Russell body gastritis associated withHelicobacter pyloriinfection: a case report

Abstract

An unusual and rare gastric mucosal lesion histologically consisting of a localised accumulation of Russell bodies and Russell body-containing plasma cells, the so-called Mott cells, has been recognised only recently and termed as “Russell body gastritis”. This lesion, despite its densely monomorphous appearance is easily confirmed to be non-neoplastic by its polyclonal immunoreactive pattern to immunoglobulin light chains. However, the aetiology of Russell body gastritis is controversial and hence the optimal treatment for this disease has not been established. Two cases of Russell body gastritis associated withHelicobacter pyloriinfection are reported, and the possible role ofH pyloriinfection in the pathogenesis is discussed.

Prominent Mott cell proliferation in Epstein-Barr virus-associated gastric carcinoma

“…Another differential diagnosis is Russell body gastritis, which is characterized by Mott cell accumulation in the gastric mucosa associated with H pylori gastritis [5][6][7]. Although both of our cases were positive for H pylori infection, the Mott cell proliferation was limited to within the tumors and was not observed in the background mucosa, eliminating the possibility of Russell body gastritis.…”

Malignant B-Cell Lymphoma with Mott Cell Differentiation in a Ferret (Mustela Putorius Furo)

“…Although the lymphoma in the present study had a densely monomorphous appearance, the Mott cells were considered nonneoplastic because of the polyclonal immunoreactive pattern to immunoglobulin light chains. 19,20 However, in the present case, Mott cells were considered neoplastic because of its monoclonal immunoreactivity to lambda light chain. A previous study 11 reported a Mott cell tumor of the stomach in humans with H. pylori infection and suggested that H. pylori might have influenced the immunological environment and resulted in the formation of Mott cells.…”

Gastric B-Cell Lymphoma with Mott Cell Differentiation in a Dog

“…Despite its monomorphic, plasmacytic appearance, this lesion is not considered neoplastic because of its polyclonal immunoreactivity. 8 In the neoplasm of the present report, the possibility of a similar inflammatory lesion was considered but excluded based on the presence of metastases, the morphologic appearance, and the absence of Helicobacter spp. microorganisms in gastric samples.…”