Carriers Based on Zein-Dextran Sulfate Sodium Binary Complex for the Sustained Delivery of Quercetin

Wang, Tian-xing; Li, Xiaoxi; Chen, Ling; Li, Lin; Janaswamy, Srinivas

doi:10.3389/fchem.2020.00662

Cited by 17 publications

(8 citation statements)

References 56 publications

(56 reference statements)

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“…Upon encapsulation of quercetin in hollow zein particle, the amide I peak of zein was unchanged, whereas the amide II showed a redshift to 1537, 1543 and 1539 cm −1 in HZ, HZ-chi and HZ-chi/pec particles ( Figure 4 A). These shifts in the amide II result from hydrophobic, electrostatic and hydrogen bonding of quercetin with wall materials [ 46 , 47 ].…”

Section: Resultsmentioning

confidence: 99%

Improving Physicochemical Stability of Quercetin-Loaded Hollow Zein Particles with Chitosan/Pectin Complex Coating

et al. 2021

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Hollow nanoparticles are preferred over solid ones for their high loading capabilities, sustained release and low density. Hollow zein particles are susceptible to aggregation with a slight variation in the ionic strength, pH and temperature of the medium. This study was aimed to fabricate quercetin-loaded hollow zein particles with chitosan and pectin coating to improve their physicochemical stability. Quercetin as a model flavonoid had a loading efficiency and capacity of about 86–94% and 2.22–5.89%, respectively. Infrared and X-ray diffraction investigations revealed the interaction of quercetin with zein and the change in its physical state from crystalline to amorphous upon incorporation in the composite particles. The chitosan/pectin coating improved the stability of quercetin-loaded hollow zein particles against heat treatment, sodium chloride and in a wide range of pH. The complex coating protected quercetin that was encapsulated in hollow zein particles from free radicals in the aqueous medium and enhanced its DPPH radical scavenging ability. The entrapment of quercetin in the particles improved its storage and photochemical stability. The storage stability of entrapped quercetin was enhanced both at 25 and 45 °C in hollow zein particles coated with chitosan and pectin. Therefore, composite hollow zein particles fabricated with a combination of polysaccharides can expand their role in the encapsulation, protection and delivery of bioactive components.

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Section: Resultsmentioning

confidence: 99%

Improving Physicochemical Stability of Quercetin-Loaded Hollow Zein Particles with Chitosan/Pectin Complex Coating

et al. 2021

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“…In one of these studies, Wang et al developed zein and dextran sulfate sodium binary complex to deliver quercetin. This nanovehicle exhibited almost no toxicity, as well as a sustained released, making it a promising candidate for future applications [104]. In another study, Lozano-Pérez et al synthesized silk fibroin nanoparticles loaded with quercetin and observed a controlled released under the conditions of pH characteristic of intestinal fluid, which makes them suitable for gastrointestinal delivery [105].…”

Section: Biopolymeric Nanoparticlesmentioning

confidence: 98%

Nanotechnology Innovations to Enhance the Therapeutic Efficacy of Quercetin

Pinheiro

Neves

2021

Nanomaterials

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Quercetin is a flavonol present in many vegetables and fruits. Generally, quercetin can be found in aglycone and glycoside forms, mainly in leaves. The absorption of this compound occurs in the large and small intestine, where it suffers glucuronidation, sulfidation, and methylation to improve hydrophilicity. After metabolization, which occurs mainly in the gut, it is distributed throughout the whole organism and is excreted by feces, urine, and exhalation of carbon dioxide. Despite its in vitro cytotoxicity effects, in vivo studies with animal models ensure its safety. This compound can protect against cancer, cardiovascular diseases, chronic inflammation, oxidative stress, and neurodegenerative diseases due to its radical scavenging and anti-inflammatory properties. However, its poor bioavailability dampens the potential beneficial effects of this flavonoid. In that sense, many types of nanocarriers have been developed to improve quercetin solubility, as well as to design tissue-specific delivery systems. All these studies manage to improve the bioavailability of quercetin, allowing it to increase its concentration in the desired places. Collectively, quercetin can become a promising compound if nanotechnology is employed as a tool to enhance its therapeutic efficacy.

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“…It was reported that free quercetin inhibited melanoma cell migration and invasion in vitro [54]. Furthermore, data suggest that quercetin encapsulation improves its bioavailability and stability [21,55,56]. Therefore, this flavonoid is a valuable compound that could be used in melanoma treatment.…”

Section: Flavonoidsmentioning

confidence: 99%

Drug Delivery Systems and Flavonoids: Current Knowledge in Melanoma Treatment and Future Perspectives

2022

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Melanoma is an aggressive form of skin cancer with a high prevalence in the population. An early diagnosis is crucial to cure this disease. Still, when this is not possible, combining potent pharmacological agents and effective drug delivery systems is essential to achieve optimal treatment and improve patients’ quality of life. Nanotechnology application in biomedical sciences to encapsulate anticancer drugs, including flavonoids, in order to enhance therapeutic efficacy has attracted particular interest. Flavonoids have shown effectiveness against various types of cancers including in melanoma, but they show low aqueous solubility, low stability and very poor oral bioavailability. The utilization of novel drug delivery systems could increase flavonoid bioavailability, thereby potentiating its antitumor effects in melanoma. This review summarizes the potential of different flavonoids in melanoma treatment and the several nanosystems used to improve their biological activity, considering published information that reported improved biological and pharmacological properties of encapsulated flavonoids.

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Carriers Based on Zein-Dextran Sulfate Sodium Binary Complex for the Sustained Delivery of Quercetin

Cited by 17 publications

References 56 publications

Improving Physicochemical Stability of Quercetin-Loaded Hollow Zein Particles with Chitosan/Pectin Complex Coating

Improving Physicochemical Stability of Quercetin-Loaded Hollow Zein Particles with Chitosan/Pectin Complex Coating

Nanotechnology Innovations to Enhance the Therapeutic Efficacy of Quercetin

Drug Delivery Systems and Flavonoids: Current Knowledge in Melanoma Treatment and Future Perspectives

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