Safety of Medium-Chain Triglycerides Used as an Intraocular Tamponading Agent in an Experimental Vitrectomy Model Rabbit

Auriol, S; Mahieu, L.; Brousset, Pierre; Malecaze, F; Mathis, V.

doi:10.1097/iae.0b013e3182618d2e

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…In the form of an oil‐in‐water emulsion, MCTs have the potential to be used as drug carriers for sustained release of dexamethasone palmitate in vitreous cavity (Daull et al 2013). Furthermore, with physical properties similar to conventional SO, MCTs present great potential to be alternatives of SO as an intraocular tamponade agents in animal studies with no obvious retinal toxicity (Auriol et al 2013; Soler et al 2017).…”

Section: Novel Alternatives To So In Vitreoretinal Surgerymentioning

confidence: 99%

Silicone oil in vitreoretinal surgery: indications, complications, new developments and alternative long‐term tamponade agents

Chen

Kearns

Zhou

et al. 2020

Acta Ophthalmologica

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Silicone oil (SO) has been used as a long-term tamponade agent in the treatment of complicated vitreoretinal diseases for about half a century, during which time many advances in surgical techniques and technologies have been made. This review summarizes the chemical and physical properties of SO, its indications and complications, including particularly emulsification. The mechanisms and risk factors for emulsification are discussed, as well as novel strategies for its effective removal. Finally, the review focuses on new improved formulations of SO, including research into slow-release pharmacological agents within SO and provides an overview of alternatives to SO for the purpose of long-term tamponade that are being developed.

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Section: Novel Alternatives To So In Vitreoretinal Surgerymentioning

confidence: 99%

Silicone oil in vitreoretinal surgery: indications, complications, new developments and alternative long‐term tamponade agents

Chen

Kearns

Zhou

et al. 2020

Acta Ophthalmologica

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“…Medium-chain triglycerides. Soler et al 81 and Auriol et al 82 reported the use of medium-chain triglycerides (MCTs) as a vitreous substitute.…”

Section: Pva-based Hydrogelmentioning

confidence: 99%

“…However, in vivo study showed that the MCT causes some emulsification and cataract formation in rabbit eyes. Auriol et al 82 performed in vivo study of the MCTs in minipigs and observed that in some of the cases, retinal detachment was not repaired even after 45 days. So, additional study must be needed for checking its potential as vitreous substitute.…”

Section: Pva-based Hydrogelmentioning

confidence: 99%

Vitreous substitutes: An overview of the properties, importance, and development

et al. 2020

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Vitreous or vitreous humor is a complex transparent gel that fills the space between the lens and retina of an eye and acts as a transparent medium that allows light to pass through it to reach the photoreceptor layer (retina) of the eye. The vitreous humor is removed in ocular surgery (vitrectomy) for pathologies like retinal detachment, macular hole, diabetes-related vitreous hemorrhage detachment, and ocular trauma. Since the vitreous is not actively regenerated or replenished, there is a needfor a vitreous substitute to fill the vitreous cavity to provide a temporary or permanent tamponade to the retina following some vitreoretinal surgeries. An ideal vitreous substitute could probably be left inside the eye forever. The vitreous humor is transparent, biocompatible, viscoelastic and highly hydrophilic; polymeric hydrogels with these properties can be a potential candidate to be used as vitreous substitutes.To meet the tremendous demand for the vitreous substitute, many scientists all over the world have developed various kinds of vitreous substitutes or tamponade agent.Vitreous substitutes, whatsoever developed till date, are associated with several advantages and disadvantages, and there is no ideal vitreous substitute available till date. This review highlights the polymer-based vitreous substitutes developed so far, along with their advantages and limitations. The gas-based and oil-based substitutes have also been discussed but very briefly.

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Preliminary study of the safety and efficacy of medium-chain triglycerides for use as an intraocular tamponading agent in minipigs

Soler

Laurent

Sakr

et al. 2017

Graefes Arch Clin Exp Ophthalmol

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Safety of Medium-Chain Triglycerides Used as an Intraocular Tamponading Agent in an Experimental Vitrectomy Model Rabbit

Abstract: Medium-chain triglycerides did not induce morphologic evidence of retinal toxicity. The results suggest that medium-chain triglycerides could be a promising alternative intraocular tamponading agent for the treatment of retinal detachments.

Cited by 5 publications

References 30 publications

Silicone oil in vitreoretinal surgery: indications, complications, new developments and alternative long‐term tamponade agents

Silicone oil in vitreoretinal surgery: indications, complications, new developments and alternative long‐term tamponade agents

Vitreous substitutes: An overview of the properties, importance, and development

Preliminary study of the safety and efficacy of medium-chain triglycerides for use as an intraocular tamponading agent in minipigs

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