Ruthenium(II) Complex of Hbopip:  Synthesis, Characterization, pH-Induced Luminescence “Off−On−Off” Switch, and Avid Binding to DNA

Han, Mei-Jiao; Gao, Lihua; Lu, Yuanyuan; Wang, Kezhi

doi:10.1021/jp0548570

Cited by 105 publications

(58 citation statements)

References 67 publications

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“…The observed change of melting temperatures (DT m ) in the presence of complexes 1 and 2 are shown in Table 2. The increases in T m of the Ru(II) complex (the DT m is 6.0°C for 1, and 9.4°C for 2, respectively) are comparable to those observed for classical intercalators [45][46][47][48]. The large change in the T m of CT-DNA in the presence of complexes suggests an intercalative binding of the complexes to DNA and the binding affinities of both complexes with DNA are very strong.…”

Section: Thermal Denaturation Studysupporting

confidence: 61%

Synthesis and DNA interaction studies of ruthenium(II) complexes with isatino[1, 2-b]-1,4,8,9-tetraazatriphenylene as an intercalative ligand

Liu

Zeng

2009

Transition Met Chem

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The binding of the ruthenium(II) complexes [Ru(bpy) 2 (ITAP)](ClO 4 ) 2 (bpy = 2,2'-bipyridine) and [Ru(phen) 2 (ITAP)](ClO 4 ) 2 (phen = 1,10-phenanthroline, ,4,8,9-tetraazatriphenylene) to calf thymus DNA (CT-DNA) have been investigated with UVvisible and emission spectroscopy, viscosity measurements, thermal denaturation, and photoactivated cleavage. The experimental results indicate that the two complexes bind to CT-DNA through an intercalative mode. The two Ru(II) complexes in the presence of plasmid pBR322 DNA have been found to give rise to nicking of DNA upon irradiation.

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Section: Thermal Denaturation Studysupporting

confidence: 61%

Synthesis and DNA interaction studies of ruthenium(II) complexes with isatino[1, 2-b]-1,4,8,9-tetraazatriphenylene as an intercalative ligand

Liu

Zeng

2009

Transition Met Chem

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“…The first ionization constant of the protonated piperazine ring is comparable to the corresponding pK a value of 1.50 for the complex 1a [38]. The ionization constant of the protonated imidazole rings is close to the pK a2 value of 5.23 for the complex [Ru(bpy) 2 (Hbopip)] 2+ [39]. The ionization constant of the neutral imidazole rings is comparable to the corresponding value of 9.28 for the complex [(bpy) 2 Ru(mbpibH 2 )Ru(bpy) 2 ] 4+ [40].…”

Section: Ph-dependent Photophysical Propertiessupporting

confidence: 52%

Preparation, Characterization, and Proton-induced Fluorescence Switching of Two Ru(II) Polypyridyl Complexes containing Different N-Heterocyclic Groups

Cheng

Chen

Wang

et al. 2012

Zeitschrift Für Naturforschung B

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Two ligands H 2 L 1 and HL 2 containing imidazole rings and piperazine or morpholine units have been prepared by the reaction of 1,10-phenanthroline-5,6-dione with 4,4'-(1,4-piperazinediyl)bisbenzaldehyde and 4-morpholinobenzaldehyde, respectively. The Ru(II) polypyridyl complexes [(bpy) 2 Ru(H 2 L 1 )Ru(bpy) 2 ] 4+ and [(bpy) 2 Ru(HL 2 )] 2+ have been synthesized by the reaction of Ru(bpy) 2 Cl 2 ·2H 2 O with ligands H 2 L 1 and HL 2 , respectively. The pH effects on the UV/Vis absorption and fluorescence spectra of both complexes have been studied. The ground-state and excited-state ionization constants of the acid-base equilibria have been calculated according to the absorbance and emission data. The photophysical properties of both complexes are strongly dependent on the solution pH. They act as proton-induced "off-on-off" fluorescence pH sensors through protonation and deprotonation of the imidazole, piperazine or morpholine groups, with a maximum on-off ratio of 6 in buffer solution at room temperature.

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“…The observed melting temperatures in the presence of complex were 79.0±1 to those observed for classical intercalator, [43] suggesting the large DNA-binding affinity of the complexes.…”

Section: Dna Melting Experimentsmentioning

confidence: 75%

DNA interaction, free radical scavenging andin‐vitroantibacterial activity of drug‐based copper(II) complexes

Patel

Dosi

Bhatt

2011

Applied Organom Chemis

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The Cu(II) complexes of type [Cu(cpf)(A n )Cl] (A n = terpyridines, cpf = ciprofloxacin) were synthesized and characterized using IR, mass and reflectance spectra. The free ligands and their complexes were evaluated for their in-vitro antimicrobial activity against a panel of Gram-positive and Gram-negative bacteria. The complexes exhibit better or equal inhibition in comparison to free fluoroquinolones. Binding interactions of the complexes with calf thymus (CT DNA) were investigated by absorption titration, viscosity studies and DNA melting temperature experiment. The cleavage reaction on pUC19 DNA was monitored by agarose gel electrophoresis. The lower concentration of the complexes was catalysed the dismutation of superoxide radical at biological pH, which indicates that the complexes can act as a possible model for superoxide dismutase.

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Ruthenium(II) Complex of Hbopip: Synthesis, Characterization, pH-Induced Luminescence “Off−On−Off” Switch, and Avid Binding to DNA

Cited by 105 publications

References 67 publications

Synthesis and DNA interaction studies of ruthenium(II) complexes with isatino[1, 2-b]-1,4,8,9-tetraazatriphenylene as an intercalative ligand

Synthesis and DNA interaction studies of ruthenium(II) complexes with isatino[1, 2-b]-1,4,8,9-tetraazatriphenylene as an intercalative ligand

Preparation, Characterization, and Proton-induced Fluorescence Switching of Two Ru(II) Polypyridyl Complexes containing Different N-Heterocyclic Groups

DNA interaction, free radical scavenging andin‐vitroantibacterial activity of drug‐based copper(II) complexes

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