Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence

Kotecha, Ritesh; Takami, Akiyoshi; Espinoza, J. Luis

doi:10.18632/oncotarget.9593

Cited by 322 publications

(240 citation statements)

References 126 publications

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“…However, the overall treatment efficiency for malignant and metastatic breast cancer remains stagnant. Recent studies have identified effective phytochemicals for the treatment of cancer, including advanced stage breast cancer (26)(27)(28). Therefore, the potential of morusin as a therapeutic agent for breast cancer was evaluated in the present study.…”

Section: Discussionmentioning

confidence: 99%

Morusin induces apoptosis by regulating expression of Bax and Survivin in human breast cancer cells

Kang

Kim

et al. 2017

Oncology Letters

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Abstract. Morusin which has been isolated from the root bark of Morus alba L. (Moraceae) has previously demonstrated anticancer activity in various types of cancer cells such as hepatocellular carcinoma, glioma and prostate cancer. However, the effect of morusin on breast cancer cells remains unclear. In the present study, the potential of morusin as an anti-cancer agent in breast cancer was investigated. The results of the present study revealed that the treatment of morusin induced cell death in various human breast cancer cell lines, but exhibited little effect on normal human breast epithelial cells. In Annexin V-propidium iodide double staining assays, morusin significantly increased apoptosis in a dose-dependent manner in human breast cancer cells. The apoptosis marker proteins cleaved caspase 3 and 9 were consistently upregulated following treatment of cells with morusin in a time-and dose-dependent manner. Furthermore, morusin was demonstrated to modulate the expression of the anti-apoptotic protein Survivin and pro-apoptotic protein B-cell lymphoma 2-associated-x protein (Bax) in human breast cancer cells. These results indicate that morusin induces apoptosis by suppressing Survivin and inducing Bax proteins, suggesting that morusin is a potentially effective therapeutic agent for the treatment of patients with breast cancer.

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Section: Discussionmentioning

confidence: 99%

Morusin induces apoptosis by regulating expression of Bax and Survivin in human breast cancer cells

Kang

Kim

et al. 2017

Oncology Letters

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“…Chemoprevention is the administration of natural products or synthetic compounds to inhibit tumorigenesis, trigger apoptosis, or both, in tumor cells (1). However, natural chemopreventive agents, which include polyphenols, alkaloids, carotenoids, and nitrogen compounds, have little or no toxicity in normal cells (1).…”

Section: Introductionmentioning

confidence: 99%

“…However, natural chemopreventive agents, which include polyphenols, alkaloids, carotenoids, and nitrogen compounds, have little or no toxicity in normal cells (1). Flavonoids are compounds isolated from a wide range of dietary foods, including vegetables, fruit, wine and tea, and have received a attention due to their chemopreventive and chemotherapeutic activities (2).…”

Section: Introductionmentioning

confidence: 99%

Naringenin inhibits migration of lung cancer cells via the inhibition of matrix metalloproteinases-2 and −9

Chang

Lai

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Lung cancer is among the most common causes of cancer-related mortality. It has a high mortality rate and resistance to chemotherapy due to its high metastatic potential. Naringenin, a bioactive compound identified in several fruits, displays anti-inflammatory and antitumor effects. Furthermore, naringenin mitigates the migration of several human cancer cell types. However, the effects of naringenin on lung cancer remain unclear. The current study investigated the mechanisms of naringenin on the migration of lung cancer A549 cells. The results indicate that significant alteration in A549 cell proliferation was observed in response to naringenin (0-300 µM) treatment for 24 and 48 h. Furthermore, a dose-dependent migration inhibition of A549 in the presence of naringenin was observed by healing and transwell migration assays. In addition, a zymography assay revealed that naringenin exhibited a concentration-dependent inhibition of matrix metalloproteinase (MMP)-2 and -9 activities. Furthermore, naringenin also inhibited the activities of AKT in a dose-dependent manner. These observations indicated that naringenin inhibited the migration of lung cancer A549 cells through several mechanisms, including the inhibition of AKT activities and reduction of MMP-2 and -9 activities.

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“…Phytochemical agents constitute a heterogeneous set of bioactive compounds including alkaloids, polyphenols, carotenoids, and nitrogen compounds. These compounds are naturally found in vegetables, fruits, grains and other plant products and are generally responsible for several plant features such as: smell and color pigmentation (1). For a long time, the medicinal plants have been traditionally used to treat human disorders (2) and about 70 % of antitumoral drugs are natural products or their derivatives (3,4).…”

Section: Introductionmentioning

confidence: 99%

The detection of curcumins’ antitumoral effects via argyrophilic nucleolar organizing region-associated protein synthesis in mice with ehrlich’s ascitic carcinoma

Nisari¹,

Yılmaz²,

Eröz³

et al. 2017

BLL

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BACKGROUND: Curcumin is a polyphenol compound that has antioxidant, anticancer, anti-infl ammatory, antihyperlipidemic and antimicrobial effects. Nucleolar-organizing regions are the sites of the gene on chromosomes. The present study was aimed to show the antitumoral effect of curcumin via AgNOR protein synthesis in Ehrlich's ascitic carcinoma (EAC) bearing mice. METHODS: Twenty three mice with EAC were randomly divided into 3 groups as positive control (n = 7), group 2 (n = 8) and 3 (n = 8) treated intraperitoneally with curcumin (25 mg/kg) and (50 mg/kg), respectively. The animals were sacrifi ced on Day 16, the solid tumors were removed out. Then, total AgNOR area/nuclear area (TAA/NA) and the mean AgNOR number were estimated for each mice. RESULT: Statistically signifi cant differences were determined among the whole groups for TAA/NA ratio (p = 0.000), conversely mean AgNOR number (p = 0.361). When comparingthe two groups; while no difference was determined between the control and curcumin (25 mg/kg) groups (p = 0.061), the signifi cant differences were detected between the control and curcumin (50 mg/kg) groups (p = 0.000) and between curcumin (25 mg/kg) and curcumin (50 mg/kg) groups (p = 0.000) for TAA/NA ratio. However, there was no signifi cant difference for the mean AgNOR number in double comparison of the groups. CONCLUSIONS: The current study showed that curcumin had a crucial function against cancer development. Also, both AgNOR values might be used as biomarkers for detection of the most reliable therapeutic dose selection of cancer treatment (Tab. 3, Fig. 2, Ref. 27). Text in PDF www.elis.sk.

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Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence

Cited by 322 publications

References 126 publications

Morusin induces apoptosis by regulating expression of Bax and Survivin in human breast cancer cells

Morusin induces apoptosis by regulating expression of Bax and Survivin in human breast cancer cells

Naringenin inhibits migration of lung cancer cells via the inhibition of matrix metalloproteinases-2 and −9

The detection of curcumins’ antitumoral effects via argyrophilic nucleolar organizing region-associated protein synthesis in mice with ehrlich’s ascitic carcinoma

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