Safety and feasibility of a combined exercise intervention for inoperable lung cancer patients undergoing chemotherapy: A pilot study

Effect of physical exercise on muscle mass and strength in cancer patients during treatment—A systematic review

“…In this study, patients with advanced incurable cancer were randomized to eight weeks of CAE performed twice weekly in a supervised hospital setting, or to usual care. The increased grip strength in the CAE relative to UC supports previous uncontrolled trials in advanced cancer [47,48] on efficacy of exercise on muscle strength also in this population. In conclusion, the findings from our review support the effect of exercise on muscle strength in cancer patient undergoing curative treatment.…”

“…As only RCT's were included, two uncontrolled trials performed in patients with advanced lung cancer [47,48] were not described in our results. These trials showed improvement in muscle strength after eight weeks of CAE but none of these studies used muscle mass as outcome.…”

Exercise and Nutrition Interventions in Advanced Lung Cancer: A Systematic Review

“…37 and Quist et al 41 found no statistically significant changes in self-reported fatigue in participants who completed a physical activity intervention. The study by van der Meij et al 39 also found no significant differences in fatigue as assessed within the European Organisation for Research and Treatment of Cancer 30-item quality-of-life questionnaire (eortc qlq-C30: p = 0.57 at week 3, p = 0.95 at week 5).…”

“…Tozer et al 36 found significant mean changes (p < 0.05) in the percentage change of body weight in an intervention group treated with cysteine-rich 1 open-label RCT with a prospective reference group (37 participants) 40 1 Multi-site double blinded RCT (66 participants) 36 1 Single site double blinded RCT (42 participants) 38.39 Physical activity (n=2) 2 Prospective, single-arm cohort studies (48 participants) 37,41 Records excluded (n=15)…”

Pulmonary Rehabilitation in lung cancer

“…Even in this case, some case studies enrolled a non-homogeneous sample population; Adamsen [51], for example, has found, in a group of subjects suffering from lung and breast cancer, not only significant improvements in O 2 -Peak-max and muscle strength, but also an increase in the time dedicated to physical activities rather than sedentary time. Positive effects have also been reported by prospective studies [52][53][54]. A recent randomized study demonstrated the efficacy of aerobic exercise in improving exercise capacity in a group of patients with adenocarcinoma and receiving targeted chemotherapy [55].…”