Metabolic Reprogramming of Sulfur in Hepatocellular Carcinoma and Sulfane Sulfur-Triggered Anti-Cancer Strategy

Zhang, Ximing; Chen, Mianrong; Ni, Xiang; Wang, Yingying; Zheng, Xue; Zhang, Hui; Xu, Shi; Liu, Jinbao

doi:10.3389/fphar.2020.571143

Cited by 11 publications

(13 citation statements)

References 40 publications

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“…The stage-dependent downregulation of CBS in hepatocellular carcinoma was also demonstrated recently in a third, independent patient dataset [ 85 ]. In hepatocellular carcinoma – once again, in contrast to the other tumors discussed in the previous sections – high CBS mRNA expression is associated with better clinical outcomes, as shown by multiple independent analyses of large clinical datasets [ 55 , 80 , 86 , 87 ]. According to the Human Protein Atlas (264 high and 101 low CBS expressor patients), a marked difference can be found in 5-year survival in liver cancer, once again, high CBS predicting significantly better (p < 0.01) survival ( Fig.…”

Section: Cbs Expression In Various Human Cancers: Correlation With Cl...mentioning

confidence: 99%

Emerging roles of cystathionine β-synthase in various forms of cancer

Ascenção¹,

Szabó²

2022

Redox Biology

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Section: Cbs Expression In Various Human Cancers: Correlation With Cl...mentioning

confidence: 99%

Emerging roles of cystathionine β-synthase in various forms of cancer

Ascenção¹,

Szabó²

2022

Redox Biology

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“…Among these safe quantum dots, sulfur quantum dots (SQDs) are of interest because of sulfur’s high biological activity, including antibacterial and antitumor activity. , The first study on the synthesis of SQDs from CdS QDs was published by Li et al. in 2014 .…”

Section: Introductionmentioning

confidence: 99%

“…12 Among these safe quantum dots, sulfur quantum dots (SQDs) are of interest because of sulfur's high biological activity, including antibacterial and antitumor activity. 13,14 The first study on the synthesis of SQDs from CdS QDs was published by Li et al in 2014. 15 Since then, several synthesis methods were reported that either used sublimed elemental sulfur or sulfur-containing compounds like sodium sulfide as a precursor material.…”

Section: ■ Introductionmentioning

confidence: 99%

Sulfur Quantum Dots as Fillers in Gelatin/Agar-Based Functional Food Packaging Films

Priyadarshi

Riahi

Rhim

et al. 2021

ACS Appl. Nano Mater.

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The present work is the first attempt to study the applicability of sulfur quantum dots (SQDs) as functional fillers for food packaging biopolymer films. SQDs were prepared via hydrothermal synthesis using sublimated sulfur powder. The SQDs were 8.7 nm in size and consisted of an elemental sulfur core stabilized by PEG-400 confirmed by TEM, FTIR, and XPS characterization. The SQDs exhibited a high surface charge of −13.9 mV, indicating good dispersion in aqueous suspensions. In addition, the SQDs showed high antioxidant and antimicrobial activities with almost negligible toxicity toward L929 cells even at prolonged exposure of 72 h. The addition of SQDs to the gelatin/agar blend films increased the UV-barrier property without compromising color and transparency. The composite film showed excellent antioxidant activity, a moderate bactericidal effect on Listeria monocytogenes, and an inhibitory effect on Escherichia coli. The SQDs are likely to be value-added, low-cost, safe, and multifunctional nanofillers for preparing functional films in active packaging applications.

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“…Moreover, we investigated hypermethylated OAT was most prominently associated with increased sulfur metabolism. Dampened sulfur metabolism in HCC was found to facilitate tumor cell viability, 27 indirectly supporting a metabolic basis of OAT hypermethylation affecting OSCC prognosis. It is well‐certified that radiotherapy induces metabolic reprogramming in the TME, which is critical for anticancer efficacy and long‐term outcomes after treatment 28 .…”

Section: Discussionmentioning

confidence: 78%

Differential OAT methylation correlates with cell infiltration in tumor microenvironment and overall survival postradiotherapy in oral squamous cell carcinoma patient

Sun

Yang

Cai

et al. 2022

J Oral Pathology Medicine

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Background: Given that DNA methylation and tumor microenvironment (TME) are susceptible to radiotherapy, we aimed to figure out specific differential DNA methylation to reflect oral squamous cell carcinoma (OSCC) prognosis and associated effect on TME changes postradiotherapy, performing as an efficient biomarker.Materials and Methods: Differentially methylation analysis was performed using data from The Cancer Genome Atlas. Curves of Kaplan-Meier (K-M) survival, cumulative hazard and events, Cox proportional hazards, and linear regression model were conducted to screen and validate differential methylation genes, while multiple regression equation to analyze if ornithine aminotransferase (OAT) methylation correlates with radiotherapy. For correlation between OAT methylation and immune infiltrates, CIBERSORT and ESTIMATE algorithms were performed, following gene set enrichment analysis (GSEA) and ssGSEA analysis to evaluate biological process.Results: Compared to normal tissues, only OAT in OSCC was differential significantly by K-M analysis (p = 0.0364). OAT hypermethylation was associated with increased overall survival (hazard ratio: 0.65, p = 0.0358). Radiotherapy correlated with OAT methylation (β = À0.01, p = 0.0061); most patients with OAT hypermethylation were radiation-sensitive. Hypomethylated OAT correlated with higher cell infiltrations in TME. Neuroactive ligand-receptor interaction was most significantly related to OAT methylation (p = 9.2eÀ10). Sulfur metabolism was the most significantly in OAT hypermethylation group (p = 0.0041) and RIG-I-like receptor in OAT hypomethylation group (p = 0.0094). Conclusion:OAT methylation can serve as a predictor of OSCC prognosis postradiotherapy with potential mechanism by changing cell infiltrations in TME, but further experimental study deserves to carry out confirming the role and mechanism of OAT methylation in OSCC.

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Metabolic Reprogramming of Sulfur in Hepatocellular Carcinoma and Sulfane Sulfur-Triggered Anti-Cancer Strategy

Cited by 11 publications

References 40 publications

Emerging roles of cystathionine β-synthase in various forms of cancer

Emerging roles of cystathionine β-synthase in various forms of cancer

Sulfur Quantum Dots as Fillers in Gelatin/Agar-Based Functional Food Packaging Films

Differential OAT methylation correlates with cell infiltration in tumor microenvironment and overall survival postradiotherapy in oral squamous cell carcinoma patient

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