Saliva and Gingival Crevicular Fluid: Contributions to Mucosal Defense

Saloom, Hayder F.; Carpenter, Guy

doi:10.1007/978-3-319-56065-6_7

Cited by 2 publications

(2 citation statements)

References 99 publications

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“…Along with the macroorganism, the latter consists of a collection of numerous microbiocenoses with a specific composition that inhabit a particular biotope (niche) within the host body. The microbiome is a collection of human microorganisms that cohabit normally and pathologically with it, taking part in physiological and pathophysiological processes, as well as drug and hormone metabolism [10,11]. It may be concluded that one of the most promising fields of medical research is the investigation of a group of genes involved in the creation of microbiota in diverse localizations, including the gastrointestinal tract, skin, and mucous membranes of the sexual organs.…”

Section: Introductionmentioning

confidence: 99%

Immunological parameters examination of the oral fluid in normal and pathological conditions: sensitivity analysis of microorganisms in modern therapeutic practice in vitro

Sabah¹,

Nataliya²

2021

International Journal of Computational and Experimental Science and Engineering

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Inflammation of the mucosal immune system is a common occurrence (saliva). The masticatory process and salivary enzymes destroy antigenic material that enters the mouth cavity, yet it can still activate immunological responses. Many soluble components are secreted by epithelial cells or incorporated into oral cavity fluids. Defensins, histatins, lysozyme, and lactoferrin all have antibacterial action. They appear to work synergistically with secretory IgA. The objectives of this study is to examine the immunological parameters (concentration of total IgA and secretory IgA) of the oral fluid of the examined individuals in normal and pathological conditions; and to identify the sensitivity/resistance of microorganisms-the main representatives of the oral microflora to antimicrobial drugs widely used in modern therapeutic practice (antibiotics) in vitro. To measure secretory IgA in oral fluid, we used a solid-phase immunoassay and a ZAO Vector Best sIgA ELISA BEST strip. The "secretory IgA-ELISA" reagent collection is designed to quantify secretory IgA in body fluids using enzyme-linked immunosorbent assay. The enzyme-linked immunosorbent assay measures secretory IgA. The t-test was used to assess the significance of differences across indicator groups. Results indicated that amount of total IgA in oral fluid is significantly lower in people with dental and periodontal problems than in people who are healthy. This indicates a decrease in oral cavity resistance and an increase in carious/periodontal processes. Caries and/or periodontal disease have been linked to lgA deficiency. The results showed that staphylococci and streptococci dominated the oral cavity microbiota in the comparison groups. In addition to this, Neisseria and Veillonella were found. Streptococci accounted for 57 percent of all microorganisms planted in this biotope. Enterobacteria accounted for up to 15%, whereas Neisseria accounted for about 4% and 2%. The decrease in sIgA levels in periodontitis patients' saliva indicates a lack of local mucous membrane protection, increasing the risk of caries and periodontitis. The lower sIgA levels in the mouth make tooth tissue more susceptible to caries-causing microbe adherence than in healthy people.

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Section: Introductionmentioning

confidence: 99%

Immunological parameters examination of the oral fluid in normal and pathological conditions: sensitivity analysis of microorganisms in modern therapeutic practice in vitro

Sabah¹,

Nataliya²

2021

International Journal of Computational and Experimental Science and Engineering

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“…It is considered the first line of defense of the host against pathogens that colonize or invade mucosal surfaces and have been studied as potential diagnostic tests for periodontal disease. (1,2) The aim of this study was to investigate the correlation between periodontitis and smoking status and secretory IgA level among a sample of Egyptian patients.…”

Section: Introductionmentioning

confidence: 99%

Correlation between smoking status, periodontitis and SIgA level in a sample of patients

Sallam

Kazem

2019

Egyptian Dental Journal

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Periodontitis is one of the most highly prevalent chronic diseases worldwide. Periodontal disease, along with severe dental caries, causes tooth loss, which result in reduced functional capacity, selfesteem and social relationships. Hence, it affects people's quality of life .Periodontitis is associated with several risk factors among which, is tobacco smoking. (3) Throughout the years, studies has recorded delirious effect of smoking on periodontal tissues. However, there were different selected populations and /or different methodologies among these studies. In addition, the precise mechanism by which tobacco influences periodontal destruction and its related alteration still need complementary investigation (4,5,6) . It has been observed that smoking can alter salivary fluid, salivary enzymes. Yet, only a few studies has recorded the effect of tobacco smoking on salivary immunoglobulin (7,8)

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Saliva and Gingival Crevicular Fluid: Contributions to Mucosal Defense

Cited by 2 publications

References 99 publications

Immunological parameters examination of the oral fluid in normal and pathological conditions: sensitivity analysis of microorganisms in modern therapeutic practice in vitro

Immunological parameters examination of the oral fluid in normal and pathological conditions: sensitivity analysis of microorganisms in modern therapeutic practice in vitro

Correlation between smoking status, periodontitis and SIgA level in a sample of patients

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