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Study was conducted to evaluate the antioxidative activity of methanolic (ME), ethanolic (EE) and butanolic extracts (BE) of selected gourd vegetables. The antioxidant activity was investigated using different assays namely ferric thiocyanate test (FTC), thiobarbituric acid test (TBA), ferric reducing antioxidant power (FRAP) and DPPH free radicals scavenging test. A densitometric HPTLC analysis was performed for the analysis of phenolic acids and flavonoids. Different extracts of the selected gourd vegetables revealed different antioxidant activity. Different extracts of Lagenaria siceraria, Momordica charantia and Luffa cylindrica revealed significantly higher (p < 0.05) concentrations of total phenols, flavonids, tannins and carotenoids content and also the antioxidant activity in comparison to remaining vegetable extracts. Correlation studies indicated that FRAP test best described the antioxidant activity of phenols, flavonoids and carotenoids (r = 0.854, 0.692 and 0.915 respectively). HPTLC profiles revealed the presence of maximum number of phenolic acids and flavonoids in L. siceraria and M. charantia.

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Context: Boswellic acids (BAs) are isolated from oleo gum of Boswellia serrata and are mainly used as potential anti-inflammatory, hypolipidemic, immunomodulatory, and antitumor agents. Pharmacokinetic investigations of BAs uncover its poor bioavailability through digestive system thus creates a need for improved therapeutic responses which can possibly be achieved by developing formulations through novel delivery system. Objective: Present study was conducted to design topical BA-loaded proniosomal gel for the management of inflammatory disorders with enhanced bioavailability. Materials and methods: Nonionic surfactant vesicles were prepared using the coacervation phase separation method. A central composite design was employed to statistically optimize formulation variables using Design-Expert software. Three independent variables were evaluated: amount of surfactant (X 1 ), amount of soya lecithin (X 2 ), and amount of cholesterol (X 3 ). The encapsulation efficiency percentage (Y 1 ) and particle size (Y 2 ) were selected as dependent variables. Results and discussion: The optimum formulation (F10) displayed spherical bi-layered vesicles under transmission electron microscopy with optimum particle size of 707.9 nm and high entrapment efficiency as 98.52%. In vitro skin permeation study demonstrated the most sustained release of 84.83 ± 0.153 mg/cm 2 in 24 h. Anti-inflammatory activity of the gel showed a significant (p 5 0.001) higher percentage inhibition as compared to the marketed gel at the same dose. Conclusion: The present study exhibited that BA-loaded proniosomal gel was better in terms of absorption, bioavailability, and release kinetics.

Panfacial fractures present a unique set of problems to the anaesthesiologist and surgeon. Airway management in panfacial fractures is still a challenge to the anaesthesiologist as all modalities available such as orotracheal intubation, nasotracheal intubation, tracheostomy, etc., have their own advantages and disadvantages. When all the conventional modalities to secure airway seem unsuitable then submental route offers an excellent alternative to manage airway in such patients. Here we describe our experience with submental intubation technique in 10 patients with panfacial injuries over a period of two years.

Tecomella undulata (Bignoniaceae) is a monotypic genus and one of the most important deciduous, ornamental shrub or small tree of the acrid zone of India. Locally known as Rohida, Roheda in Hindi, Rakhtroda in Marathi, Dadimacchada, Chalachhada, Dadimapuspaka in Sanskrit mostly found in the Thar desert regions of India and Pakistan. The plant holds tremendous potential of medicinal value and is used in traditional and folklore system of medicines. It has been used traditionally in various ailments like syphilis, swelling, leucorrhoea and leucoderma, enlargement of spleen, obesity, tumours, blood disorders, flatulence and abdominal pain. Tecomella undulata has gained prominence due to presence of some prominent secondary metabolites of great therapeutic potential like stigmasterol, β-sitosterol, α-lapachone, tectol isolated from heartwood, bark and leaf. The present review presents the traditional information and recent scientific update on this plant with therapeutic potential.

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