S-Nitrosated human serum albumin dimer as novel nano-EPR enhancer applied to macromolecular anti-tumor drugs such as micelles and liposomes

Kinoshita, Ryô; Ishima, Yu; Ikeda, Mayumi; Kragh‐Hansen, Ulrich; Fang, Jun; Nakamura, Hideaki; Chuang, Victor Tuan Giam; Tanaka, Ryota; Maeda, Hitoshi; Kodama, Azusa; Watanabe, Hiroshi; Maeda, Hiroshi; Otagiri, Masaki; Maruyama, Toru

doi:10.1016/j.jconrel.2015.08.036

Cited by 48 publications

(25 citation statements)

References 21 publications

(27 reference statements)

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“…Liposomes are multilamellar or unilamellar phospholipidic submicroscopic vesicles allowing incorporation of hydrophilic and lipophilic drug due to their special properties (Rengan et al, 2015;Zhang et al, 2018). Biocompatible liposome can accumulate in tumor tissue via the enhanced permeability and retention (EPR) effect (Boyd, Galle, Daglas, Rosenfeld, & Medcalf, 2015;Kinoshita et al, 2015;Theek et al, 2016). However, liposomes are unstable under over oxidized environment because the phospholipid is easy to be oxidized.…”

mentioning

confidence: 99%

Retracted: Ultrasound‐triggered breast tumor sonodynamic therapy through hematoporphyrin monomethyl ether‐loaded liposome

Zhang

Guo

et al. 2019

J Biomed Mater Res

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Sonodynamic therapy (SDT) which employs ultrasound‐triggered sonosensitizers to generate reactive oxygen species (ROS) has been proved to be effective for treatment of cancers. However, it is still desirable for sonosensitizers to be delivered to tumors as effectively as possible. In this study, we prepared the hematoporphyrin monomethyl ether (HMME)‐loaded liposome as the sonosensitizers for SDT and evaluated their effects on human MCF‐7 breast cancer cells in vitro and in vivo. Liposomes prepared by thin film hydration technique were about 100 nm in size with positive zeta potential and exhibited spherical in shape. Following irradiation of ultrasound which generates intracellular ROS, the liposome facilitated the delivery of HMME to tumor cells. HMME‐loaded liposomes showed low cytotoxicity under basal condition but significant sonodynamic effects under ultrasonic irradiation. Notably, HMME‐loaded liposomes exhibited spatial distribution of HMME in tumor tissues of mice. The promoted delivery of HMME into the tumors by liposomes was shown by the greater tumor growth inhibition than free HMME after 20‐day treatment. Taken together, these results show that HMME‐loaded liposome functions as a promising sonosensitizer for SDT, implying the efficient antitumor effects of HMME‐based SDT on breast tumor.

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mentioning

confidence: 99%

Retracted: Ultrasound‐triggered breast tumor sonodynamic therapy through hematoporphyrin monomethyl ether‐loaded liposome

Zhang

Guo

et al. 2019

J Biomed Mater Res

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“…The EPR effect was augmented by the S-nitrosated albumin dimer; therefore, the S-nitrosated albumin dimer and macromolecular anti-tumor drugs ( e.g. micelles and liposomes) were intravenously injected into the tumor-bearing mice together 164 . In vivo imaging with fluorescent micelles revealed enhanced fluorescence intensity in the mice injected with both S-nitrosated albumin dimer and micelles compared with that in the mice injected with only micelles.…”

Section: Albumin As a Scaffold For Modification And Further Biomedicamentioning

confidence: 99%

Strategies for Preparing Albumin-based Nanoparticles for Multifunctional Bioimaging and Drug Delivery

2017

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Biosafety is the primary concern in clinical translation of nanomedicine. As an intrinsic ingredient of human blood without immunogenicity and encouraged by its successful clinical application in Abraxane, albumin has been regarded as a promising material to produce nanoparticles for bioimaging and drug delivery. The strategies for synthesizing albumin-based nanoparticles could be generally categorized into five classes: template, nanocarrier, scaffold, stabilizer and albumin-polymer conjugate. This review introduces approaches utilizing albumin in the preparation of nanoparticles and thereby provides scientists with knowledge of goal-driven design on albumin-based nanomedicine.

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“…From the results of the in vivo antitumor study, they found that the antitumor activity of the NO-HSA dimer was at least 10 times higher than that of NO-HSA. Sequentially, Masaki Otagiri and Toru Maruyama's team studied the effects of NO-HSA on the EPR effect for nano-scaled drug delivery systems, such as micelles, liposomes, and albumin nanoparticles [147,148]. They stated that the improved antitumor effect of the combinative administration of the NO-HSA dimer and nanomedicines should be attributed to the enhancement of the EPR effect by the NO-HSA.…”

Section: Delivery Of No For Targeted Cancer Therapymentioning

confidence: 99%

Nitric Oxide (NO) and NO Synthases (NOS)-Based Targeted Therapy for Colon Cancer

Wang

Xie

et al. 2020

Cancers

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Colorectal cancer (CRC) is one of the most lethal malignancies worldwide and CRC therapy remains unsatisfactory. In recent decades, nitric oxide (NO)—a free-radical gas—plus its endogenous producer NO synthases (NOS), have attracted considerable attention. NO exerts dual effects (pro- and anti-tumor) in cancers. Endogenous levels of NO promote colon neoplasms, whereas exogenously sustained doses lead to cytotoxic functions. Importantly, NO has been implicated as an essential mediator in many signaling pathways in CRC, such as the Wnt/β-catenin and extracellular-signal-regulated kinase (ERK) pathways, which are closely associated with cancer initiation, metastasis, inflammation, and chemo-/radio-resistance. Therefore, NO/NOS have been proposed as promising targets in the regulation of CRC carcinogenesis. Clinically relevant NO-donating agents have been developed for CRC therapy to deliver a high level of NO to tumor sites. Notably, inducible NOS (iNOS) is ubiquitously over-expressed in inflammatory-associated colon cancer. The development of iNOS inhibitors contributes to targeted therapies for CRC with clinical benefits. In this review, we summarize the multifaceted mechanisms of NO-mediated networks in several hallmarks of CRC. We review the clinical manifestation and limitations of NO donors and NOS inhibitors in clinical trials. We also discuss the possible directions of NO/NOS therapies in the immediate future.

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S-Nitrosated human serum albumin dimer as novel nano-EPR enhancer applied to macromolecular anti-tumor drugs such as micelles and liposomes

Cited by 48 publications

References 21 publications

Retracted: Ultrasound‐triggered breast tumor sonodynamic therapy through hematoporphyrin monomethyl ether‐loaded liposome

Retracted: Ultrasound‐triggered breast tumor sonodynamic therapy through hematoporphyrin monomethyl ether‐loaded liposome

Strategies for Preparing Albumin-based Nanoparticles for Multifunctional Bioimaging and Drug Delivery

Nitric Oxide (NO) and NO Synthases (NOS)-Based Targeted Therapy for Colon Cancer

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