The management of interstitial cystitis or painful bladder syndrome in women

Marinkovic, Serge P.; Moldwin, Robert; Gillen, Lisa M.; Stanton, Stuart L.

doi:10.1136/bmj.b2707

Cited by 31 publications

(15 citation statements)

References 22 publications

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“…Prednisone and cyclosporine have also been studied as immunosuppressive agents to reduce bladder inflammation in the management of IC. They are considered second-line agents associated with varied symptomatic relief and relatively few side effects [61][62][63].…”

Section: Medical Therapymentioning

confidence: 99%

Interventional Therapies for Controlling Pelvic Pain: What is the Evidence?

Green

Cohen

Finkenzeller

et al. 2010

Curr Pain Headache Rep

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Chronic pelvic pain (CPP) has many potential causes and is often a complex disorder with multiple contributing etiologies. The evaluation and treatment of women with CPP often requires a multidimensional approach. The treatment of CPP consists of two approaches: 1) treatment of pain itself or global treatment, and 2) treatment of disease-specific etiologies. Most often, treatment requires a combination of both approaches. This article reviews recent literature in the global treatment of CPP, including pharmacologic, psychotherapy, and neuroablative, as well as specific interventions for endometriosis, interstitial cystitis, pelvic adhesive disease, adenomyosis, and pelvic venous congestion.

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Section: Medical Therapymentioning

confidence: 99%

Interventional Therapies for Controlling Pelvic Pain: What is the Evidence?

Green

Cohen

Finkenzeller

et al. 2010

Curr Pain Headache Rep

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“…5 Further, in disorders of the lower urinary tract, sensations of pain and a sudden overpowering urge to void are common symptoms. 6 It is well recognized that both acute pain and distraction arising from somatic signals can interfere with cognitive function in otherwise healthy adults. 7,8 There is also strong neurobiological evidence implicating common anterior cortical regions in the control of pain and aspects of cognitive function, such as attention and working memory (e.g.…”

Section: Introductionmentioning

confidence: 99%

The effect of acute increase in urge to void on cognitive function in healthy adults

Lewis

Snyder

Pietrzak

et al. 2010

Neurourology and Urodynamics

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“…The traditional definition of this illness is chronic sterile bladder inflammation of unknown etiology and it has not been possible to prove any causative pathogenic agent for this syndrome [2,3]. Currently there are four major hypotheses of pathogenesis: 1) autoimmunity, 2) deficiency of the glycosaminoglycan layer causing increased bladder wall permeability, 3) neurogenic inflammation and 4) chronic infection [4].…”

Section: Introductionmentioning

confidence: 99%

Alterations of microbiota in urine from women with interstitial cystitis

et al. 2012

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BackgroundInterstitial Cystitis (IC) is a chronic inflammatory condition of the bladder with unknown etiology. The aim of this study was to characterize the microbial community present in the urine from IC female patients by 454 high throughput sequencing of the 16S variable regions V1V2 and V6. The taxonomical composition, richness and diversity of the IC microbiota were determined and compared to the microbial profile of asymptomatic healthy female (HF) urine.ResultsThe composition and distribution of bacterial sequences differed between the urine microbiota of IC patients and HFs. Reduced sequence richness and diversity were found in IC patient urine, and a significant difference in the community structure of IC urine in relation to HF urine was observed. More than 90% of the IC sequence reads were identified as belonging to the bacterial genus Lactobacillus, a marked increase compared to 60% in HF urine.ConclusionThe 16S rDNA sequence data demonstrates a shift in the composition of the bacterial community in IC urine. The reduced microbial diversity and richness is accompanied by a higher abundance of the bacterial genus Lactobacillus, compared to HF urine. This study demonstrates that high throughput sequencing analysis of urine microbiota in IC patients is a powerful tool towards a better understanding of this enigmatic disease.

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The management of interstitial cystitis or painful bladder syndrome in women

Cited by 31 publications

References 22 publications

Interventional Therapies for Controlling Pelvic Pain: What is the Evidence?

Interventional Therapies for Controlling Pelvic Pain: What is the Evidence?

The effect of acute increase in urge to void on cognitive function in healthy adults

Alterations of microbiota in urine from women with interstitial cystitis

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