S-Persulfidation: Chemistry, Chemical Biology, and Significance in Health and Disease

An Innovative Hydrogen Peroxide‐Sensing Scaffold and Insight Towards its Potential as an ROS‐Activated Persulfide Donor

“…Since the early 2000s there has been an exponential increase in the number of studies that have been published related to hydrogen sulfide and its physiological significance. However, with protein persulfidation (Cys‐SH to Cys‐SSH) believed to be a primary mechanism by which H 2 S relays its signaling, many of the physiological effects that were once ascribed to H 2 S may, in fact, be mediated by other reactive sulfur species (RSS), such as persulfides (RSSH) and polysulfides [7–10] …”

“…However,w ith protein persulfidation (Cys-SH to Cys-SSH) believed to be ap rimary mechanism by which H 2 Sr elays its signaling,m any of the physiological effects that were once ascribed to H 2 Sm ay,i nf act, be mediated by other reactive sulfur species (RSS), such as persulfides (RSSH) and polysulfides. [7][8][9][10] Like hydrogen sulfide,p ersulfides also display enhanced nucleophilicity and are more potent reductants than their thiol counterparts within ab iological setting (i.e.g luta-thione). [11,12] This is attributed to both the alpha effect and the suppressed pK a of RSSH which results in the more reactive RSS À being its dominant form at neutral pH.…”

Is Hydrogen Sulfide a Concern During Treatment of Lung Adenocarcinoma With Ammonium Tetrathiomolybdate?

“…H 2 S was also involved in VitB 12 -induced S-adenosylmethionine (SAM) generation (16), and high VitB 12 has been found to raise the risk of lung cancer (17). Notably, in lung cancer tissues, endogenous H 2 S and its producing enzymes, like cystathionine beta-synthase (CBS), cystathionine gamma lyase (CSE, also known as CTH) and 3-mercaptopyruvate sulfurtransferase (3-MST), are highly expressed thereby benefiting cancer development (18,19). N 6 -Methyladenosine (m 6 A) methylation is one major type of mRNA modification, dynamically modulated by the corresponding writers, erasers and readers (20).…”

Metabolic Reprogramming of Sulfur in Hepatocellular Carcinoma and Sulfane Sulfur-Triggered Anti-Cancer Strategy

“…Studies supported that many of garlic's effects are attributed to the generation of sulfane sulfur, a reactive sulfur species (RSS) (Iciek et al, 2001;Iciek et al, 2012). For human beings, persulfide (RSSH), polysulfide (RSS n R), and thiosulfate (RSSO 3 ) are major forms of sulfane sulfur in the body (Yuan et al, 2017;Akaike et al, 2017;Alvarez et al, 2017;Yang et al, 2019a;Liu H. et al, 2019). Additionally, some endogenous RSS, like cystine, cysteine, homocysteine, methionine, glutathione, and hydrogen sulfide (H 2 S), are not sulfane sulfur per se, but can be metabolized to produce sulfane sulfur (Jackson et al, 2012).…”