflammatory cytokine is responsible for sleep control [30].…”
Section: Discussionmentioning
confidence: 99%
“…Higher morning cortisol and lower growth hormone levels have been observed in sleep-deprived infants and children [10][11][12]. Shorter stature is more common in children with asthma [13].…”
mentioning
confidence: 99%
“…31 As preterm infants do not exhibit diurnal rhythm, sampling can occur anytime. 24,33 Thus, based on previous studies, we decided to use 1.0 mcg kg À1 cosyntropin with cortisol levels before and 40 min after cosyntropin administration. In order to take into account the wide variability of cortisol levels with and without a stimulation test in healthy and sick neonates, we used the percentage change in cortisol levels from baseline as the result of the study for the ROC curve analysis.…”
Section: à2mentioning
confidence: 99%
“…40,41 Recently, Silva et al used this method to assess the HPA axis in Brazilian children aged 45 days to 36 months, establishing reference values that will be useful to studies that investigate adrenal insufficiency in the future. 42 Determination of free cortisol in 24-hour urine is not indicated for assessing lack of HPA axis function since less than 1% of free cortisol is excreted in urine. 28 Therefore, this test is more used to assess hypercortisolism, which is a situation in which transcortin saturation occurs, thereby making increased excretion of free cortisol in urine possible.…”
Section: Relapse Of the Underlying Diseasementioning
confidence: 99%