Rutin rich <i>Emblica officinalis</i> Geart. fruit extract ameliorates inflammation in the pancreas of rats subjected to alcohol and cerulein administration

Aruna, R; Geetha, A; Suguna, Periyanayagam; Suganya, Vijayashankar

doi:10.1515/jcim-2013-0023

Cited by 15 publications

(5 citation statements)

References 48 publications

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“…Taking buckwheat seeds as an example, the content of rutin is 0.05–1.35% (0.05–1.35 g per 100 g of dry seeds) [ 13 ]. Numerous studies have shown that rutin has anti-oxidant, anti-inflammatory, neuroprotective, nephroprotective, and hepatoprotective effects [ 14 , 15 , 16 , 17 ]. The mutual effects of oxidative damage, inflammation, and hyperglycemia are the main causes of delayed wound healing.…”

Section: Introductionmentioning

confidence: 99%

Effects of Rutin on Wound Healing in Hyperglycemic Rats

et al. 2020

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Long-term poor glycemic control negatively affects macrovascular and microvascular diseases, as well as wound restoration. Buckwheat is a good source of rutin (quercetin-3-O-rutoside) and has benefits in regulating blood sugar. This study was to evaluate the antioxidant and anti-inflammatory effects of rutin on wound healing in streptozotocin-induced hyperglycemic rats. Eighteen male Wistar rats were randomly divided into three groups: normal (NDM), hyperglycemic (DM), and hyperglycemic with rutin (DMR). After induction of hyperglycemia for 2 days, a 15 × 15 mm wound was induced on the back of each rat. Intraperitoneal injection of rutin significantly ameliorated diabetes-induced body weight loss and improved metabolic dysfunctions of hyperglycemic rats. Based on appearance and histopathological staining, rutin promotes wound healing and inhibits production of inflammatory cells. The immunoblotting data indicated that rutin promotes production of antioxidant enzymes induced by nuclear factor erythroid 2-related factor 2 (NRF2), inhibits the expression of matrix metalloproteinases (MMPs) regulated by NF-κB, and decreases the expression of vascular endothelial growth factor (VEGF). It also promotes the expression of neurogenic-related protein (UCH-L1). The aforementioned results indicated that rutin reduces oxidative stress and inflammatory response in hyperglycemic rats, promoting wound healing and subsequently reducing the risk of wound ulcers.

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Section: Introductionmentioning

confidence: 99%

Effects of Rutin on Wound Healing in Hyperglycemic Rats

et al. 2020

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“…Rutin is a common food flavonoid belonging to the f lavonols. Studies have demonstrated that f lavonoid compounds have anti-inflammatory, antioxidant, antitumor, antiviral, anticardiovascular disease and immunomodulatory effects (14)(15)(16). Each phenyl ring of flavonoid compounds can be connected to a hydroxy group, sugar group or substituent group, including polysaccharides and, as the types and connection positions of the sugar are different, various flavonoid glycosides may be formed (17).…”

Section: Introductionmentioning

confidence: 99%

Effect of rutin on spinal cord injury through inhibition of the expression of MIP-2 and activation of MMP-9, and downregulation of Akt phosphorylation

Zhang

2015

Molecular Medicine Reports

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Rutin has extensive pharmacological activities, including antibacterial and anti-inflammatory activities, cooling of the blood to inhibit bleeding, reducing capillary wall fragility and anti-influenza activities. However, whether rutin can ameliorate neuropathic function in spinal cord injury (SCI) in constriction-induced peripheral nerve injury remains to be elucidated. In the present study, the potential protective effects of rutin on SCI rats were investigated. Neurological function was examined using the Basso, Beattie and Bresnahan (BBB) scoring system and by measuring the water content of the spinal cord tissue in SCI rats. SCI-induced programmed cell death was measured using hematoxylin and eosin staining. In addition, the expression of macrophage inflammatory protein-2 (MIP-2) and the activation of matrix metalloproteinase-9 (MMP-9) in the SCI rats were evaluated using ELISA assay kits and zymographic analysis, respectively. The phosphorylation of protein kinase B (p-Akt) was analyzed using a western blot assay. The results demonstrated that administrating rutin began to increase BBB scores and attenuate the spinal cord water content of the SCI rats. Administrating rutin prevented SCI-induced programmed cell death. The SCI rats of in the rutin-treated group were found to exhibit lower expression levels of MIP-2 and p-Akt, reduced MMP-9 activation, compared with the SCI model rats. In conclusion, rutin was demonstrated as a potential protective agent in SCI and enhances the neurotrophic effect by inhibiting the expression of MIP-2 and activation of MMP-9, and downregulating the expression of p-Akt.

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“… 16 The rutin in PEL, which is a flavonoid, is known for its anti-inflammatory properties and can provide protective effects to the pancreas. 17 Compounds with a galloyl moiety showed higher antiproliferative activity than the flavonoid and are worth investigating as potential cancer chemopreventive agents. 18 Ascorbic acid (vitamin C), which is abundantly present in PEL fruit, has the potential to shelter the body from oxidative cascades leading to inflammatory injury.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory Effects ofPhyllanthus emblicaL on Benzopyrene-Induced Precancerous Lung Lesion by Regulating the IL-1β/miR-101/Lin28B Signaling Pathway

et al. 2016

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Background. Phyllanthus emblica L (PEL), a well-known medical plant, has been used in Asian countries for a long time. Increasing evidence suggests that it can prevent the tumorigenesis of cancer associated with nonresolving inflammation. However, the possible anti-inflammatory mechanism responsible for preventing tumorigenesis of precancerous lung lesions is not well elucidated. Materials and methods. Male A/J mice were randomly divided into 5 groups with 10 mice in each group: (1) blank group (saline), (2) benzo(a)pyrene [B(a)P] group, (3) and (4) B(a)P + PEL (5 g/kg/d, 10 g/kg/d, administered by gavage), (5) B(a)P + celecoxib (30 mg/kg/d, administered by gavage). Nodes on the lung surface were observed and calculated. The levels of macrophage inflammatory protein (MIP-2), tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and IL-1β were detected by enzyme-linked immunosorbent assay (ELISA) kits. Cyclo-oxygenase-2 (COX-2), hypoxia-inducible factor-1 (HIF-α), IL-1β, miR-101, and Lin28B protein levels were evaluated by immunohistochemistry and Western blotting. Results. PEL extract treatment significantly reduced the number of nodes on the lung surface and attenuated B(a)P-induced levels of proinflammatory cytokines MIP-2, TNF-α, IL-6, and IL-1β in lung tissue. The protein expressions of COX-2 and HIF-α were significantly decreased by the treatment of PEL. In addition, both PEL extract and celecoxib markedly upregulate the expression of miR-101 while downregulating IL-1β and Lin28B levels. Conclusion. Our study indicated that treatment with PEL extract can not only protect the lung from inflammatory injury but effectively prevent precancerous lung lesions through regulating the IL-1β/miR-i101/Lin28B signaling pathway.

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Rutin rich Emblica officinalis Geart. fruit extract ameliorates inflammation in the pancreas of rats subjected to alcohol and cerulein administration

Abstract: The rutin rich nature of E. officinalis can be claimed for its anti-inflammatory and pancreato protective effects.

Cited by 15 publications

References 48 publications

Effects of Rutin on Wound Healing in Hyperglycemic Rats

Effects of Rutin on Wound Healing in Hyperglycemic Rats

Effect of rutin on spinal cord injury through inhibition of the expression of MIP-2 and activation of MMP-9, and downregulation of Akt phosphorylation

Anti-inflammatory Effects ofPhyllanthus emblicaL on Benzopyrene-Induced Precancerous Lung Lesion by Regulating the IL-1β/miR-101/Lin28B Signaling Pathway

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