Improving Physicochemical Stability of Quercetin-Loaded Hollow Zein Particles with Chitosan/Pectin Complex Coating

Khan, Muhammad Aslam; Zhou, Chufan; Zheng, Pu; Zhao, Meng; Liang, Li

doi:10.3390/antiox10091476

Cited by 16 publications

(8 citation statements)

References 65 publications

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“…Additionally, both blends show a stronger peak at around 3°. Peaks at these low angles have been attributed to helical secondary structures, as well as other higher hierarchical assemblies by other authors [ 52 , 53 , 54 ].…”

Section: Resultsmentioning

confidence: 66%

Preparation and Characterization of Electrospun Polysaccharide FucoPol-Based Nanofiber Systems

et al. 2022

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The electrospinnability of FucoPol, a bacterial exopolysaccharide, is presented for the first time, evaluated alone and in combination with other polymers, such as polyethylene oxide (PEO) and pullulan. The obtained fibers were characterized in terms of their morphological, structural and thermal properties. Pure FucoPol fibers could not be obtained due to FucoPol’s low water solubility and a lack of molecular entanglements. Nanofibers were obtained via blending with PEO and pullulan. FucoPol:PEO (1:3 w/w) showed fibers with well-defined cylindrical structure, since the higher molecular weight of PEO helps the continuity of the erupted jet towards the collector, forming stable fibers. WAXS, DSC and TGA showed that FucoPol is an amorphous biopolymer, stable until 220 °C, whereas FucoPol-PEO fibers were stable until 140 °C, and FucoPol:pullulan fibers were stable until 130 °C. Interestingly, blended components influenced one another in intermolecular order, since new peaks associated to intermolecular hierarchical assemblies were seen by WAXS. These results make FucoPol-based systems viable candidates for production of nanofibers for packaging, agriculture, biomedicine, pharmacy and cosmetic applications.

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Section: Resultsmentioning

confidence: 66%

Preparation and Characterization of Electrospun Polysaccharide FucoPol-Based Nanofiber Systems

et al. 2022

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“…27 It indicates that different temperatures and media have a great impact on the stability of nanoparticles. 28 3.2. Cellular Uptake and Cochlear Distribution.…”

Section: Resultsmentioning

confidence: 99%

“…However, although their particle size was almost unchanged in AP at 37 °C, the PDI of CUR-PLGA NPs increased with time, indicating that CUR-CS/PLGA NPs were more stable than CUR-PLGA NPs for the reason that CS could enhance the stability of NPs . It indicates that different temperatures and media have a great impact on the stability of nanoparticles …”

Section: Resultsmentioning

confidence: 99%

Curcumin-Encapsulated Chitosan-Coated Nanoformulation as an Improved Otoprotective Strategy for Ototoxic Hearing Loss

et al. 2022

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Overexpression of apoptotic factors in the inner ear is generally proven to induce ototoxicity. This has aroused research interest in various antiapoptotic drugs, the most representative of which is curcumin (CUR). In this study, two nanoformulations of CUR were developed with sustained-release behavior to improve their protective effects against ototoxic hearing loss (HL), which were the nanoparticles of CUR-loaded poly(lactic acid–glycolic acid) (CUR-PLGA NPs) and CUR-loaded chitosan-coated PLGA NPs (CUR-CS/PLGA NPs). The obtained results revealed that both CUR-NPs provided otoprotection in vitro and in vivo, and their effective doses in guinea pigs were much less than that of dexamethasone, which was clinically used to treat HL. Moreover, relative to CUR and CUR-PLGA NPs, CUR-CS/PLGA NPs exhibited the highest accumulation in HEI-OC1 cells and guinea pigs’ cochlea. In pharmacodynamic experiments, the optimal administration timing was investigated, and CUR-CS/PLGA NPs showed sustained efficacy and the best hearing improvement at all tested sound frequencies. Lastly, the protective effect of CUR nanoformulations was further validated via inhibition of Caspase-3 and Bax activation, thereby reducing the concentration of reactive oxygen species and protecting mitochondrial integrity in hair cells. Collectively, CUR-CS/PLGA NPs demonstrated potent and lasting effects against ototoxic HL, making our novel formulation a promising candidate for the alleviation of sensorineural HL.

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“…Natural polysaccharides are considered to be effective stabilizers for zein carriers, such as gum, xanthan gum, and alginate. Muhammad et al [ 26 ] used a zein–pectin carrier to load quercetin, which improved the thermal stability and photostability of quercetin. However, the high viscosity and low charge density of some polysaccharides limit their application [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Rutin–Loaded Zein–Carboxymethyl Starch Nanoparticles

Chen

McClements

et al. 2022

Foods

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In this work, rutin (RT)–loaded zein–carboxymethyl starch (CMS) nanoparticles were successfully prepared by the antisolvent precipitation method. The effect of CMS on composite nanoparticles at different concentrations was studied. When the ratio of zein–RT–CMS was 10:1:30, the encapsulation efficiency (EE) was the highest, reaching 73.5%. At this ratio, the size of the composite nanoparticles was 196.47 nm, and the PDI was 0.13, showing excellent dispersibility. The results of fluorescence spectroscopy, FTIR, XRD, and CD showed that electrostatic interaction, hydrogen bonding, and hydrophobic interaction were the main driving forces for the formation of nanoparticles. It can be seen from the FE–SEM images that the zein–RT–CMS nanoparticles were spherical. With the increase in the CMS concentration, the particles gradually embedded in the cross–linked network of CMS (10:1:50). After RT was loaded on zein–CMS nanoparticles, the thermal stability and pH stability of RT were improved. The results showed that zein–CMS was an excellent encapsulation material for bioactive substances.

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Improving Physicochemical Stability of Quercetin-Loaded Hollow Zein Particles with Chitosan/Pectin Complex Coating

Cited by 16 publications

References 65 publications

Preparation and Characterization of Electrospun Polysaccharide FucoPol-Based Nanofiber Systems

Preparation and Characterization of Electrospun Polysaccharide FucoPol-Based Nanofiber Systems

Curcumin-Encapsulated Chitosan-Coated Nanoformulation as an Improved Otoprotective Strategy for Ototoxic Hearing Loss

Preparation and Characterization of Rutin–Loaded Zein–Carboxymethyl Starch Nanoparticles

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