Reactive sulfur species (RSS) play regulatory roles in biological systems. Many RSS are highly reactive and transient molecules, making their study difficult. RSS donors or precursors, which are used to specifically produce or deliver RSS, are useful research tools, as well as possible therapeutic agents. In this Minireview, we summarized the chemical strategies that have been used in the design of donors/precursors of hydrogen sulfide relevant RSS (including hydrogen sulfide, hydrogen polysulfides, persulfides, and S‐nitroso‐hydrogen sulfide). The potential problems of applying these strategies in biological settings are also discussed.
Li et al. ATTM-Produced H 2 S Promotes LUAD m 6 A but also upregulated H 2 S-producing enzymes. Exogenous H 2 S application mimicked ATTM's aforementioned effects, but the effects could be weakened by zinc-induced H 2 S scavenging. Collectively, H 2 S impedes ATTM-induced anticancer effects through YTHDF1-dependent PRPF6 m 6 A methylation in lung adenocarcinoma cells.
Persulfides are receiving increased attention due to their links to hydrogen sulfide (H 2 S) and hydrogen polysulfide (H 2 S n ). Their close analogues selenyl sulfides (RSeSHs), however, have limited literature precedent, and their reactivity and possible role in biology are largely unknown. Here, we devised an acyl selenyl sulfide template to study RSeSH chemistry. Their stability and reactivity toward amines/thiols were studied. These compounds can produce H 2 S or H 2 S 2 under different conditions, suggesting that RSeSHs are possible intermediates.
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