Safety and efficacy of concurrent application of oral pentosan polysulfate and subcutaneous low-dose heparin for patients with interstitial cystitis

Ophoven, Arndt van; Heinecke, Achim; Hertle, L.

doi:10.1016/j.urology.2005.04.056

Cited by 25 publications

(9 citation statements)

References 17 publications

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“…This metaanalysis favored treatment compared with placebo. Moreover, combination of PPS with low-dose subcutaneous heparin demonstrated superior outcomes versus PPS alone [58]. Studies on impact of hydroxyzine have demonstrated a beneficial effect, but are limited in power and study design, and as such further investigation is required [59].…”

Section: Medical Therapymentioning

confidence: 99%

Interventional Therapies for Controlling Pelvic Pain: What is the Evidence?

Green

Cohen

Finkenzeller

et al. 2010

Curr Pain Headache Rep

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Chronic pelvic pain (CPP) has many potential causes and is often a complex disorder with multiple contributing etiologies. The evaluation and treatment of women with CPP often requires a multidimensional approach. The treatment of CPP consists of two approaches: 1) treatment of pain itself or global treatment, and 2) treatment of disease-specific etiologies. Most often, treatment requires a combination of both approaches. This article reviews recent literature in the global treatment of CPP, including pharmacologic, psychotherapy, and neuroablative, as well as specific interventions for endometriosis, interstitial cystitis, pelvic adhesive disease, adenomyosis, and pelvic venous congestion.

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Section: Medical Therapymentioning

confidence: 99%

Interventional Therapies for Controlling Pelvic Pain: What is the Evidence?

Green

Cohen

Finkenzeller

et al. 2010

Curr Pain Headache Rep

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“…19 Both drugs are thought to aid the recovery of dysfunctional bladder mucus by reducing epithelial permeability and protecting the bladder from toxic substances. The 41 patients were given heparin (3×5000 IU a day for two days, then 2×5000 IU a day for 12 days), and 17 patients taking pentosan polysulfate sodium only served as controls.…”

Section: Pentosan Polysulfate Sodium and Heparinmentioning

confidence: 99%

The management of interstitial cystitis or painful bladder syndrome in women

Marinkovic

Moldwin

Gillen

et al. 2009

BMJ

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“…The compounds used for this purpose are intravesical heparin [26,27] and/or oral pentosan polysulfate [28][29][30][31][32][33][34]. These compounds provide clinically relevant and significant relief of symptoms in most patients, not just minor measurable effects.…”

Section: Heparinoid Compoundsmentioning

confidence: 99%

Advances in the treatment of interstitial cystitis

Parsons

2006

Expert Opinion on Pharmacotherapy

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Recent years have brought dramatic advances in the clinician's ability to offer effective pharmacotherapy to patients who have interstitial cystitis. Medical treatments have been developed and applied to reduce the interstitial cystitis symptoms of pelvic pain and urinary urgency/frequency, and to address underlying causes of the disorder. In addition, advances in the understanding of the natural history of interstitial cystitis have revealed that it is insidiously progressive and the classical definition--rare, severe and difficult to treat--is in fact the relatively uncommon, advanced stage of a disorder that affects most individuals in a mild-to-moderate and readily treatable form. This recognition has led to the identification of large numbers of previously unsuspected cases of interstitial cystitis, and the successful treatment of many individuals in the early stages of interstitial cystitis when it is far more responsive to therapy. A heparinoid-based multimodal medical regimen can effectively control symptoms and address disease pathophysiology in the majority of cases. Intravesical therapeutic solutions are new and promising adjunctive therapies that can offer immediate symptom relief during symptom flares, and for patients who are just beginning medical therapy.

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Safety and efficacy of concurrent application of oral pentosan polysulfate and subcutaneous low-dose heparin for patients with interstitial cystitis

Cited by 25 publications

References 17 publications

Interventional Therapies for Controlling Pelvic Pain: What is the Evidence?

Interventional Therapies for Controlling Pelvic Pain: What is the Evidence?

The management of interstitial cystitis or painful bladder syndrome in women

Advances in the treatment of interstitial cystitis

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