Safety, tolerability and pharmacokinetics of liposomal curcumin in healthy humans

Storka, Angela; Vcelar, Brigitta; Klickovic, Uros; Gouya, Ghazaleh; Weisshaar, Stefan; Aschauer, Stefan; Bolger, Gordon T.; Helson, Lawrence; Wolzt, Michael

doi:10.5414/cp202076

Cited by 117 publications

(94 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In spite of these properties, the wide use of Curcumin has been limited mainly by its poor water solubility and consequently its poor bioavailability. Intravenous administration of Curcumin, which is a small fat-soluble molecule, is inconvenient and unsafe; moreover, the disadvantages of Curcumin includes its low bioavailability, short half-life, and difficulty in reaching and maintaining therapeutic concentration after entering the body [19]. Large-dose administration not only fails to significantly increase the in vivo concentration of Curcumin but also induces oxidative stress, generating concentration-dependent toxicity [20].…”

Section: Discussionmentioning

confidence: 99%

Curcumin-carrying nanoparticles prevent ischemia-reperfusion injury in human renal cells

Jiang

et al. 2016

Oncotarget

View full text Add to dashboard Cite

Renal ischemia-reperfusion injury (IRI) is a major complication in clinical practice. However, despite its frequency, effective preventive/treatment strategies for this condition are scarce. Curcumin possesses antioxidant properties and is a promising potential protective agent against renal IRI, but its poor water solubility restricts its application. In this study, we constructed curcumin-carrying distearoylphosphatidylethanolamine-polyethylene glycol nanoparticles (Cur-NPs), and their effect on HK-2 cells exposed to IRI was examined in vitro. Curcumin encapsulated in NPs demonstrated improved water solubility and slowed release. Compared with the IRI and Curcumin groups, Cur-NP groups displayed significantly improved cell viability, downregulated protein expression levels of caspase-3 and Bax, upregulated expression of Bcl-2 protein, increased antioxidant superoxide dismutase level, and reduced apoptotic rate, reactive oxygen species level, and malondialdehyde content. Results clearly showed that Cur-NPs demonstrated good water solubility and slow release, as well as exerted protective effects against oxidative stress in cultured HK-2 cells exposed to IRI.

show abstract

Section: Discussionmentioning

confidence: 99%

Curcumin-carrying nanoparticles prevent ischemia-reperfusion injury in human renal cells

Jiang

et al. 2016

Oncotarget

View full text Add to dashboard Cite

show abstract

“…Storka et al indicated that shortterm intravenous dosing of liposomal curcumin appeared to be safe and had laid the foundation for the clinical application of curcumin (36). A randomized controlled trial conducted by Lang demonstrated that curcumin was a safe and promising agent for the treatment of ulcerative colitis (37).…”

Section: Discussionmentioning

confidence: 98%

The Protective Role of Curcumin in Zymosan-Induced Multiple Organ Dysfunction Syndrome in Mice

Liu

Zhang²,

Pang³

et al. 2016

Shock

View full text Add to dashboard Cite

show abstract

“…Recently, a phase I dose-escalation study showed that participants receiving single dose liposomal curcumin (10-400 mg/m 2 ) had a dose dependent increase in both the plasma concentration of curcumin and its active metabolite tetrahydrocurcumin (THC) without clinical side effects. Red blood cell morphology changes were seen at curcumin doses greater than 120 mg/m 2 , possibly indicating a dose limiting sign of toxicity [37]. Additionally, liquid micellar curcumin formulations have shown to have significant bioavailability without increased toxicities.…”

Section: Curcuminmentioning

confidence: 99%

Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence

2016

View full text Add to dashboard Cite

Cancer chemoprevention involves the use of different natural or biologic agents to inhibit or reverse tumor growth. Epidemiological and pre-clinical data suggest that various natural phytochemicals and dietary compounds possess chemopreventive properties, and in-vitro and animal studies support that these compounds may modulate signaling pathways involved in cell proliferation and apoptosis in transformed cells, enhance the host immune system and sensitize malignant cells to cytotoxic agents. Despite promising results from experimental studies, only a limited number of these compounds have been tested in clinical trials and have shown variable results. In this review, we summarize the data regarding select phytochemicals including curcumin, resveratrol, lycopene, folates and tea polyphenols with emphasis on the clinical evidence supporting the efficacy of these compounds in high-risk populations.

show abstract

Safety, tolerability and pharmacokinetics of liposomal curcumin in healthy humans

Abstract: Short-term intravenous dosing of liposomal curcumin appears to be safe up to a dose of 120 mg/m2. Changes in red blood cell morphology may represent a dose limiting sign of toxicity.

Cited by 117 publications

References 21 publications

Curcumin-carrying nanoparticles prevent ischemia-reperfusion injury in human renal cells

Curcumin-carrying nanoparticles prevent ischemia-reperfusion injury in human renal cells

The Protective Role of Curcumin in Zymosan-Induced Multiple Organ Dysfunction Syndrome in Mice

Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence

Contact Info

Product

Resources

About