Salivary antibodies to Hellcobacter pylori: screening dyspeptic patients before endoscopy

Patel, Praful; Mendall, Michael A.; Khulusi, S.; Molineaux, N.; Levy, J.; Maxwell, J. D.; Northfield, T. C.

doi:10.1016/s0140-6736(94)91899-6

Cited by 88 publications

(67 citation statements)

References 7 publications

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“…Salivary screening is less accurate than serological testing (sensitivity 0.85, specificity 0.78) 36 but equally costly, so we did not consider it in the model but we present the effectiveness data to reflect the effect of a less accurate serological test.…”

Section: Variation Of Screening Methodsmentioning

confidence: 99%

See 1 more Smart Citation

The cost-effectiveness of screening for Helicobacter pylori to reduce mortality and morbidity from gastric cancer and peptic ulcer disease: a discrete-event simulation model

Roderick

Davies

Raftery

et al. 2003

Health Technol Assess

Self Cite

113

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Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. NHS libraries can subscribe free of charge. Public libraries can subscribe at a very reduced cost of £100 for each volume (normally comprising 30-40 titles). The commercial subscription rate is £300 per volume. Please see our website for details. Subscriptions can only be purchased for the current or forthcoming volume. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK.We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. HTAThe cost-effectiveness of screening for Helicobacter pylori to reduce mortality and morbidity from gastric cancer and peptic ulcer disease: a discrete-event simulation model P Roderick NHS R&D HTA ProgrammeT he NHS R&D Health Technology Assessment (HTA) Programme was set up in 1993 to ensure that high-quality research information on the costs, effectiveness and broader impact of health technologies is produced in the most efficient way for those who use, manage and provide care in the NHS.Initially, six HTA panels (pharmaceuticals, acute sector, primary and community care, diagnostics and imaging, population screening, methodology) helped to set the research priorities for the HTA Programme. However, during the past few years there have been a number of changes in and around NHS R&D, such as the establishment of the National Institute for Clinical Excellence (NICE) and the creation of three new research programmes: Service Delivery and Organisation (SDO); New and Emerging Applications of Technology (NEAT); and the Methodology Programme.This has meant that the HTA panels can now focus more explicitly on health technologies ('health technologies' are broadly defined to include all interventions used to prom...

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Section: Variation Of Screening Methodsmentioning

confidence: 99%

“…Salivary tests and rapid blood tests do not perform as well as the serological one or UBT but might be considered in a screening context. 36,37 Most H. pylori-positive individuals will remain asymptomatic thoroughout life with no symptoms of peptic ulcer disease and will die of causes unrelated to H. pylori. 38 A small proportion will develop gastric cancer.…”

mentioning

confidence: 99%

The cost-effectiveness of screening for Helicobacter pylori to reduce mortality and morbidity from gastric cancer and peptic ulcer disease: a discrete-event simulation model

Roderick

Davies

Raftery

et al. 2003

Health Technol Assess

Self Cite

113

View full text Add to dashboard Cite

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“…Surprisingly, detection of specific IgA to H. pylori could not distinguish between infected or noninfected individuals (324,574), but detection of IgG could (324). Following the princeps study by Patel et al (435), 15 studies have been published (Table 6), six of them using the commercial kit Helisal (Cortecs Diagnostics, Deeside, United Kingdom) for salivary testing and the Oralfluid ELISA (Enteric Products, Stony Brook, NY). Four of the studies were conducted with children.…”

Section: Detection Of H Pylori Antibodiesmentioning

confidence: 99%

Helicobacter pyloriDetection and Antimicrobial Susceptibility Testing

2007

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SUMMARY The discovery of Helicobacter pylori in 1982 was the starting point of a revolution concerning the concepts and management of gastroduodenal diseases. It is now well accepted that the most common stomach disease, peptic ulcer disease, is an infectious disease, and all consensus conferences agree that the causative agent, H. pylori, must be treated with antibiotics. Furthermore, the concept emerged that this bacterium could be the trigger of various malignant diseases of the stomach, and it is now a model for chronic bacterial infections causing cancer. Most of the many different techniques involved in diagnosis of H. pylori infection are performed in clinical microbiology laboratories. The aim of this article is to review the current status of these methods and their application, highlighting the important progress which has been made in the past decade. Both invasive and noninvasive techniques will be reviewed.

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“…14,15 However, it has the disadvantage of stool samples being difficult to collect. Previous studies have shown that H pylori-specific IgG antibodies can also be detected in saliva 16,17 and urine, 18,19 suggesting a possibility of easy-to-use diagnostic tools. However, the salivary test has been shown to have poor sensitivity and specificity.…”

Section: G Astric Infection Withmentioning

confidence: 96%

Urine-Based Enzyme-Linked Immunosorbent Assay for the Detection of Helicobacter pylori Infection in Children

et al. 2001

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ABSTRACT. Objective. Serology and 13 C-urea breath test have been widely used as noninvasive tests to detect Helicobacter pylori infection. However, easier collection of samples and lower costs are desirable for diagnosis of the individual patient or for use in epidemiologic studies. Our aim was to study the diagnostic accuracy of a recently developed urine-based enzyme-linked immunosorbent assay (ELISA) kit for the detection of H pylorispecific immunoglobulin G (IgG) antibodies in children.Study Design. Specimens of serum and randomly voided urine were collected from 816 children (0 -15 years old) and were analyzed using 2 serum-based ELISA kits and a urine-based ELISA kit, respectively. Based on results of serology, the sensitivity, specificity, and accuracy of the urine-based ELISA kit were evaluated. With regard to false-positive and false-negative results, urinary IgG concentrations and IgG/creatinine levels were studied.Results. Both serum-based ELISAs were positive in 41 children and were negative in 666, who were enrolled in this study. The remaining 109 children were excluded because of disagreement between the results of the 2 serum-based ELISAs, including indeterminate values. Overall sensitivity, specificity, and accuracy of urinebased ELISA test compared with serology were 85.4%, 95.5%, and 94.9%, respectively. On positivity rates, the urine-based ELISA was closely coincident with the serum-based ELISA in each age group. There was no correlation between antibody levels detected by urine-based ELISA and each serum-based ELISA. Urinary IgG concentrations and IgG/creatinine levels were significantly higher in false-positives and were lower in false-negatives than in true-positives plus true-negatives for serology. Most of those with false-positive results had trace to moderate proteinuria.Conclusions. The urine-based ELISA is an alternative to serum-based ELISA for diagnosis of H pylori infection in children and should be suitable for large-scale epidemiologic studies concerning the organism. In children with proteinuria, results of the test should be interpreted with caution. It is possible that the urine-based ELISA method would be applicable to diagnosis of other infectious diseases. Pediatrics 2001;107(6). URL: http://www. pediatrics.org/cgi/content/full/107/6/e87; enzyme-linked immunosorbent assay, Helicobacter pylori, immunoglobulin G, urine.

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Salivary antibodies to Hellcobacter pylori: screening dyspeptic patients before endoscopy

Cited by 88 publications

References 7 publications

The cost-effectiveness of screening for Helicobacter pylori to reduce mortality and morbidity from gastric cancer and peptic ulcer disease: a discrete-event simulation model

The cost-effectiveness of screening for Helicobacter pylori to reduce mortality and morbidity from gastric cancer and peptic ulcer disease: a discrete-event simulation model

Helicobacter pyloriDetection and Antimicrobial Susceptibility Testing

Urine-Based Enzyme-Linked Immunosorbent Assay for the Detection of Helicobacter pylori Infection in Children

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