Safety assessment of iron EDTA [sodium iron (Fe3+) ethylenediaminetetraacetic acid]: summary of toxicological, fortification and exposure data

Heimbach, James T.; Rieth, Susan; Mohamedshah, Farida Y.; Slesinski, R.S.; Samuel-Fernando, P.; Sheehan, T. M. T.; Dickmann, Robin S.; Borzelleca, Joseph F.

doi:10.1016/s0278-6915(99)00125-8

Cited by 68 publications

(46 citation statements)

References 39 publications

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“…Regarding to oral human exposure, Fe(III)-EDTA salts are considered safe and used as an iron supplement 22 source. However, a recent study proposes carbonyl iron as a better fortificant than NaFeEDTA salts, because it resulted to be less toxic when tested in acute toxicity in young rats 23 .…”

Section: Ecotoxicological Risks Of Edtamentioning

confidence: 99%

EDTA: the chelating agent under environmental scrutiny

Oviedo¹,

2003

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Recebido em 6/3/03; aceito em 28/4/03 EDTA: THE CHELATING AGENT UNDER ENVIRONMENTAL SCRUTINY. The chelating agent EDTA (ethylenediaminetetraacetic acid) is a compound of massive use world wide with household and industrial applications, being one of the anthropogenic compounds with highest concentrations in inland European waters. In this review, the applications of EDTA and its behavior once it has been released into the environment are described. At a laboratory scale, degradation of EDTA has been achieved; however, in natural environments studies detect poor biodegradability. It is concluded that EDTA behaves as a persistent substance in the environment and that its contribution to heavy metals bioavailability and remobilization processes in the environment is a major concern.

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Section: Ecotoxicological Risks Of Edtamentioning

confidence: 99%

EDTA: the chelating agent under environmental scrutiny

Oviedo¹,

2003

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“…A study reported NaFeEDTA was safe. 19 In conclusion, both daily and twice weekly iron supplementation for a one-month period significantly increase hemoglobin, hematocrit, MCV, MCH and MCHC levels. Twice-weekly iron supplementation is as effective as daily iron supplementation for the treatment of IDA.…”

Section: Resultsmentioning

confidence: 77%

Ferric sodium edetate therapy in children with iron deficiency anemia

Moningkey

Mantik

Pateda

2015

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“…However, conventional modification method using single chitosan crosslinks with glutaraldehyde generally leads to the decrease of functional groups and loading capacity. Whereas, ethylenediaminetetraacetate (EDTA), the polyamine polycarboxylate chelator is known for its capacity to form complexes with metal ions and radionuclide [20]. Moreover, in comparison with other chelating agents, EDTA presents a high level of complexing capacity with respect to heavy metals [21].…”

Section: Introductionmentioning

confidence: 99%