Safety evaluation of alkaline cellulase

Enzymes in cleaning products: An overview of toxicological properties and risk assessment/management

“…Note that these have involved, on some occasions, use of appropriately modified assays, since the methods are designed for chemicals rather than proteins but tests are nevertheless carried out, driven largely by regulatory requirements. The results reflect the outcome that would be predicted based on intrinsic properties of enzymes and given appropriate methods of production (Pariza and Foster, 1983;Ashby et al, 1987;Greenough et al, 1991Greenough et al, , 1996Hjortkjaer et al, 1986Hjortkjaer et al, , 1993Pariza and Johnson, 2001;van Dijck et al, 2003;REACH, 2010a,b). Importantly, these tests also ensure that any residual materials from the production fermentation are also free from genotoxic effects.…”