Rutin-casein co-precipitates as potential delivery vehicles for flavonoid rutin

Rashidinejad, Ali; Loveday, Simon M.; Jameson, Geoffrey B.; Hindmarsh, Jason P.; Singh, Harjinder

doi:10.1016/j.foodhyd.2019.05.032

Cited by 31 publications

(48 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In another study, rutin was coated with sodium caseinate and trehalose complex, and an analysis revealed that rutin was amorphous after addition of trehalose and pH adjustment. The powder produced by co-precipitation with sodium caseinate contained large amounts of rutin [ 185 ]. Ghayour et al [ 186 ] encapsulated curcumin and quercetin using the coating method.…”

Section: Nanoformulations For Loading and Delivery Of Polyphenolsmentioning

confidence: 99%

Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols

et al. 2020

View full text Add to dashboard Cite

Polyphenols are micronutrients that are widely present in human daily diets. Numerous studies have demonstrated their potential as antioxidants and anti-inflammatory agents, and for cancer prevention, heart protection and the treatment of neurodegenerative diseases. However, due to their vulnerability to environmental conditions and low bioavailability, their application in the food and medical fields is greatly limited. Nanoformulations, as excellent drug delivery systems, can overcome these limitations and maximize the pharmacological effects of polyphenols. In this review, we summarize the biological activities of polyphenols, together with systems for their delivery, including phospholipid complexes, lipid-based nanoparticles, protein-based nanoparticles, niosomes, polymers, micelles, emulsions and metal nanoparticles. The application of polyphenol nanoparticles in food and medicine is also discussed. Although loading into nanoparticles solves the main limitation to application of polyphenolic compounds, there are some concerns about their toxicological safety after entry into the human body. It is therefore necessary to conduct toxicity studies and residue analysis on the carrier.

show abstract

Section: Nanoformulations For Loading and Delivery Of Polyphenolsmentioning

confidence: 99%

Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The encapsulation efficiency (EE) and loading capacity (LC) of composite nanoparticles were estimated using the highperformance liquid chromatography (HPLC) (Rashidinejad et al, 2019). Initially, accurately weighted sample powders were re-dispersed in methanol and then followed 30 min of ultrasonic processing for complete dissolution.…”

Section: Quercetin Encapsulation Efficiency (Ee) and Loading Capacitymentioning

confidence: 99%

Carriers Based on Zein-Dextran Sulfate Sodium Binary Complex for the Sustained Delivery of Quercetin

Wang

Chen

et al. 2020

Front. Chem.

View full text Add to dashboard Cite

Herein, a self-assembly formulation of Zein and dextran sulfate sodium (DSS) binary complex has been developed for the quercetin (Que) delivery. The prepared particles display a smooth sphere in the range of 180 ∼ 250 nm. The addition of DSS shields the Trp residues of Zein that were located on the hydrophilic exterior and in-turn reduces the surface hydrophobicity of the nanoparticles. The presence of DSS, indeed, increases the encapsulation efficiency of Que from the initial 45.9 in the Zein to 72.6% in the Zein/DSS binary complex. A significant reduction of Que diffusion in the simulated intestinal conditions has been observed with the addition of DSS on the nanoparticles, which also improves Que bioavailability. The release mechanism of Que-loaded Zein/DSS composites is in accordance with the Higuchi model (Q = 0.0913t 0.5 +0.1652, R 2 = 0.953). Overall, nanoparticles based on Zein-DSS complexes stand out as an attractive carrier system of quercetin and the outcome could be extended to several bioactive compounds.

show abstract

“…[1] Casein is a conglomerate of four proteins identified as α-casein (α s-1 and α s-2 ), β-casein and ĸ-casein, all of which have similar molecular weights of approximately 24 kDa but differ in their amino acid sequences and in their interactions with hydrophobic and hydrophilic substances . [2,3] Since 2014, casein has been proposed as a raw material for the formation of micro and nano capsules because of its high affinity for hydrophobic substances and is Generally Recognized as Safe (GRAS) substance [4] .Casein has been used to encapsulate different substances in the food industry. Examples of lipophilic organic substances include: omega-3 fatty acids, [5] β-carotene, [1,6,7] fish oil, [8] curcumin, [9][10][11][12] vitamin A, vitamin D, [13,14] , vanillin, [15] eugenol, [16] triclosan, [17] thymol, [18] celecoxib, [19] emodin, [20] sunflower oil, [21] resveratrol, [22,23] hydroxycamptothecin, [24] quercetin, [9] blueberry anthocyanins, [2] naringenin, [25] isoflavone, [25] rutin [4] and linoleic acid [26] ; and hydrophilic organic substances such as: vitamin C [27] and phenolic compounds .…”

Section: Introductionmentioning

confidence: 99%

“…[2,3] Since 2014, casein has been proposed as a raw material for the formation of micro and nano capsules because of its high affinity for hydrophobic substances and is Generally Recognized as Safe (GRAS) substance [4] .Casein has been used to encapsulate different substances in the food industry. Examples of lipophilic organic substances include: omega-3 fatty acids, [5] β-carotene, [1,6,7] fish oil, [8] curcumin, [9][10][11][12] vitamin A, vitamin D, [13,14] , vanillin, [15] eugenol, [16] triclosan, [17] thymol, [18] celecoxib, [19] emodin, [20] sunflower oil, [21] resveratrol, [22,23] hydroxycamptothecin, [24] quercetin, [9] blueberry anthocyanins, [2] naringenin, [25] isoflavone, [25] rutin [4] and linoleic acid [26] ; and hydrophilic organic substances such as: vitamin C [27] and phenolic compounds . [28] On the other hand, nanoparticles of inorganic substances have been encapsulated using caseins, such as iron oxide, [29] calcium carbonate, [30] zinc oxide, [31] silver, gold and copper(II) oxide .…”

Section: Introductionmentioning

confidence: 99%

Properties of micro and nano casein capsules used to protect the active components: A review

Acuña-Avila

Cortés‐Camargo

Jimenez-Rosales

2021

International Journal of Food Properties

View full text Add to dashboard Cite

Casein is an abundant, cheap, and easy to modify milk protein, which is useful as a wall material to encapsulate organic and inorganic substances that can be applied to protect, load, and deliver flavorings, phenolic compounds, drugs, or inorganic substances. There are many reviews that have explored casein itself as well as the configuration of micelle structures to load substances, but there is a lack of condensed information about the physicochemical properties of casein capsules and the factors that influence them, such as the type of casein, core material and the methods used to obtain the capsules and characterize them. The aim of this review was to identify trends among the different types of casein proteins that can be used as wall materials for encapsulation, the type of core substances that are encapsulated, the reported size, the encapsulation efficiency, and the characterization methods. It can be assumed that each modification of the casein micelle such as the type of casein, active substance, the proportion of substance, and methods used to encapsulate can produce different results in terms of size, morphology and stabilization. These characterization plays a key role in understanding the physicochemical properties of casein encapsulates. In this review the factors that affect the encapsulation with casein as wall material and the characterization methods are presented.

show abstract

Rutin-casein co-precipitates as potential delivery vehicles for flavonoid rutin

Cited by 31 publications

References 38 publications

Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols

Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols

Carriers Based on Zein-Dextran Sulfate Sodium Binary Complex for the Sustained Delivery of Quercetin

Properties of micro and nano casein capsules used to protect the active components: A review

Contact Info

Product

Resources

About