Rare Gastric Lesions Associated with Helicobacter pylori Infection: A Histopathological Review

Abstract

Helicobacter pylori infection is associated with chronic gastritis, peptic ulcer disease, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. However, some rare gastric lesions exhibiting distinctive histological features may also be associated with H. pylori infection, including lymphocytic gastritis, granulomatous gastritis, Russell body gastritis, or crystal-storing histiocytosis. Although diverse factors can contribute to their development, there is convincing evidence that H. pylori infection may play a pathogenic role. These findings are mainly based on studies in patients with these lesions who exhibited clinical and histological improvements after H. pylori eradication therapy. Thus, H. pylori eradication therapy might be indicated in patients with no other underlying disease, particularly in countries with a high prevalence of H. pylori infection. This review describes the characteristic histological features of these rare lesions and evaluates the evidence regarding a causative role for H. pylori infection in their pathogenesis.

Nonimmunoglobulin Crystal-Storing Histiocytosis (CSH): Case Report and Literature Review

“…Strongyloides causes direct eosinophilic infiltrate in the colonic mucosa [ 14 ], and as a result, CLC deposits could be expected even in the absence of colorectal symptoms, as was seen in our patient. H. pylori have been described as a cause of CSH in the stomach [ 15 ]. Therefore, it could potentially be a differential etiology for our patients with colonic CSH.…”

“…CSH has been reported as a first manifestation or a subclinical stage of underlying neoplasms such as thymic lymphoma, multiple myeloma, or lymphoreticular malignancy [ 1 , 15 ]. As such, an initial negative evaluation for an LP-PCD does not obviate the need for a close follow-up in patients diagnosed with either immunoglobulin or nonimmunoglobulin CSH.…”

Lymphocytic gastritis

“…The others might include nodularity or mucosal elevations, polyps, aphthous erosions, ulcers or ulcer scars. Thickened or giant gastric folds like that in hypertrophic gastritis, or above mentioned -nodular targetoid erosions (varioliform) are rarely observed [5,6,4]. Moreover, local spots ( Fig.…”

“…Patients with LG do not present specific symptoms. The most common ones are dyspepsia, upper abdominal pain, heartburn, vomiting or weight loss [3,4]. The symptoms may also be caused by primary diseases that are believed to be linked with LG, like gastric lymphomas, HIV infection, Crohn's disease, Menetier's disease, inflammatory polyp, or esophageal carcinoma.…”

Sistem Pakar Diagnosis Penyakit Gastritis Menggunakan Metode Certainty Factor Berbasis Android

“…Gejala yang muncul adalah adanya rasa nyeri pada daerah epigastrium. Sehingga para dokter memerlukan adanya diagnosis lebih lanjut, dimana untuk memastikan gastritis memerlukan pemeriksaan penunjang seperti endoskopi [5] [6].…”