Naringenin inhibits migration of lung cancer cells via the inhibition of matrix metalloproteinases-2 and −9

Chang, Huai‐Lu; Chang, Yuh‐Ming; Lai, Shih‐Chan; Chen, Kemin; Wang, Kuan‐Chu; Chiu, Tsu‐Ting; Chang, Fu‐Hsin; Hsu, Li‐Sung

doi:10.3892/etm.2016.3994

Cited by 82 publications

(52 citation statements)

References 26 publications

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“…Desmethylanhydroicaritin from Sophora flavescens exhibited antimigration of U87MG cells by inhibition of MMP‐2 and MMP‐9 activities and protein expression . Naringenin also has been shown to suppress migration via downregulation of MMPs expression in bladder and lung cancer . In line with these observations, treatment with naringenin significantly decreased the activities and expression of MMP‐2 and‐9 in a dose‐dependent manner.…”

Section: Discussionmentioning

confidence: 52%

“…In addition, naringenin blocked TGF‐1/SMAD3 downstream signals, reduced mesenchymal makers' expression, and attenuated MMP‐2 and MMP‐9 activities, and consequently suppressed migration and invasion in pancreatic cancer cells . Recent reports also indicated that naringenin decreased AKT and MMP‐2 activities and inhibited migration in bladder cancer and lung cancer cells …”

Section: Introductionmentioning

confidence: 98%

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Naringenin inhibited migration and invasion of glioblastoma cells through multiple mechanisms

Chen

Chang

Wang

et al. 2018

Environmental Toxicology

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Glioblastoma (GBM) is the most mortality brain cancer in the world. Due to high invasion and drug resistance cause the poor prognosis of GBM. Naringenin, an ingredient of citrus, exhibits many cellular functions such as antioxidant, anti-inflammation, and anticancer. Naringenin inhibits the migration of bladder and lung cancer via modulation of MMP-2 and/or MMP-9 activities, Naringenin inhibits migration and trigger apoptosis in gastric cancer cells through downregulation of AKT pathway. However, the effects of naringenin in GBM still remain to be elucidated. In this study, we reveal the molecular mechanisms of naringenin in the inhibition of migration and invasion in GBM. No overt alternation of cell proliferation was found in of GBM 8901 cells treated with different concentration of naringenin.Slight decreased cell viability was found in GBM 8401 cell treated with 200 and 300 μM naringenin.Significant reduction of migration and invasion as assayed by Boyden chamber analysis was found in of GBM cells treated with 100, 200, and 300 μM naringenin. Zymography analysis also revealed that the activities of MMP-2 and MMP-9 of GBM cells were significantly inhibited in response to 100, 200, or 300 μM naringenin treatment. Proteins of MMP-2 and MMP-9 were downregulated in naringenin treated GBM cells. In addition, naringenin also attenuated the activities of ERK and p38.Naringenin decreased mesenchymal markers (snail and slug) expression as revealed by Western blot analysis. Taken together, our findings indicated that naringenin eliminated the migration and invasion of GBM cells through multiple mechanisms including inhibition of MMPs, ERK, and p38 activities and modulation of EMT markers. Our results also suggested that naringenin may be a potential agent to prevent metastasis of GBM.

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Section: Discussionmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 98%

Naringenin inhibited migration and invasion of glioblastoma cells through multiple mechanisms

Chen

Chang

Wang

et al. 2018

Environmental Toxicology

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“…reported the ability of naringenin to modulate the inflammatory responses triggered by Chlamydia trachomatis in mouse macrophages. Chang et al . reported the role of naringenin as an inhibitor of human lung cancer cell migration.…”

Section: Resultsmentioning

confidence: 99%

“…ketchup, juice, sauces, paste, puree) . Furthermore, tomato fruit can be regarded as a functional food because of its content of antioxidant substances, such as ascorbic acid, lycopene and phenols, thus playing a protective role in humans against cancer as well as chronic diseases …”

Section: Introductionmentioning

confidence: 99%

Yield parameters and antioxidant compounds of tomato fruit: the role of plant defence inducers with or without Cucumber mosaic virus infection

et al. 2019

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BACKGROUND: The production of fruit and vegetables rich in health-promoting components in an eco-friendly context represents the winning answer to the world population demand for food. In this study, the effects of different treatments on the yield and fruit chemical characteristics of tomato (Solanum lycopersicum L.) are reported. The treatments included three inducers of plant defence responses (chitosan, Trichoderma harzianum T-22 and Bacillus subtilis QST713) applied alone or before Cucumber mosaic virus infection. Fruit production and antioxidant compounds were investigated by ultrahigh-performance liquid chromatography (UHPLC) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). RESULTS: Compared to control fruit harvested from untreated and healthy plants, treatment with QST713 increased the fruit number. Furthermore, plant treatments with T22, QST713 and chitosan alone enhanced fruit carotenoids (lutein and -carotene), ascorbic acid and phenolic acids (caffeoyl glucoside and p-coumaroyl glucoside). In parallel, compared to fruit harvested from only CMV-infected plants, treatments with T22, QST713 and chitosan before CMV enhanced fruit ascorbic acid and flavonoids (quercetin 3-O-xylosyl-rutinoside and rutin). CONCLUSION: Antioxidant compounds of tomato fruit can increase with the application of the plant defence inducers, thus protecting both the consumer and plant health. Statistical data analysisData normal distribution was tested using the Shapiro-Wilk test (P ≤ 0.05) and homoscedasticity using Bartlett's test (P ≤ 0.05). Data were analysed by one-way analysis of variance (ANOVA), parametric and non-parametric, performing Tukey's HSD and Kruskal-Wallis test, respectively. Statistical data analyses were carried out using RStudio software, version 1.0.136 (Integrated Development for R; Boston, MA, USA).J Sci Food Agric 2019; 99: 5541-5549

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“…prostate and oral cancer (Tu et al, 2016;Han et al, 2018b) Naringenin anti-proliferation CCND1, EREG, ESR2, MAPK1/14 cervical, colon, colorectal cancer, and hepatocarcinoma (Totta et al, 2004;Song et al, 2015;Zhang et al, 2016) Targets Cancer types Ref inhibiting metastasis AKT1, CDH1, MAPK1/4, MMP2/9, NCL, NFKB, PKCZ, PKCE, RAC1, RHO, RHOA, SCN9A, SNAIL1/2, TGFB1, TWIST1, VIM breast, lung, and bladder cancer (Liao et al, 2014;Zhang et al, 2016;Chang et al, 2017;Aktas and Akgun, 2018;Han et al, 2018c;Zhao et al, 2019b) promoting apoptosis AKT1, MAP3K5, ATF3, BAX, BCL2, BIRC5, CASP3/9, JNK, MAPK1/3/14, TP53, RPS6KB1, ROS1, RPS6…”

Section: Discussionmentioning

confidence: 99%

Mapping Pharmacological Network of Multi-Targeting Litchi Ingredients in Cancer Therapeutics

Cao

Han

et al. 2020

Front. Pharmacol.

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Considerable pharmacological studies have demonstrated that the extracts and ingredients from different parts (seeds, peels, pulps, and flowers) of Litchi exhibited anticancer effects by affecting the proliferation, apoptosis, autophagy, metastasis, chemotherapy and radiotherapy sensitivity, stemness, metabolism, angiogenesis, and immunity via multiple targeting. However, there is no systematical analysis on the interaction network of "multiple ingredients-multiple targets-multiple pathways" anticancer effects of Litchi. In this study, we summarized the confirmed anticancer ingredients and molecular targets of Litchi based on published articles and applied network pharmacology approach to explore the complex mechanisms underlying these effects from a perspective of system biology. The top ingredients, top targets, and top pathways of each anticancer function were identified using network pharmacology approach. Further intersecting analyses showed that Epigallocatechin gallate (EGCG), Gallic acid, Kaempferol, Luteolin, and Betulinic acid were the top ingredients which might be the key ingredients exerting anticancer function of Litchi, while BAX, BCL2, CASP3, and AKT1 were the top targets which might be the main targets underling the anticancer mechanisms of these top ingredients. These results provided references for further understanding and exploration of Litchi as therapeutics in cancer as well as the application of "Component Formula" based on Litchi's effective ingredients.

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Naringenin inhibits migration of lung cancer cells via the inhibition of matrix metalloproteinases-2 and −9

Cited by 82 publications

References 26 publications

Naringenin inhibited migration and invasion of glioblastoma cells through multiple mechanisms

Naringenin inhibited migration and invasion of glioblastoma cells through multiple mechanisms

Yield parameters and antioxidant compounds of tomato fruit: the role of plant defence inducers with or without Cucumber mosaic virus infection

Mapping Pharmacological Network of Multi-Targeting Litchi Ingredients in Cancer Therapeutics

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