Prominent Mott cell proliferation in Epstein-Barr virus-associated gastric carcinoma

Reduction of immunity in HIV-infected individuals: Can fibrosis induce hypoplasia in palatine and lingual tonsils of individuals with HIV infection?

“…However, currently it is known that plasma cells are present in chronic inflammatory reactions caused by prolonged antigenic stimulation, as in HIV infection [25][26][27][28]. The reason why these immunoglobulins crystallize in the cytoplasm remains unclear [29,30]. Therefore, in the present study, the lingual and palatine tonsils would be suffering constant antigenic stimulation by HIV, which could be increased by immunoglobulin synthesis and the formation of Russell bodies.…”

Rare Gastric Lesions Associated with Helicobacter pylori Infection: A Histopathological Review

“…Previous reports describe Mott cell proliferation (features of RBG) in association with gastric carcinoma, including two cases of Epstein-Barr virus–positive lymphoepithelioma-like carcinoma [55], and one case of signet ring cell carcinoma [57]. In these cases, Mott cell proliferation was likely a reactive paraneoplastic event, given that the carcinoma and Mott cells did not mix and that the Mott cells were polyclonal.…”

“…Although its pathogenesis has not been fully elucidated, there is evidence to support a strong association between H. pylori infection and RBG development. For example, H. pylori is detected in approximately two-thirds of patients with RBG [8,9,19-21,48,50,52,53,55,57,60,61]. Few other infections that have been reported with RBG include human immunodeficiency virus (three patients) [51,53,59], hepatitis C virus (one patient) [58], and candida esophagitis (one case) [49].…”

“…In addition, in cases with abundant Mott cells and a few neoplastic cells, neoplastic cells may not be easily detected. Thus, immunostaining for cytokeratin should be conducted to exclude associated carcinoma [55,57]. Furthermore, if light chain monoclonality is detected, pathologists should consider associated MALT lymphoma and perform ancillary immunostaining (e.g., for CD20 and cytokeratin) to identify centrocytelike cells and lymphoepithelial lesions (Fig.…”

Pathology of non-Helicobacter pylori gastritis: extending the histopathologic horizons

“…14) The pattern of gastritis related to the accumulation of immunoglobulin has been commonly associated with H. pylori infection [86][87][88]. However, prominent Mott cell proliferation has also been reported in an EBV-associated gastric adenocarcinoma [89]. Specific forms of gastritis…”