Safety evaluation of Trikatu, a generic Ayurvedic medicine in Charles Foster rats

Abstract

-Chemical characterization and acute and sub-acute toxicity study of Trikatu, a generic herbal formulation of Indian system of medicine, was carried out in Charles Foster (CF) rats for safety by the experimental animals (both male and female) and no changes were observed in mortality, morbidity, gross pathology, gain in weight, vital organ weight, hematological (total white blood cells (WBC) and red blood cells (RBC) count), biochemical parameters such as serum creatinine, serum glutamate oxaloa--sue biochemical parameters such as reduced glutathione and malonaldehyde content as oxidative stress markers. In sub-acute experiment, Trikatu was administered at 5, 50 and 300 mg/kg body weight once -300 mg/kg body weight, increase in SGPT activity at 50 mg/kg body weight and decrease in WBC count at 300 mg/kg body weight on 28 th day post treatment.

Antiplasmodial activity of artecyclopentyl mether a new artemisinin derivative and its effect on pathogenesis in Plasmodium yoelii nigeriensis infected mice

“…Lipid peroxidation (LPO) assay was performed to access the vulnerability of the membrane to damage by quantifying the malonaldehyde production as previously described (Chanda et al 2009) from brain.…”

Antitumour and Acute Toxicity Studies of 4-(pyridin-4-yl)-6-(thiophen-2-yl)pyrimidin-2(1<em>H</em>)-one Against Ehrlich Ascites Carcinoma and Sarcoma-180

“…The animals were sacrificed and were subjected to thorough necropsy inspection of the exterior of the whole body and vital organs [37,38].…”

Preparation and evaluation of dispersible tablets of Trikatu extract

“…[1][2][3] It is prepared by mixing dried powder of three fruits, that is, black pepper (Piper nigrum Linn), long pepper (Piper longum Linn) and rhizomes of ginger (Zingiber officinalis Rosc) in the ratio of (1:1:1; w/w). [4] Trikatu has remained one of the oldest and popular Ayurvedic preparation, official in Ayurvedic formulary of India and out of 370 compound formulations listed in the Handbook of Domestic Medicines and Common Ayurvedic Remedies 210 contain either Trikatu or its individual ingredients. [5] Due to its significant traditional acceptance and use, it has remained one of the most popular herbal formulations in Ayurveda.…”