2014
DOI: 10.5935/medicalexpress.2014.01.06
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Abstract: OBJECTIVES: Off-pump coronary artery bypass grafting occurrence increases constantly. However transient low cardiac output events occur during this procedure requiring aggressive volume replacement, which may lead to hypervolemia and its complications. METHOD: This study evaluates the safety and efficacy of a hypertonic-hyperoncotic NaCl solution (6% hydroxyethylamide + 7.5% sodium chloride) versus isotonic saline during the creation of anastomosis in the lateral wall of the left ventricle. In each case, 250 m… Show more

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Cited by 3 publications
(3 citation statements)
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“…This relative increase in intravascular volume serves to increase preload 61,65,67,68 . Thus, when compared with equivalent volumes of NS, resuscitation with HS results in a more profound increase in MAP, CO, and stroke volume in those who are critically ill 65,69 . Beyond its hemodynamic effects, resuscitation with HS may also have an impact on systemic inflammation 67 .…”
Section: Resultsmentioning
confidence: 99%
“…This relative increase in intravascular volume serves to increase preload 61,65,67,68 . Thus, when compared with equivalent volumes of NS, resuscitation with HS results in a more profound increase in MAP, CO, and stroke volume in those who are critically ill 65,69 . Beyond its hemodynamic effects, resuscitation with HS may also have an impact on systemic inflammation 67 .…”
Section: Resultsmentioning
confidence: 99%
“…It is consequently safe to state that hypertonic acetate is not an adequate resuscitative solution. In the only report cited in this review which is not an animal model, Mola et al [ 47 ] tested the safety and efficacy of hypertonic saline vs isotonic saline in off-pump coronary artery bypass grafting and found that the solution is safe and raised venous pressure return during the critical period of arterial anastomosis. As reported above, Dekker et al [ 38 ] found that treatment of traumatic brain injury plus hemorrhage with hypertonic saline + hydroxyethylstarch is less effective that normal saline treatment.…”
Section: Resultsmentioning
confidence: 99%
“…This relative increase in intravascular volume serves to increase preload [60,74,76,77]. Thus, when compared to equivalent volumes of NS, resuscitation with HS results in a more profound increase in MAP, CO and stroke volume in those who are critically ill [74,78].…”
Section: Resuscitation With Hypertonic Saline Following Cardiac Surgerymentioning
confidence: 99%