Rutin attenuates neuroinflammation in spinal cord injury rats

Jiang, Wu; Li, Maoqiang; He, Fangping; Bian, Zhenyu; Qifang, He; Wang, Xuepeng; Zhu, Liangliang

doi:10.1016/j.jss.2016.02.041

Cited by 41 publications

(33 citation statements)

References 40 publications

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“…The flavonol glycoside, rutin ( 22 ), its aglycone quercetin, and a related glycoside isoquercetin (quercetin 3- O -glucoside) have been shown to possess neuroprotective effects on glutamate-induced oxidative injury in the HT22 hippocampal cells [ 198 , 199 ]. Rutin ( 22 ) reportedly reduces the levels of ROS, MDA, NLRP3 (NLR family pyrin domain containing 3), ASC (apoptosis-associated speck-like protein containing a CARD), caspase-1, IL-1 β , and IL-18 and attenuates histologic alteration as well as improving locomotion recovery [ 200 ]. Quercetin also dose-dependently reduced the A β - (A β (1–42) -) induced paralysis in Caenorhabditis elegans by decreasing the amount of aggregated proteins [ 201 ] and antagonized the high glucose-induced damage of Schwann cells by inducing autophagy [ 202 ].…”

Section: Classical Examples Of Neuroprotective Drugs Of Plant-origmentioning

confidence: 99%

Plants‐Derived Neuroprotective Agents: Cutting the Cycle of Cell Death through Multiple Mechanisms

Elufioye

Berida

Habtemariam

2017

Evidence-Based Complementary and Alternative Medicine

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Neuroprotection is the preservation of the structure and function of neurons from insults arising from cellular injuries induced by a variety of agents or neurodegenerative diseases (NDs). The various NDs including Alzheimer's, Parkinson's, and Huntington's diseases as well as amyotropic lateral sclerosis affect millions of people around the world with the main risk factor being advancing age. Each of these diseases affects specific neurons and/or regions in the brain and involves characteristic pathological and molecular features. Hence, several in vitro and in vivo study models specific to each disease have been employed to study NDs with the aim of understanding their underlying mechanisms and identifying new therapeutic strategies. Of the most prevalent drug development efforts employed in the past few decades, mechanisms implicated in the accumulation of protein-based deposits, oxidative stress, neuroinflammation, and certain neurotransmitter deficits such as acetylcholine and dopamine have been scrutinized in great detail. In this review, we presented classical examples of plant-derived neuroprotective agents by highlighting their structural class and specific mechanisms of action. Many of these natural products that have shown therapeutic efficacies appear to be working through the above-mentioned key multiple mechanisms of action.

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Section: Classical Examples Of Neuroprotective Drugs Of Plant-origmentioning

confidence: 99%

Plants‐Derived Neuroprotective Agents: Cutting the Cycle of Cell Death through Multiple Mechanisms

Elufioye

Berida

Habtemariam

2017

Evidence-Based Complementary and Alternative Medicine

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“…Studies showed that rutin control oxidative stress by inhibition of NLRP3 oxidant activation in a rat model of SCI (Wu et al, 2016;Schroder and Tschopp, 2010). This indicates that the activation of the Protein 38 mitogen-activated protein kinase/inducible nitric oxide synthase (p38MAPK/iNOS)signaling pathway is involved in the secondary injury mechanism post-SCI (Lawrence et al, 2008),quercetin can regulate secondary oxidative stress following SCI by directly clearing oxidants and inhibiting activation of thep38MAPK/iNOS pathway in SCI rats (Wu et al, 2016). In another study, investigators treated mixed neuronal/glial cell cultures with Silymarin.…”

Section: Anti-oxidative Propertiesmentioning

confidence: 99%

Therapeutic potential of flavonoids in spinal cord injury

Zhang

Hölscher

2017

Reviews in the Neurosciences

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AbstractSpinal cord injury (SCI) is a catastrophic event that can profoundly affect a patient’s life, with far-reaching social and economic effects. A consequential sequence of SCI is the significant neurological or psychological deficit, which obviously contributes to the overall burden of this condition. To date, there is no effective treatment for SCI. Therefore, developing novel therapeutic strategies for SCI is highly prioritized. Flavonoids, one of the most numerous and ubiquitous groups of plant metabolites, are the active ingredients of traditional Chinese medicine such as Scutellaria baicalensis Georgi (Huang Qin) or Ginkgo biloba (Ying Xin). Accumulated research data show that flavonoids possess a range of key pharmacological properties such as anti-inflammatory, anti-oxidant, anti-tumor, anti-viral, anti-cardiovascular disease, immunomodulatory, and neuroprotective effects. Based on this, the flavonoids show therapeutic potential for SCI diseases. In this paper, we will review the pharmacological properties of different types of flavonoids for the treatment of SCI diseases, and potential underlying biochemical mechanisms of action will also be described.

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“…The models described in the literature use spinal cord compression with forceps or vascular clips for some time. In particular, the holding of such clips for one minute in rats is sufficient to induce them paraplegia [41][42][43]. The main advantages of this method is the simplicity and reliability of an injury.…”

Section: Different Variants Of Spinal Cord Compression and Contusionmentioning

confidence: 99%

In vivo and in vitro models of traumatic injuries of the spinal cord

Rybachuk¹,

Arkhypchuk²,

Lazarenko³

2017

JCOT

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In recent years, there is a growing interest in the mechanisms of regeneration of damaged nerve tissue, including the spinal cord, as its injuries are quite common due to traffic accidents, industrial injuries and military actions. Damage to the spinal cord results in the loss of functional activity of the body below the injury site, which affects person’s ability to self-service and significantly reduces its efficiency. The effects of spinal injuries annually cause significant social and economic losses worldwide, including Ukraine. The development of new treatments for pathologies of the central nervous system requires mandatory pre-testing of their effectiveness in experiments in vitro and in vivo. Therefore, searching and creation of optimal animal model of spinal cord injury is in order to it meets most complete picture of the damage characteristic of real conditions in humans. This is an important task of modern neurophysiology. Such models can be used, primarily, for a more detailed clarification of the pathogenesis of all levels of nerve tissue damage and research of its own recovery potential by endogenous reparation mechanisms. In addition, experimental models allow to estimate the safety and predict the effectiveness of various therapeutic approaches to spinal cord injury.

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Rutin attenuates neuroinflammation in spinal cord injury rats

Cited by 41 publications

References 40 publications

Plants‐Derived Neuroprotective Agents: Cutting the Cycle of Cell Death through Multiple Mechanisms

Plants‐Derived Neuroprotective Agents: Cutting the Cycle of Cell Death through Multiple Mechanisms

Therapeutic potential of flavonoids in spinal cord injury

In vivo and in vitro models of traumatic injuries of the spinal cord

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