Multifunctional titanium dioxide nanoparticles biofabricated via phytosynthetic route using extracts of Cola nitida: antimicrobial, dye degradation, antioxidant and anticoagulant activities

Abstract

First study of phytosynthesis of TiO 2 NPs using the leaf (KL), pod (KP), seed (KS) and seed shell (KSS) extracts of kola nut tree ( Cola nitida ) is herein reported. The TiO 2 NPs were characterized and evaluated for their antimicrobial, dye degradation, antioxidant and anticoagulant activities. The nearly spherical-shaped particles had λmax of 272.5–275.0 nm with size range of 25.00–191.41 nm. FTIR analysis displayed prominent peaks at 3446.79, 1639.49 and 1382.96 cm −1 , indicating the involvement of phenolic compounds and proteins in the phytosynthesis of TiO 2 NPs. Both SAED and XRD showed bioformation of crystalline anatase TiO 2 NPs which inhibited multidrug-drug resistant bacteria and toxigenic fungi. The catalytic activities of the particles were profound, with degradation of malachite green by 83.48–86.28 % without exposure to UV-irradiation, scavenging of DPPH and H 2 O 2 by 51.19–60.08 %, and 78.45–99.23 % respectively. The particles as well prevented the coagulation of human blood. In addition to the antimicrobial and dye-degrading activities, we report for the first time the H 2 O 2 scavenging and anticoagulant activities of TiO 2 NPs, showing that the particles can be useful for catalytic and biomedical applications.

Unmodified Titanium Dioxide Nanoparticles as a Potential Contrast Agent in Photon Emission Computed Tomography

“…TiO 2 -NPs have been used in the food industry since 1996 when the US Food and Drug Administration approved it as a food supplement [17]. TiO 2 -NPs are also used for electrostatic properties in terms of electrostatic potentials and ion distributions [18] for dye-degrading activities, H 2 O 2 scavenging, and anticoagulant activities [19] to enhance the glasses' radiation protection properties along with bioactive glasses [20] as nanocarriers for drug delivery [21] and as a nano-drug for treating diseases [22]. The idea of agents for two modes of therapy enhancement and image contrast is one field that remains largely unexplored.…”

Potentialities of bioinspired metal and metal oxide nanoparticles in biomedical sciences

“…In addition, it was observed that these bioinspired titanium oxide nanoparticles maintained the morphology of red blood cells. 220 Apart from the plants showing anti-coagulation activities, several other organisms (like Hirudinea) exhibit excellent anti-coagulation properties, and therefore can be utilized to synthesize various metal and metal oxide nanoparticles to exhibit anti-coagulation activity.…”

Recent advances in functionalization of nanotextiles: A strategy to combat harmful microorganisms and emerging pathogens in the 21st century

“…In addition to curtailing MDR strains, metal nanoparticles also possess several other beneficial biomedical attributes. These include antioxidant [ 167 , 168 , 169 , 170 , 171 ], anticoagulant [ 4 , 172 , 173 , 174 , 175 ], thrombolytic [ 4 , 172 , 173 ], anti-inflammatory [ 176 , 177 ], anti-diabetic [ 178 , 179 , 180 ], anti-cancer [ 179 , 180 , 181 , 182 , 183 ] and wound healing [ 184 , 185 ] properties. In translational studies, nanoparticle-based antibiotic delivery systems can be created by coating nanoparticles on implanted devices, wound dressings, bone cement and dental materials [ 186 , 187 , 188 , 189 , 190 ] to kill germs and prevent infections.…”