Synthesis and DNA interaction studies of ruthenium(II) complexes with isatino[1, 2-b]-1,4,8,9-tetraazatriphenylene as an intercalative ligand

Abstract

The binding of the ruthenium(II) complexes [Ru(bpy) 2 (ITAP)](ClO 4 ) 2 (bpy = 2,2'-bipyridine) and [Ru(phen) 2 (ITAP)](ClO 4 ) 2 (phen = 1,10-phenanthroline, ,4,8,9-tetraazatriphenylene) to calf thymus DNA (CT-DNA) have been investigated with UVvisible and emission spectroscopy, viscosity measurements, thermal denaturation, and photoactivated cleavage. The experimental results indicate that the two complexes bind to CT-DNA through an intercalative mode. The two Ru(II) complexes in the presence of plasmid pBR322 DNA have been found to give rise to nicking of DNA upon irradiation.

Synthesis, Characterization, and DNA Interaction Studies of Dysprosium(III) with Methylene Blue

“…A partial intercalation of ligand may bend (or kink) the DNA helix, resulting in the decrease of the effective length and the viscosity. [24][25][26] The experimental result demonstrates that Dy(III)(MB) 3 can bind to DNA by partial intercalation mode.…”

Ferrocene-Based Bioactive Bimetallic Thiourea Complexes: Synthesis and Spectroscopic Studies

“…Investigations of drug-DNA interactions have great importance in life science [ 25 ]. Interest in understanding the association of drug molecules with duplex DNA has been developed in the hope of understanding the mode of binding [ 26 ]. The noncovalent interactions of a drug with DNA may involve three possible modes of interaction: intercalation, groove binding, and electrostatic interactions [ 27 ].…”

Interaction mode between methylene blue-Sm(III) complex and herring sperm DNA

“…A classical intercalation model demands the space of adjacent base pairs to be large enough to accommodate the bound ligand and elongate the [31]. A partial non-classical intercalation of the complex would reduce the DNA viscosity [32]. The changes in relative viscosity of hsDNA are shown in Figure 10.…”