Safety evaluation of green synthesized<i>Cola nitida</i>pod, seed and seed shell extract-mediated silver nanoparticles (AgNPs) using an<i>Allium cepa</i>assay

Yekeen, Taofeek A.; Azeez, Musibau A.; Akinboro, Akeem; Lateef, Agbaje; Asafa, T. B.; Oladipo, Iyabo C.; Oladokun, Samuel O.; Ajibola, Adewumi A.

doi:10.1016/j.jtusci.2017.06.005

Cited by 28 publications

(22 citation statements)

References 49 publications

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“…Table 1 summarizes the cytotoxic and genotoxic response registered after the exposure of Allium cepa to different concentrations of diverse AgNPs formulations from published data. Most of the formulations assessed reported cytotoxic and genotoxic damage, mainly those that lack of coating agent and the biogenically produced nanoparticles [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Argovit™ Silver Nanoparticles Effects on Allium cepa: Plant Growth Promotion without Cyto Genotoxic Damage

Casillas-Figueroa¹,

Arellano-García²,

Leyva³

et al. 2020

Nanomaterials

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Due to their antibacterial and antiviral effects, silver nanoparticles (AgNP) are one of the most widely used nanomaterials worldwide in various industries, e.g., in textiles, cosmetics and biomedical-related products. Unfortunately, the lack of complete physicochemical characterization and the variety of models used to evaluate its cytotoxic/genotoxic effect make comparison and decision-making regarding their safe use difficult. In this work, we present a systematic study of the cytotoxic and genotoxic activity of the commercially available AgNPs formulation Argovit™ in Allium cepa. The evaluated concentration range, 5–100 µg/mL of metallic silver content (85–1666 µg/mL of complete formulation), is 10–17 times higher than the used for other previously reported polyvinylpyrrolidone (PVP)-AgNP formulations and showed no cytotoxic or genotoxic damage in Allium cepa. Conversely, low concentrations (5 and 10 µg/mL) promote growth without damage to roots or bulbs. Until this work, all the formulations of PVP-AgNP evaluated in Allium cepa regardless of their size, concentration, or the exposure time had shown phytotoxicity. The biological response observed in Allium cepa exposed to Argovit™ is caused by nanoparticles and not by silver ions. The metal/coating agent ratio plays a fundamental role in this response and must be considered within the key physicochemical parameters for the design and manufacture of safer nanomaterials.

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Section: Introductionmentioning

confidence: 99%

Argovit™ Silver Nanoparticles Effects on Allium cepa: Plant Growth Promotion without Cyto Genotoxic Damage

Casillas-Figueroa¹,

Arellano-García²,

Leyva³

et al. 2020

Nanomaterials

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“…Aside the pharmaceutical potentials of C. nitida, different parts of the plant have been employed as microbial substrate to produce enzyme and enhancement of nutritional qualities [ 27 , 28 ] and also for the synthesis of silver and silver-gold alloy nanoparticles [ 29 , 30 , 31 , 32 , 33 , 34 , 35 ] for different biomedical and environmental applications. This work therefore seeks to extend the border of the potential applications of extracts of different parts of kola nut in nanobiotechnology.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional titanium dioxide nanoparticles biofabricated via phytosynthetic route using extracts of Cola nitida: antimicrobial, dye degradation, antioxidant and anticoagulant activities

Akinola

Lateef

Asafa

et al. 2020

Heliyon

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First study of phytosynthesis of TiO 2 NPs using the leaf (KL), pod (KP), seed (KS) and seed shell (KSS) extracts of kola nut tree ( Cola nitida ) is herein reported. The TiO 2 NPs were characterized and evaluated for their antimicrobial, dye degradation, antioxidant and anticoagulant activities. The nearly spherical-shaped particles had λmax of 272.5–275.0 nm with size range of 25.00–191.41 nm. FTIR analysis displayed prominent peaks at 3446.79, 1639.49 and 1382.96 cm −1 , indicating the involvement of phenolic compounds and proteins in the phytosynthesis of TiO 2 NPs. Both SAED and XRD showed bioformation of crystalline anatase TiO 2 NPs which inhibited multidrug-drug resistant bacteria and toxigenic fungi. The catalytic activities of the particles were profound, with degradation of malachite green by 83.48–86.28 % without exposure to UV-irradiation, scavenging of DPPH and H 2 O 2 by 51.19–60.08 %, and 78.45–99.23 % respectively. The particles as well prevented the coagulation of human blood. In addition to the antimicrobial and dye-degrading activities, we report for the first time the H 2 O 2 scavenging and anticoagulant activities of TiO 2 NPs, showing that the particles can be useful for catalytic and biomedical applications.

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“…These plant systems have been frequently used to study cytotoxic and genotoxic effects of nanoparticles on mitotic cell division and they have been considered as well model genetic system [ 32 ]. Yekeen et al [ 33 ] and Yekeen et al [ 34 ] have been reported that the cytotoxic effect of AgNPs on root meristems of Allium cepa used as a model of biological system. Hence, the present study was undertaken to investigate cytotoxic effect of silver nanoparticles on mitotic chromosomes of meristimetic root tip cells of D. polyantha .…”

Section: Introductionmentioning

confidence: 99%

Characterization and cytotoxic effect of biogenic silver nanoparticles on mitotic chromosomes of Drimia polyantha (Blatt. & McCann) Stearn

Daphedar

Taranath

2018

Toxicology Reports

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Safety evaluation of green synthesizedCola nitidapod, seed and seed shell extract-mediated silver nanoparticles (AgNPs) using anAllium cepaassay

Abstract: Safety evaluation of green synthesized Colanitida pod, seed and seed shell extract-mediated silver nanoparticles (AgNPs) using an Alliumcepa assay,

Cited by 28 publications

References 49 publications

Argovit™ Silver Nanoparticles Effects on Allium cepa: Plant Growth Promotion without Cyto Genotoxic Damage

Argovit™ Silver Nanoparticles Effects on Allium cepa: Plant Growth Promotion without Cyto Genotoxic Damage

Multifunctional titanium dioxide nanoparticles biofabricated via phytosynthetic route using extracts of Cola nitida: antimicrobial, dye degradation, antioxidant and anticoagulant activities

Characterization and cytotoxic effect of biogenic silver nanoparticles on mitotic chromosomes of Drimia polyantha (Blatt. & McCann) Stearn

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