Frequent nocturnal awakening in early life is associated with nonatopic asthma in children

Kozyrskyj, Anita L.; Kendall, Garth; Zubrick, Stephen R.; Newnham, John P.; Sly, Peter D.

doi:10.1183/09031936.00040509

Cited by 26 publications

(53 citation statements)

References 56 publications

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“…Among studies that examined these conditions, only three detected significant risks, in two, associated with cats and/or dogs during early life [22,40], and in one, with rodents [14]. Frequent waking at night during the first 3 years of life, possibly related to respiratory infections, was associated with non-atopic asthma at ages 6 and 14 years [42]. …”

Section: Resultsmentioning

confidence: 99%

Risk factors for non-atopic asthma/wheeze in children and adolescents: a systematic review

Strina

Barreto

Cooper

et al. 2014

Emerg Themes Epidemiol

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BackgroundThe study of non-atopic asthma/wheeze in children separately from atopic asthma is relatively recent. Studies have focused on single risk factors and had inconsistent findings.ObjectiveTo review evidence on factors associated with non-atopic asthma/wheeze in children and adolescents.MethodsA review of studies of risk factors for non-atopic asthma/wheeze which had a non-asthmatic comparison group, and assessed atopy by skin-prick test or allergen-specific IgE.ResultsStudies of non-atopic asthma/wheeze used a wide diversity of definitions of asthma/wheeze, comparison groups and methods to assess atopy. Among 30 risk factors evaluated in the 43 studies only 3 (family history of asthma/rhinitis/eczema, dampness/mold in the household, and lower respiratory tract infections in childhood) showed consistent associations with non-atopic asthma/wheeze. No or limited period of breastfeeding was less consistently associated with non-atopic asthma/wheeze. The few studies examining the effects of overweight/obesity and psychological/social factors showed consistent associations. We used a novel graphical presentation of different risk factors for non-atopic asthma/wheeze, allowing a more complete perception of the complex pattern of effects.ConclusionsMore research using standardized methodology is needed on the causes of non-atopic asthma.

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Section: Resultsmentioning

confidence: 99%

Risk factors for non-atopic asthma/wheeze in children and adolescents: a systematic review

Strina

Barreto

Cooper

et al. 2014

Emerg Themes Epidemiol

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“…In recent years, an increased prevalence of sleep-related disorders, such as snoring, self-reported apnea, difficulty in inducing and maintaining sleep, and daytime sleepiness in asthmatic subjects has been reported [18,30,42]. In addition, other studies also have reported patients with SDB are more vulnerable to asthma [19,20]. All these studies, together with our cross-sectional study and meta-analysis, support the hypothesis that OSA and habitual snoring are independent risk factors for asthma.…”

Section: Discussionmentioning

confidence: 99%

Sleep-disordered breathing and asthma: evidence from a large multicentric epidemiological study in China

Liu

Jin

et al. 2015

Respir Res

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BackgroundPrevious studies have postulated that sleep-disordered breathing (SDB) may be associated with the occurrence and exacerbation of asthma. However, there was limited quantitative evidence on the topic. This study aimed at investigating the prevalence and predisposing factors of asthma, and quantifying the association between SDB and asthma among school-aged children in China. In addition, a comprehensive meta-analysis of the published evidences and our findings were further conducted.MethodsTo test the hypothesis, we conducted a multicentric cross-sectional study involving 22,478 children aged 5–12 years recruited from eight cities in China. Furthermore, a meta-analysis based on both previously published studies and our cross-sectional study was performed.ResultsThe prevalence rate of SDB and asthma was 12.0% and 3.5% among our cross-sectional study sample. It was demonstrated that symptoms of SDB, such as habitual snoring (OR = 1.28, 95%CI: 1.01-1.62), and obstructive sleep apnea (OSA) (OR = 1.92, 95%CI: 1.34-2.76), were significantly associated with asthma, after adjusting for potential confounding factors. In the meta-analysis, SDB was correlated with the prevalence of asthma in both children (OR = 1.58, 95%CI: 1.35-1.80) and adults (OR = 1.55, 95%CI: 1.42-1.67).ConclusionsOur results provide further evidence for the independent association between SDB and asthma. The clinical significance of our findings lies in the emphasis that children undergoing examination or treatment for asthma should be routinely screened for sleep problems. Further systematic study is required to illuminate the underlying mechanism.

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“…Not enough sleep in infants and children is associated with overweight/obesity and lower cognitive performance [101, 102], and sleep fragmentation increases the risk of asthma [103]. Sleep disorders are commonly comorbid with psychiatric conditions in children and adolescents [104], including attention deficit hyperactivity disorder, anxiety, depression, and autism spectrum disorders [105].…”

Section: What Can Go Wrong? Sleep Disturbances and Developmentmentioning

confidence: 99%

Sleep and Early Cortical Development

Kurth

Olini

Huber

et al. 2015

Curr Sleep Medicine Rep

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Sleep is increasingly recognized as a key process in neurodevelopment. Animal data show that sleep is essential for the maturation of fundamental brain functions, and growing epidemiological findings indicate that children with early sleep disturbance suffer from later cognitive, attentional, and psychosocial problems. Still, major gaps exist in understanding processes underlying links between sleep and neurodevelopment. One challenge is to translate findings from animal research to humans. In this review, we describe parallels and differences in sleep and development of the cortex in humans and animals and discuss emerging questions.

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Frequent nocturnal awakening in early life is associated with nonatopic asthma in children

Cited by 26 publications

References 56 publications

Risk factors for non-atopic asthma/wheeze in children and adolescents: a systematic review

Risk factors for non-atopic asthma/wheeze in children and adolescents: a systematic review

Sleep-disordered breathing and asthma: evidence from a large multicentric epidemiological study in China

Sleep and Early Cortical Development

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