No abstract

Health-care providers' beliefs about childhood cancer treatment are characterized by much uncertainty and contradiction. This likely affects adherence of health-care providers, parents, and childhood cancer treatment outcome.

Asian Pac J Cancer Prev, 15 (8), 3593-3599 IntroductionChildhood cancer survival is lower in low-income countries (<35%) than in high-income countries (80%) (Mostert et al., 2011;Rohani-Rasaf et al., 2012). Several factors contribute to this discrepancy: death from toxicity, relapse and non-adherence. Treatment abandonment, a severe form of non-adherence and seldom seen in high-income countries, is the most prominent factor. Recently, various studies indicated that nonadherence and abandonment are not merely caused by socio-economic hardships, but also by psychological aspects and side-effects of chemotherapy (Yeh et al., 1999;De Oliveira et al., 2005;Bonilla et al., 2009;Sitaresmi et al., 2010;Wang et al., 2011).Chemotherapy-related side-effects may deteriorate the child's quality of life and hinder families' acceptance and adherence with prescribed medication (Yeh et al.,1999;

Dengue hemorrhagic fever (DHF) is an acute fever disease with high mortality and morbidity in many regions of the world. Leucopenia and thrombocytopenia are two of several laboratory findings that could be found in the course of DHF. This was an analytical retrospective study with a cross sectional design. Samples were patients diagnosed with DHF in Prof. Dr. R.D Kandou General Hospital Manado during the period of 2012. The inclusion criteria were patients <15 years, were diagnosed as DHF according to WHO 1997 criteria, and were examined for platelet and white blood cell count. This study used the medical record data which were analyzed statistically by using the Pearson's correlation test. There were 137 children with DHF during the period of 2012. Samples were 56 children that fulfiled the inclusion criteria. The Pearson correlation test showed a P value 0.801 and correlation coefficient r = -0.034 that indicated that there was a negative correlation which was not significant. Conclusion: There was no significant correlation between the number of thrombocytes and leukocytes in children with dengue hemorrhagic fever.Keywords: dengue hemorrhagic fever, leukocyte, thrombocyteAbstrak: Demam berdarah dengue (DBD) merupakan penyakit demam akut dengan morbiditas dan mortalitas yang tinggi di banyak daerah di dunia. Leukopenia dan trombositopenia merupakan dua temuan laboratorik yang sering ditemukan pada DBD. Penelitian ini bersifat analitik retrospektif dengan pendekatan potong lintang. Sampel penelitian ialah pasien anak yang terdiagnosis DBD di RSUP Prof. Dr. R.D. Kandou Manado selama periode tahun 2012. Pasien yang masuk dalam kriteria inklusi ialah pasien < 15 tahun, telah terdiagnosis menurut kriteria WHO 1997, serta melakukan pemeriksaan laboratorium trombosit dan leukosit. Penelitian ini menggunakan catatan rekam medik, dan untuk analisis statistik digunakan Pearson’s correlation test. Terdapat 137 anak dengan demam berdarah dengue pada periode 2012 dan 56 anak menjadi sampel dalam penelitian ini. Hasil penelitian melalui uji korelasi Pearson mendapatkan nilai P = 0,801 dan koefisien korelasi r = -0,034 yang berarti bahwa korelasi tidak bermakna, dengan kekuatan korelasi lemah dan arah korelasi negatif. Simpulan: Tidak terdapat hubungan yang bermakna antara jumlah trombosit dan leukosit pada pasien anak demam berdarah dengue.Kata kunci: demam berdarah dengue, leukosit, trombosit

Background The prevalence of iron deficiency anemia (IDA) remains high in Indonesian children. When anemia is detected in a patient, the physician's task is to identify the cause, address it, provide iron therapy, and prevent recurrence. However, prevention is best done by early detection. The reticulocyte hemoglobin equivalent (Ret-He) is a direct measurement of iron level in reticulocytes recently produced in the bone marrow. The Ret-He measurement may be an early indicator of iron deficiency, as it is sensitive at the initial stage of the condition. Objective To assess for a relationship between Ret-He and IDA as well as to evaluate the usefulness of Ret-He for diagnosing IDA in children. Methods This analytic, observational study with cross-sectional approach included 50 children aged 6-12 years and was performed from November 2013 to March 2014. The subjects were divided into IDA or non-IDA groups, based on ferritin levels. A correlation analysis using logistic regression was performed and the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and odds ratio (OR) were calculated. Results were considered to be statistically significant for P values <0.05. Results A low Ret-He level was significantly associated with IDA in children (P=0.005). The Ret-He cut-off point of 27.8 pg/L had sensitivity of 43.8%, specificity 85.3%, PPV 58.3%, and NPV 76.3%, with OR 4.5 (95%CI 1.1 to 17.7). Conclusion We find a significant positive relationship between Haemoglobin (Hb) and Ret-He in children, A low level of Ret-He is associated with greater risk of IDA in children. The Ret-He has a high specificity. As such, Ret-He may be useful as a screening tool for early detection of IDA in children. [Paediatr Indones. 2016;56:90-4.].

Diarrhea is an abnormal excretion of stool or dilute form of feces with abnormal frequency. Neonatal can be diagnosed with diarhhea when the frequency of bowel movements is more than 4 times per day. In babies aged 1 month old or older, diarhhea is diagnosed when the frequency is more than 3 times per day. Until today, diarrhea is still a health problem in Indonesia as well as in other developing countries. Diarrhea that occurs less than 14 days is called acute diarhhea. There are many causes of diarrhea inter alia infectious and non infectious diseases. The complications of acute diarrhea can be dehydration, hypovolemic shock, hypokalemia, and hypoglycemia. Hematological examination of acute diarrhea patients with severe dehydration can be increased hematocrit and hemoglobin. This study aimed to obtain the hematological results of acute diarrhea patients at the Paediatrics Department of Prof Dr. R. D. Kandou Hospital, Manado. This was a retrospective descriptive study by using medical records. In this study, there were 276 patients in the period November 2010 - November 2011. The results showed that of the 276 patients with acute diarrhea, 157 patients were males (55.88%) and 115 patients were females (43.12%). Concerning the hematological examination, 205 patients (74.27%) had normal hematocrit, 189 patients (68.48%) had normal hemoglobin, and 224 patients (81.16%) had normal leukocyte counts, and 196 patients (71.01%) had normal platelet counts. There were 273 patients (98.91 %) with length of treatment 1 - ≤14 days meanwhile 3 patients (1.09%) with length of treatment >14 days. Keywords: acute diarrhea, hematological examination, childrenAbstrak: Diare adalah pengeluaran tinja yang tidak normal atau bentuk tinja yang encer dengan frekuensi lebih banyak dari biasanya. Neonatus dinyatakan diare bila frekuensi buang air besar sudah lebih dari 4 kali, sedangkan bayi berumur lebih dari 1 bulan dan anak, bila frekuensinya lebih dari 3 kali, sampai saat ini, diare masih menjadi masalah kesehatan di Indonesia juga dinegara-negara berkembang, diare disebut akut bila terjadi kurang dari 14 hari, diare dapat disebabkan oleh berbagai hal yaitu infeksi maupun non infeksi, pada diare akut dapat terjadi komplikasi antara lain dehidrasi, renjatan hipovolemik, hipokalemia, hipoglekemia, pemeriksaan hematologi pasien diare akut dapat terjadi peningkatan pada beberapa pemeriksaan darah seperti peningkatan hematokrit dan hemoglobin pada keadaan dehidrasi berat. Penelitian ini bertujuan untuk melihat gambaran hematologi pada pasien diare akut di bagian Ilmu Kesehatan Anak RSUP Prof. Dr. R. D. Kandou Manado. Penelitian ini menggunakan metode deskriptif retrospektif dengan memanfaatkan catatan rekam medik. Sampel penelitian ini 276 pasien dengan diare akut pada periode November 2010 – November 2011. Dari 276 pasien, didapatkan laki-laki 157 (55,88%) pasien dan perempuan 115 (43,12%) pasien. Pada pemeriksan hematologi didapatkan nilai hematokrit normal 205 (74,27%) pasien, hemoglobin normal 189 (68,48%) pasien, hitung leukosit normal 224 (81,16%) pasien, dan hitung trombosit normal 196 (71,01%) pasien. Terdapat 273 (98,91%) pasien dengan lama perawatan 1 - ≤14 hari dan 3 (1,09%) pasien dengan lama perawatan >14 hari.Kata kunci: diare akut, pemeriksaan hematologi, pasien anak

No abstract

Indonesian HCP have more positive views about CAM than their Dutch colleagues. Both Dutch and Indonesian HCP consider their knowledge about CAM to be inadequate. Therefore, education programs about CAM tailored to the needs of HCP are recommended, knowing that CAM is used frequently.