Ruthenium complexes of ferrocene mannich bases: DNA/BSA interactions and cytotoxicity against A549 cell line

Pulipaka, Ramadevi; Singh, Rajinder; Jana, Sarmita; Devkar, Ranjitsinh; Chakraborty, Debkumar

doi:10.1016/j.jphotochem.2015.02.010

Cited by 35 publications

(13 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The color intensity indirectly reflects the health of cells and functional mitochondria . Because of the simplicity and effectiveness of this protocol MTT assay is widely used for assessing cytotoxicity of various therapeutic agents, metal complexes, and nanoparticles . In our study interaction of ion gel with adherent A549 cells did not account for any mortality till the highest dose (200 μg mL −1 ) (Figure ).…”

Section: Resultsmentioning

confidence: 61%

Preparation of a Noncytotoxic Hemocompatible Ion Gel by Self-Polymerization of HEMA in a Green Deep Eutectic Solvent

Mukesh

Upadhyay

Devkar

et al. 2016

Macromol. Chem. Phys.

View full text Add to dashboard Cite

Self‐polymerization of optimized amount of 2‐hydroxyethylmethacrylate (HEMA) in a natural deep eutectic solvent (NADES) is obtained by the complexation between choline chloride and fructose (ChCl:Fruc. 2:1) in the presence of indomethacin, an anti‐inflammatory drug resulted formation of a drug‐immobilized ion gel. The ion gel thus obtained is found to be stable in gastrointestinal fluid pH (GIF) and sustained release in simulated lower intestinal fluid for 20 h (88% release) at pH 6.8 and 96% release at pH 7.4 for 15 h (colon & blood pH) at physiological human body temperature (37 °C) of the drug is recorded. The drug can be stored in the gel matrices at room temperature for long durations such as 6 months without any degradation. The ion gel of poly‐HEMA obtained in the NADES does not appear to inhibit the growth of mammalian cells in vitro and is found to be compatible to human blood thus implying toward their potential for therapeutic applications as pH‐sensitive hydrophobic drug carrier for oral application as well as in tissue engineering.

show abstract

Section: Resultsmentioning

confidence: 61%

Preparation of a Noncytotoxic Hemocompatible Ion Gel by Self-Polymerization of HEMA in a Green Deep Eutectic Solvent

Mukesh

Upadhyay

Devkar

et al. 2016

Macromol. Chem. Phys.

View full text Add to dashboard Cite

show abstract

“…Chakraborty and colleagues also investigated Ru III ‐Fe II and Ru II ‐Fe II complexes with amino‐ferrocenyl ligands. Their first approach was to synthesize RuL 3 (L = amino‐ferrocene ligand) complexes with various amino acids 74 – 77 (Figure ).…”

Section: Rutheniummentioning

confidence: 99%

“…It is suggested that the lower IC 50 values of 74 – 77 can be attributed to the hypothesis that the Ru III complexes act as prodrugs, which are reduced to the active Ru II species in the hypoxic cancer cell environment. The ruthenium metal centres of complexes 78 – 81 are in the 2+ oxidation state from the beginning, therefore, they are more reactive and less of the compound will reach the intended targets …”

Section: Rutheniummentioning

confidence: 99%

See 1 more Smart Citation

Heterometallic Multinuclear Complexes as Anti‐Cancer Agents‐An Overview of Recent Developments

2019

View full text Add to dashboard Cite

This review provides a critical assessment of the advances made in the development of heterometallic multinuclear complexes as potential chemotherapeutic agents, with the aim of providing a starting point for future investigators. The combination of the classical transition metals (Pt, Ru and Au) with other metal moieties has the potential to result in complexes with improved pharmacokinetic and pharmacodynamic properties. This enables selective targeting of the bio- [a] 3434 Figure 2. The Pt II -Ru III complexes, IT127 and AH-197, [35] and the macrocyclic rectangles investigated by Chi and colleagues. [36] The IC 50 (μM) values reported are shown below the chemical structures.

show abstract

“…Extensive use of chemotherapy for alleviating symptoms and for treating lung cancer also involves undesired physiological effects. In recent times, metal complexes (Singh et al, 2012;Vyas et al, 2013;Vyas et al, 2014;Ramadevi et al, 2015;Thakore et al, 2015), herbal extracts (Sankhari et al, 2012;Patel et al, 2012), structured nano sized particles (Valodkar et al, 2011;Valodkar et al, 2012) or novel proteins from bacterial or fungal origins (Huang et al, 2002) have been extensively researched as a therapeutic option.…”

Section: Introductionmentioning

confidence: 99%

Cyanobacterial phycoerythrin purified from marine <i>Lyngbya</i> sp. induces apoptosis in lung carcinoma cells

Madamwar

Kaushal

Patel

et al. 2015

Bangladesh J Pharmacol

Self Cite

View full text Add to dashboard Cite

Phycoerythrins from various cyanobacterial sources have been extensively studied globally for their therapeutic potentials. This study shows the apoptotic potential of cyanobacterial phycoerythrin isolated, purified and characterized from marine Lyngbya sp. A09DM on human lung carcinoma cells (A549 cell). Results indicated that purified cyanobacterial phycoerythrin accounted for a dose-dependent decrement in cell viability, mitochondrial membrane potential and an increment in lactate dehydrogenase release. Higher dose of cyanobacterial phycoerythrin caused loss of cell viability and nuclear condensation/fragmentation. Flow cytometry accounted for more number of cells in G0/G1 phase and an increase in total number of early apoptotic cells (39.5%). Overall, this study is the first to report on apoptotic property of cyanobacterial phycoerythrin from marine Lyngbya sp. A09DM against A549 human lung carcinoma cells and requires a detailed scrutiny to establish its anti-cancer potential. Article Info

show abstract

Ruthenium complexes of ferrocene mannich bases: DNA/BSA interactions and cytotoxicity against A549 cell line

Cited by 35 publications

References 59 publications

Preparation of a Noncytotoxic Hemocompatible Ion Gel by Self-Polymerization of HEMA in a Green Deep Eutectic Solvent

Preparation of a Noncytotoxic Hemocompatible Ion Gel by Self-Polymerization of HEMA in a Green Deep Eutectic Solvent

Heterometallic Multinuclear Complexes as Anti‐Cancer Agents‐An Overview of Recent Developments

Cyanobacterial phycoerythrin purified from marine <i>Lyngbya</i> sp. induces apoptosis in lung carcinoma cells

Contact Info

Product

Resources

About